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PIR elisa kit :: Goose Pirin ELISA Kit

Scan QR to view Datasheet Catalog #    MBS038349 PIR elisa kit
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Pirin, ELISA Kit

 Also Known As   

Goose Pirin ELISA Kit

 Product Gene Name   

PIR elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: X; NC_000023.10 (15402921..15511711, complement). Location: Xp22.2
 OMIM    603329
 3D Structure    ModBase 3D Structure for O00625
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 Species Reactivity    Goose
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PIR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PIR purchase    MBS038349 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Pirin, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PIR. The ELISA analytical biochemical technique of the MBS038349 kit is based on PIR antibody-PIR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PIR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PIR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for PIR. It may not necessarily be applicable to this product.
 NCBI GI #    66363697
 NCBI GeneID    8544
 NCBI Accession #    NP_001018119.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001018109.2 [Other Products]
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 UniProt Primary Accession #    O00625 [Other Products]
 UniProt Secondary Accession #    Q5U0G0; Q6FHD2 [Other Products]
 UniProt Related Accession #    O00625 [Other Products]
 Molecular Weight    32,113 Da
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 NCBI Official Full Name    pirin
 NCBI Official Synonym Full Names    pirin (iron-binding nuclear protein)
 NCBI Official Symbol    PIR [Similar Products]
 NCBI Protein Information    pirin; probable quercetinase; probable quercetin 2,3-dioxygenase PIR
 UniProt Protein Name    Pirin
 UniProt Synonym Protein Names   
Probable quercetin 2,3-dioxygenase PIR
 Protein Family    Pirin
 UniProt Gene Name    PIR [Similar Products]
 UniProt Synonym Gene Names    Probable quercetinase [Similar Products]
 UniProt Entry Name    PIR_HUMAN
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 NCBI Summary for PIR    This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PIR    PIR: Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro). May interact with NF1/CTF1. Interacts with BCL3. Identified in a complex comprised of PIR, BLC3, NFKB1 and target DNA. Up-regulated in CD34(+) cells upon myelomonocytic differentiation. Down-regulated in many acute myeloid leukemias. Up-regulated in primary bronchial epithelial cells exposed to cigarette smoke extract. Highly expressed in a subset of melanomas. Detected at very low levels in most tissues. Expressed in all tissues, with highest level of expression in heart and liver. Inhibited by kojic acid, sodium diethyldithiocarbamate and 1,10-phenanthroline monohydrochloride. Belongs to the pirin family.

Protein type: EC

Chromosomal Location of Human Ortholog: Xp22.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; metal ion binding; transcription cofactor activity; quercetin 2,3-dioxygenase activity

Biological Process: transcription from RNA polymerase II promoter; monocyte differentiation; regulation of transcription, DNA-dependent
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 Research Articles on PIR    1. pirin may have a relevant role in melanoma progression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PIR elisa kitDiseases associated with PIR elisa kit
 Reference Product  PubMed Publications
 GALE elisa kit  >3 publications with PIR and GALE
 CTF1 elisa kit  >2 publications with PIR and CTF1
 SOD2 elisa kit  >1 publications with PIR and SOD2
 BCL3 elisa kit  >1 publications with PIR and BCL3
 NFIX elisa kit  >1 publications with PIR and NFIX
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >67 publications with PIR and Neoplasms
 Disease Models, Animal Antibodies  >31 publications with PIR and Disease Models, Animal
 Drug Toxicity Antibodies  >25 publications with PIR and Drug Toxicity
 Inflammation Antibodies  >19 publications with PIR and Inflammation
 Carcinoma Antibodies  >19 publications with PIR and Carcinoma
 Adenocarcinoma Antibodies  >16 publications with PIR and Adenocarcinoma
 Necrosis Antibodies  >14 publications with PIR and Necrosis
 Liver Diseases Antibodies  >11 publications with PIR and Liver Diseases
 Liver Neoplasms Antibodies  >10 publications with PIR and Liver Neoplasms
 Kidney Diseases Antibodies  >10 publications with PIR and Kidney Diseases
Organs/Tissues associated with PIR elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >123 publications with PIR and Brain
 Bone Marrow Antibodies  >25 publications with PIR and Bone Marrow
 Skin Antibodies  >22 publications with PIR and Skin
 Mixed Antibodies  >19 publications with PIR and Mixed
 Placenta Antibodies  >11 publications with PIR and Placenta
 Uterus Antibodies  >3 publications with PIR and Uterus
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