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SMAD7 elisa kit :: Goose Mothers Against Decapentaplegic Homolog 7 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS027559 SMAD7 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Mothers Against Decapentaplegic Homolog 7 (SMAD7), ELISA Kit

 Also Known As   

Goose Mothers Against Decapentaplegic Homolog 7 ELISA Kit

 Product Gene Name   

SMAD7 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 18; NC_000018.9 (46446223..46477081, complement). Location: 18q21.1
 OMIM    602932
 3D Structure    ModBase 3D Structure for O15105
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 Species Reactivity    Goose
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SMAD7 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SMAD7 purchase    MBS027559 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Mothers Against Decapentaplegic Homolog 7 (SMAD7) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SMAD7. The ELISA analytical biochemical technique of the MBS027559 kit is based on SMAD7 antibody-SMAD7 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SMAD7 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SMAD7. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for SMAD7. It may not necessarily be applicable to this product.
 NCBI GI #    18418630
 NCBI GeneID    4092
 NCBI Accession #    AAL68977.1 [Other Products]
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 UniProt Primary Accession #    O15105 [Other Products]
 UniProt Secondary Accession #    O14740; Q6DK23; B7Z773; K7EQ10 [Other Products]
 UniProt Related Accession #    O15105 [Other Products]
 Molecular Weight    46,426 Da
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 NCBI Official Full Name    Smad7
 NCBI Official Synonym Full Names    SMAD family member 7
 NCBI Official Symbol    SMAD7 [Similar Products]
 NCBI Official Synonym Symbols   
CRCS3; MADH7; MADH8
[Similar Products]
 NCBI Protein Information    mothers against decapentaplegic homolog 7; hSMAD7; MAD homolog 8; mothers against DPP homolog 8; SMAD, mothers against DPP homolog 7; Mothers against decapentaplegic, drosophila, homolog of, 7; MAD (mothers against decapentaplegic, Drosophila) homolog 7
 UniProt Protein Name    Mothers against decapentaplegic homolog 7
 UniProt Synonym Protein Names   
Mothers against decapentaplegic homolog 8; MAD homolog 8; Mothers against DPP homolog 8; SMAD family member 7
 Protein Family    Mothers against decapentaplegic
 UniProt Gene Name    SMAD7 [Similar Products]
 UniProt Synonym Gene Names    MADH7; MADH8; MAD homolog 7; Mothers against DPP homolog 7; MAD homolog 8; Mothers against DPP homolog 8; SMAD 7; Smad7; hSMAD7 [Similar Products]
 UniProt Entry Name    SMAD7_HUMAN
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 NCBI Summary for SMAD7    The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
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 UniProt Comments for SMAD7    SMAD7: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Genetic variations in SMAD7 influence susceptibility to colorectal cancer type 3 (CRCS3). Colorectal cancer consists of tumors or cancer of either the colon or rectum or both. Cancers of the large intestine are the second most common form of cancer found in males and females. Symptoms include rectal bleeding, occult blood in stools, bowel obstruction and weight loss. Treatment is based largely on the extent of cancer penetration into the intestinal wall. Surgical cures are possible if the malignancy is confined to the intestine. Risk can be reduced when following a diet which is low in fat and high in fiber. Belongs to the dwarfin/SMAD family.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 18q21.1

Cellular Component: nucleoplasm; transcription factor complex; cell-cell adherens junction; protein complex; cytoplasm; plasma membrane; catenin complex; nucleus; cytosol

Molecular Function: collagen binding; protein binding; metal ion binding; ubiquitin protein ligase binding; beta-catenin binding; activin binding; transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; protein stabilization; transcription, DNA-dependent; negative regulation of transcription factor activity; negative regulation of peptidyl-serine phosphorylation; negative regulation of transcription from RNA polymerase II promoter; regulation of activin receptor signaling pathway; negative regulation of BMP signaling pathway; BMP signaling pathway; regulation of transforming growth factor beta receptor signaling pathway; positive regulation of protein ubiquitination; ureteric bud development; transforming growth factor beta receptor signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of cell-cell adhesion; negative regulation of ubiquitin-protein ligase activity; artery morphogenesis; ventricular cardiac muscle morphogenesis; negative regulation of protein ubiquitination; gene expression; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of cell migration

Disease: Colorectal Cancer, Susceptibility To, 3
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 Research Articles on SMAD7    1. MiR-25 may function as a tumor suppressor by targeting Smad7 in colon cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SMAD7 elisa kitPathways associated with SMAD7 elisa kit
 Reference Product  PubMed Publications
 TGFB1 elisa kit  >464 publications with SMAD7 and TGFB1
 SMAD4 elisa kit  >260 publications with SMAD7 and SMAD4
 SMURF2 elisa kit  >53 publications with SMAD7 and SMURF2
 SMURF1 elisa kit  >28 publications with SMAD7 and SMURF1
 TGFBR1 elisa kit  >14 publications with SMAD7 and TGFBR1
 BMPR1A elisa kit  >12 publications with SMAD7 and BMPR1A
 WWP1 elisa kit  >3 publications with SMAD7 and WWP1
 HDAC1 elisa kit  >2 publications with SMAD7 and HDAC1
 UBC elisa kit  >1 publications with SMAD7 and UBC
 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 Downregulation Of TGF-beta Receptor Signaling Pathway antibodies  Downregulation Of TGF-beta Receptor Signaling Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 IFN-gamma Pathway antibodies  IFN-gamma Pathway Diagram
Diseases associated with SMAD7 elisa kitOrgans/Tissues associated with SMAD7 elisa kit
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >299 publications with SMAD7 and Fibrosis
 Neoplasms Antibodies  >213 publications with SMAD7 and Neoplasms
 Inflammation Antibodies  >121 publications with SMAD7 and Inflammation
 Disease Models, Animal Antibodies  >93 publications with SMAD7 and Disease Models, Animal
 Kidney Diseases Antibodies  >84 publications with SMAD7 and Kidney Diseases
 Liver Diseases Antibodies  >78 publications with SMAD7 and Liver Diseases
 Necrosis Antibodies  >52 publications with SMAD7 and Necrosis
 Cardiovascular Diseases Antibodies  >49 publications with SMAD7 and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >44 publications with SMAD7 and Adenocarcinoma
 Liver Cirrhosis Antibodies  >44 publications with SMAD7 and Liver Cirrhosis
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >191 publications with SMAD7 and Bone
 Muscle Antibodies  >175 publications with SMAD7 and Muscle
 Kidney Antibodies  >156 publications with SMAD7 and Kidney
 Blood Antibodies  >152 publications with SMAD7 and Blood
 Connective Tissue Antibodies  >95 publications with SMAD7 and Connective Tissue
 Lung Antibodies  >94 publications with SMAD7 and Lung
 Vascular Antibodies  >92 publications with SMAD7 and Vascular
 Embryonic Tissue Antibodies  >60 publications with SMAD7 and Embryonic Tissue
 Heart Antibodies  >48 publications with SMAD7 and Heart
 Eye Antibodies  >36 publications with SMAD7 and Eye
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