NP_002300.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,008 Da
NCBI Official Full Name
leukemia inhibitory factor isoform 1
NCBI Official Synonym Full Names
leukemia inhibitory factor
NCBI Protein Information
leukemia inhibitory factor; D factor; human interleukin in DA cells; melanoma-derived LPL inhibitor; differentiation-inducing factor; hepatocyte-stimulating factor III; cholinergic differentiation factor; differentiation-stimulating factor; differentiation inhibitory activity
UniProt Protein Name
Leukemia inhibitory factor
UniProt Synonym Protein Names
Differentiation-stimulating factor; D factor; Melanoma-derived LPL inhibitor
UniProt Synonym Gene Names
UniProt Entry Name
LIF_HUMAN
NCBI Summary for LIF
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
UniProt Comments for LIF
LIF: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes. Belongs to the LIF/OSM family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component: extracellular space; cytoplasm
Molecular Function: growth factor activity; leukemia inhibitory factor receptor binding; cytokine activity; receptor binding
Biological Process: transcription from RNA polymerase II promoter; multicellular organismal development; negative regulation of hormone secretion; leukemia inhibitory factor signaling pathway; tyrosine phosphorylation of Stat3 protein; decidualization; positive regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of cell proliferation; positive regulation of MAPKKK cascade; negative regulation of meiosis; positive regulation of cell proliferation; positive regulation of macrophage differentiation; muscle morphogenesis; positive regulation of peptidyl-serine phosphorylation of STAT protein; positive regulation of astrocyte differentiation; stem cell maintenance; positive regulation of peptidyl-serine phosphorylation; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of peptidyl-tyrosine phosphorylation; neuron development; blood vessel remodeling; immune response; positive regulation of transcription from RNA polymerase II promoter; alveolus development; embryo implantation
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Products associated with LIF elisa kit
Pathways associated with LIF elisa kit
Diseases associated with LIF elisa kit
Organs/Tissues associated with LIF elisa kit
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