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PPARgamma elisa kit :: Goose Peroxisome Proliferators Activated Receptor gamma ELISA Kit

Scan QR to view Datasheet Catalog #    MBS009228 PPARgamma elisa kit
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Peroxisome Proliferators Activated Receptor gamma (PPARgamma), ELISA Kit

 Also Known As   

Goose Peroxisome Proliferators Activated Receptor gamma ELISA Kit

 Product Gene Name   

PPARgamma elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 3; NC_000003.11 (12329349..12475855). Location: 3p25
 OMIM    137800
 3D Structure    ModBase 3D Structure for P37231
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 Species Reactivity    Goose
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PPARgamma elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PPARgamma purchase    MBS009228 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Peroxisome Proliferators Activated Receptor gamma (PPARgamma) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PPARgamma. The ELISA analytical biochemical technique of the MBS009228 kit is based on PPARgamma antibody-PPARgamma antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PPARgamma antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PPARgamma. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for PPARgamma. It may not necessarily be applicable to this product.
 NCBI GI #    116284373
 NCBI GeneID    5468
 NCBI Accession #    NP_619725.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_138711.3 [Other Products]
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 UniProt Primary Accession #    P37231 [Other Products]
 UniProt Secondary Accession #    O00684; O00710; O14515; Q0QJH8; Q15178; Q15179; Q15180; Q15832; Q86U60; A8K3G6; B5BUA1 [Other Products]
 UniProt Related Accession #    P37231 [Other Products]
 Molecular Weight    57,620 Da
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 NCBI Official Full Name    peroxisome proliferator-activated receptor gamma isoform 1
 NCBI Official Synonym Full Names    peroxisome proliferator-activated receptor gamma
 NCBI Official Symbol    PPARG [Similar Products]
 NCBI Official Synonym Symbols   
GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma
[Similar Products]
 NCBI Protein Information    peroxisome proliferator-activated receptor gamma; PPAR gamma; PPAR-gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated receptor gamma 1; peroxisome proliferator-activated nuclear receptor gamma variant 1
 UniProt Protein Name    Peroxisome proliferator-activated receptor gamma
 UniProt Synonym Protein Names   
Nuclear receptor subfamily 1 group C member 3
 UniProt Gene Name    PPARG [Similar Products]
 UniProt Synonym Gene Names    NR1C3; PPAR-gamma [Similar Products]
 UniProt Entry Name    PPARG_HUMAN
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 NCBI Summary for PPARgamma    This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PPARgamma    PPAR-gamma: a transcription factor, member of the nuclear hormone receptor superfamily. Receptor for hypolipidemic drugs and fatty acids. Preferentially expressed in adipocytes as well as in vascular smooth muscle cells and macrophage. Regulator of adipogenesis and lipid metabolism, modulates insulin sensitivity, cell proliferation and inflammation. Phosphorylated and inhibited by MAP kinase. Heterodimerizes with the retinoid X receptor. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Two splice-variant isoforms have been described.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 3p25

Cellular Component: nucleoplasm; perinuclear region of cytoplasm; nucleus; cytosol

Molecular Function: ligand-dependent nuclear receptor activity; transcription activator binding; zinc ion binding; drug binding; alpha-actinin binding; protein phosphatase binding; arachidonic acid binding; retinoid X receptor binding; protein binding; enzyme binding; ligand-dependent nuclear receptor transcription coactivator activity; DNA binding; prostaglandin receptor activity; sequence-specific DNA binding; steroid hormone receptor activity; estrogen receptor binding; chromatin binding; transcription factor activity

Biological Process: positive regulation of transcription, DNA-dependent; negative regulation of collagen biosynthetic process; heart development; cell maturation; rhythmic process; lipid homeostasis; glucose homeostasis; response to lipid; response to caffeine; response to vitamin A; positive regulation of oligodendrocyte differentiation; placenta development; long-chain fatty acid transport; organ regeneration; cell fate commitment; monocyte differentiation; negative regulation of acute inflammatory response; regulation of circadian rhythm; response to starvation; negative regulation of telomerase activity; cellular response to insulin stimulus; response to estrogen stimulus; lipoprotein transport; response to mechanical stimulus; brown fat cell differentiation; positive regulation of fat cell differentiation; steroid hormone mediated signaling; fatty acid oxidation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; positive regulation of phagocytosis, engulfment; negative regulation of smooth muscle cell proliferation; low-density lipoprotein receptor biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; signal transduction; epithelial cell differentiation; regulation of blood pressure; response to nutrient; caspase activation; transcription initiation from RNA polymerase II promoter; response to retinoic acid; G-protein coupled receptor protein signaling pathway; response to low density lipoprotein stimulus; white fat cell differentiation; positive regulation of fatty acid oxidation; innate immune response; gene expression; lipid metabolic process; negative regulation of cell growth; response to cold

Disease: Obesity; Lipodystrophy, Familial Partial, Type 3; Carotid Intimal Medial Thickness 1; Diabetes Mellitus, Noninsulin-dependent
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 Research Articles on PPARgamma    1. The induction of three enzymes whose activity can potentially generate endogenous PPARgamma ligands in an IL-4 dependent manner.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PPARgamma elisa kitDiseases associated with PPARgamma elisa kit
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Energy Metabolism Pathway antibodies  Energy Metabolism Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Metabolic Diseases Antibodies  >2371 publications with PPARgamma and Metabolic Diseases
 Inflammation Antibodies  >1588 publications with PPARgamma and Inflammation
 Obesity Antibodies  >1549 publications with PPARgamma and Obesity
 Diabetes Mellitus Antibodies  >1528 publications with PPARgamma and Diabetes Mellitus
 Insulin Resistance Antibodies  >1518 publications with PPARgamma and Insulin Resistance
 Diabetes Mellitus, Type 2 Antibodies  >1044 publications with PPARgamma and Diabetes Mellitus, Type 2
 Necrosis Antibodies  >819 publications with PPARgamma and Necrosis
 Fatty Liver Antibodies  >656 publications with PPARgamma and Fatty Liver
 Atherosclerosis Antibodies  >652 publications with PPARgamma and Atherosclerosis
 Hypertension Antibodies  >501 publications with PPARgamma and Hypertension
Organs/Tissues associated with PPARgamma elisa kit
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1554 publications with PPARgamma and Liver
 Adipose Tissue Antibodies  >1548 publications with PPARgamma and Adipose Tissue
 Connective Tissue Antibodies  >1112 publications with PPARgamma and Connective Tissue
 Vascular Antibodies  >1077 publications with PPARgamma and Vascular
 Heart Antibodies  >650 publications with PPARgamma and Heart
 Bone Antibodies  >538 publications with PPARgamma and Bone
 Brain Antibodies  >527 publications with PPARgamma and Brain
 Kidney Antibodies  >487 publications with PPARgamma and Kidney
 Lung Antibodies  >395 publications with PPARgamma and Lung
 Intestine Antibodies  >224 publications with PPARgamma and Intestine
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