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TAB elisa kit :: Goose Thyroid Antibody ELISA Kit

Scan QR to view Datasheet Catalog #    MBS032196 TAB elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thyroid Antibody (TAB), ELISA Kit

 Also Known As   

Goose Thyroid Antibody ELISA Kit

 Product Gene Name   

TAB elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    275200
 3D Structure    ModBase 3D Structure for P16473
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 Species Reactivity    Goose
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TAB elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TAB purchase    MBS032196 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Thyroid Antibody (TAB) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TAB. The ELISA analytical biochemical technique of the MBS032196 kit is based on TAB antibody-TAB antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TAB antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TAB. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for TAB. It may not necessarily be applicable to this product.
 NCBI GI #    62298994
 NCBI GeneID    7253
 NCBI Accession #    P16473.2 [Other Products]
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 UniProt Primary Accession #    P16473 [Other Products]
 UniProt Secondary Accession #    Q16503; Q8TB90; Q96GT6; Q9P1V4; Q9ULA3; Q9UPH3; A0PJU7; F5GYU5; G3V2A9 [Other Products]
 UniProt Related Accession #    P16473 [Other Products]
 Molecular Weight    86,830 Da
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 NCBI Official Full Name    Thyrotropin receptor
 NCBI Official Synonym Full Names    thyroid stimulating hormone receptor
 NCBI Official Symbol    TSHR [Similar Products]
 NCBI Official Synonym Symbols   
LGR3; CHNG1; hTSHR-I
[Similar Products]
 NCBI Protein Information    thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; seven transmembrane helix receptor; thyroid stimulating hormone receptor, isoform 2
 UniProt Protein Name    Thyrotropin receptor
 UniProt Synonym Protein Names   
Thyroid-stimulating hormone receptor
 UniProt Gene Name    TSHR [Similar Products]
 UniProt Synonym Gene Names    LGR3; TSH-R [Similar Products]
 UniProt Entry Name    TSHR_HUMAN
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 NCBI Summary for TAB    The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
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 UniProt Comments for TAB    TSHR: Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5). Defects in TSHR are found in patients affected by hyperthyroidism with different etiologies. Somatic, constitutively activating TSHR mutations and/or constitutively activating G(s)alpha mutations have been identified in toxic thyroid nodules (TTNs) that are the predominant cause of hyperthyroidism in iodine deficient areas. These mutations lead to TSH independent activation of the cAMP cascade resulting in thyroid growth and hormone production. TSHR mutations are found in autonomously functioning thyroid nodules (AFTN), toxic multinodular goiter (TMNG) and hyperfunctioning thyroid adenomas (HTA). TMNG encompasses a spectrum of different clinical entities, ranging from a single hyperfunctioning nodule within an enlarged thyroid, to multiple hyperfunctioning areas scattered throughout the gland. HTA are discrete encapsulated neoplasms characterized by TSH- independent autonomous growth, hypersecretion of thyroid hormones, and TSH suppression. Defects in TSHR are also a cause of thyroid neoplasms (papillary and follicular cancers). Autoantibodies against TSHR are directly responsible for the pathogenesis and hyperthyroidism of Graves disease. Antibody interaction with TSHR results in an uncontrolled receptor stimulation. Defects in TSHR are the cause of congenital hypothyroidism non-goitrous type 1 (CHNG1); also known as congenital hypothyroidism due to TSH resistance. CHNG1 is a non-autoimmune condition characterized by resistance to thyroid- stimulating hormone (TSH) leading to increased levels of plasma TSH and low levels of thyroid hormone. CHNG1 presents variable severity depending on the completeness of the defect. Most patients are euthyroid and asymptomatic, with a normal sized thyroid gland. Only a subset of patients develop hypothyroidism and present a hypoplastic thyroid gland. Defects in TSHR are the cause of familial gestational hyperthyroidism (HTFG). HTFG is a condition characterized by abnormally high levels of serum thyroid hormones occurring during early pregnancy. Defects in TSHR are the cause of hyperthyroidism non- autoimmune (HTNA). It is a condition characterized by abnormally high levels of serum thyroid hormones, thyroid hyperplasia, goiter and lack of anti-thyroid antibodies. Typical features of Graves disease such as exophthalmia, myxedema, antibodies anti-TSH receptor and lymphocytic infiltration of the thyroid gland are absent. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 14q31

Cellular Component: integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: protein binding; thyroid-stimulating hormone receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; cell-cell signaling; positive regulation of cell proliferation

Disease: Hyperthyroidism, Nonautoimmune; Hypothyroidism, Congenital, Nongoitrous, 1; Hyperthyroidism, Familial Gestational
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 Research Articles on TAB    1. the mechanism through which the W520X mutation exerts its effect is more likely haploinsufficiency rather than a dominant-negative effect which could explain the phenotype of the patient, who has a hormonal pattern in the range of mild subclinical hypothyroidism without overt disease phenotype
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TAB elisa kitDiseases associated with TAB elisa kit
 Reference Product  PubMed Publications
 GNAS elisa kit  >16 publications with TAB and GNAS
 TSHB elisa kit  >7 publications with TAB and TSHB
 LHCGR elisa kit  >5 publications with TAB and LHCGR
 PTH elisa kit  >4 publications with TAB and PTH
 STAT3 elisa kit  >4 publications with TAB and STAT3
 CALCA elisa kit  >2 publications with TAB and CALCA
 POMC elisa kit  >1 publications with TAB and POMC
 Disease Name  Pubmed Publications
 Hyperthyroidism Antibodies  >493 publications with TAB and Hyperthyroidism
 Graves Disease Antibodies  >453 publications with TAB and Graves Disease
 Neoplasms Antibodies  >169 publications with TAB and Neoplasms
 Thyroid Neoplasms Antibodies  >161 publications with TAB and Thyroid Neoplasms
 Thyroiditis, Autoimmune Antibodies  >107 publications with TAB and Thyroiditis, Autoimmune
 Carcinoma Antibodies  >95 publications with TAB and Carcinoma
 Disease Models, Animal Antibodies  >81 publications with TAB and Disease Models, Animal
 Congenital Hypothyroidism Antibodies  >73 publications with TAB and Congenital Hypothyroidism
 Adenoma Antibodies  >49 publications with TAB and Adenoma
 Thyrotoxicosis Antibodies  >40 publications with TAB and Thyrotoxicosis
Organs/Tissues associated with TAB elisa kit
 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >1030 publications with TAB and Thyroid
 Blood Antibodies  >334 publications with TAB and Blood
 Ovary Antibodies  >78 publications with TAB and Ovary
 Connective Tissue Antibodies  >57 publications with TAB and Connective Tissue
 Muscle Antibodies  >40 publications with TAB and Muscle
 Brain Antibodies  >30 publications with TAB and Brain
 Thymus Antibodies  >12 publications with TAB and Thymus
 Lung Antibodies  >10 publications with TAB and Lung
 Embryonic Tissue Antibodies  >6 publications with TAB and Embryonic Tissue
 Placenta Antibodies  >2 publications with TAB and Placenta
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