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LIPA elisa kit :: Goose Lipase A, Lysosomal Acid ELISA Kit

Scan QR to view Datasheet Catalog #    MBS090168 LIPA elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lipase A, Lysosomal Acid, ELISA Kit

 Also Known As   

Goose Lipase A, Lysosomal Acid ELISA Kit

 Product Gene Name   

LIPA elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 OMIM    278000
 3D Structure    ModBase 3D Structure for P38571
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 Species Reactivity    Goose
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of LIPA elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for LIPA purchase    MBS090168 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Lipase A, Lysosomal Acid, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing LIPA. The ELISA analytical biochemical technique of the MBS090168 kit is based on LIPA antibody-LIPA antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LIPA antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LIPA. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for LIPA. It may not necessarily be applicable to this product.
 NCBI GI #    68067636
 NCBI GeneID    3988
 NCBI Accession #    P38571.2 [Other Products]
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 UniProt Primary Accession #    P38571 [Other Products]
 UniProt Secondary Accession #    Q16529; Q53H21; Q5T074; Q5T771; Q96EJ0; B2RBH5; D3DR29 [Other Products]
 UniProt Related Accession #    P38571 [Other Products]
 Molecular Weight    45,419 Da
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 NCBI Official Full Name    Lysosomal acid lipase/cholesteryl ester hydrolase
 NCBI Official Synonym Full Names    lipase A, lysosomal acid, cholesterol esterase
 NCBI Official Symbol    LIPA [Similar Products]
 NCBI Official Synonym Symbols   
LAL; CESD
[Similar Products]
 NCBI Protein Information    lysosomal acid lipase/cholesteryl ester hydrolase; sterol esterase; cholesteryl esterase; cholesterol ester hydrolase; acid cholesteryl ester hydrolase
 UniProt Protein Name    Lysosomal acid lipase/cholesteryl ester hydrolase
 UniProt Synonym Protein Names   
Cholesteryl esterase; Lipase A; Sterol esterase
 Protein Family    Lipoprotein
 UniProt Gene Name    LIPA [Similar Products]
 UniProt Synonym Gene Names    Acid cholesteryl ester hydrolase; LAL [Similar Products]
 UniProt Entry Name    LICH_HUMAN
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 NCBI Summary for LIPA    This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]
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 UniProt Comments for LIPA    LIPA: Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation. Defects in LIPA are the cause of Wolman disease (WOD). WOD is a severe manifestation of LIPA deficiency, leading to the accumulation of cholesteryl esters and triglycerides in most tissues of the body. WOD occurs in infancy and is nearly always fatal before the age of 1 year. Defects in LIPA are the cause of cholesteryl ester storage disease (CESD). CESD is a mild manifestation of LIPA deficiency, leading to the accumulation of cholesteryl esters and triglycerides in most tissues of the body. It is characterized by late-onset. Belongs to the AB hydrolase superfamily. Lipase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.1.13; Lipid Metabolism - steroid biosynthesis; Hydrolase

Chromosomal Location of Human Ortholog: 10q23.2-q23.3

Cellular Component: lysosome

Molecular Function: sterol esterase activity; lipase activity

Biological Process: cell proliferation; homeostasis of number of cells within a tissue; tissue remodeling; cell morphogenesis; cytokine production; inflammatory response; lipid catabolic process; lung development

Disease: Lysosomal Acid Lipase Deficiency
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 Research Articles on LIPA    1. To our knowledge, this is the first pediatric case of genetically and biopsy confirmed CESD without hepatomegaly, suggesting that this diagnosis can be easily missed.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LIPA elisa kitPathways associated with LIPA elisa kit
 Reference Product  PubMed Publications
 CH25H elisa kit  >3 publications with LIPA and CH25H
 SOAT1 elisa kit  >2 publications with LIPA and SOAT1
 CYP7A1 elisa kit  >1 publications with LIPA and CYP7A1
 Products by Pathway  Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Phase I, Non P450 Pathway antibodies  Phase I, Non P450 Pathway Diagram
 Steroid Biosynthesis Pathway antibodies  Steroid Biosynthesis Pathway Diagram
 Steroid Biosynthesis Pathway antibodies  Steroid Biosynthesis Pathway Diagram
Diseases associated with LIPA elisa kitOrgans/Tissues associated with LIPA elisa kit
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >258 publications with LIPA and Liver Diseases
 Neoplasms Antibodies  >183 publications with LIPA and Neoplasms
 Cardiovascular Diseases Antibodies  >40 publications with LIPA and Cardiovascular Diseases
 Liver Cirrhosis Antibodies  >32 publications with LIPA and Liver Cirrhosis
 Fibrosis Antibodies  >31 publications with LIPA and Fibrosis
 Lysosomal acid lipase deficiency Antibodies  >29 publications with LIPA and Lysosomal acid lipase deficiency
 Carcinoma, Hepatocellular Antibodies  >25 publications with LIPA and Carcinoma, Hepatocellular
 Inflammation Antibodies  >24 publications with LIPA and Inflammation
 Nervous System Diseases Antibodies  >24 publications with LIPA and Nervous System Diseases
 Breast Neoplasms Antibodies  >21 publications with LIPA and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >227 publications with LIPA and Blood
 Liver Antibodies  >118 publications with LIPA and Liver
 Cervix Antibodies  >51 publications with LIPA and Cervix
 Uterus Antibodies  >39 publications with LIPA and Uterus
 Vascular Antibodies  >35 publications with LIPA and Vascular
 Skin Antibodies  >30 publications with LIPA and Skin
 Muscle Antibodies  >29 publications with LIPA and Muscle
 Brain Antibodies  >28 publications with LIPA and Brain
 Lung Antibodies  >20 publications with LIPA and Lung
 Kidney Antibodies  >17 publications with LIPA and Kidney
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