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TPA elisa kit :: Goose Tissue Type Plasminogen Activator ELISA Kit

Scan QR to view Datasheet Catalog #    MBS022331 TPA elisa kit
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tissue Type Plasminogen Activator (TPA), ELISA Kit

 Also Known As   

Goose Tissue Type Plasminogen Activator ELISA Kit

 Product Gene Name   

TPA elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 8; NC_000008.10 (42032236..42065194, complement). Location: 8p12
 OMIM    173370
 3D Structure    ModBase 3D Structure for P00750
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 Species Reactivity    Goose
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TPA elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TPA purchase    MBS022331 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Tissue Type Plasminogen Activator (TPA) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TPA. The ELISA analytical biochemical technique of the MBS022331 kit is based on TPA antibody-TPA antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TPA antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TPA. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for TPA. It may not necessarily be applicable to this product.
 NCBI GI #    190032
 NCBI GeneID    5327
 NCBI Accession #    AAA60111.1 [Other Products]
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 UniProt Primary Accession #    P00750 [Other Products]
 UniProt Secondary Accession #    Q15103; Q503B0; Q6PJA5; Q7Z7N2; Q86YK8; Q9BU99; Q9BZW1; A8K022; B2R8E8 [Other Products]
 UniProt Related Accession #    P00750 [Other Products]
 Molecular Weight    62,917 Da
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 NCBI Official Full Name    tissue-type plasminogen activator
 NCBI Official Synonym Full Names    plasminogen activator, tissue
 NCBI Official Symbol    PLAT [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    tissue-type plasminogen activator; alteplase; reteplase; t-plasminogen activator; plasminogen activator, tissue type; tissue plasminogen activator (t-PA)
 UniProt Protein Name    Tissue-type plasminogen activator
 Protein Family    Taurine--pyruvate aminotransferase
 UniProt Gene Name    PLAT [Similar Products]
 UniProt Synonym Gene Names    t-PA; t-plasminogen activator; tPA [Similar Products]
 UniProt Entry Name    TPA_HUMAN
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 NCBI Summary for TPA    This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TPA    PLAT: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration. Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism. Belongs to the peptidase S1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Protease; Vesicle; EC; Secreted; Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 8p12

Cellular Component: extracellular matrix; extracellular space; cell surface; apical part of cell; cytoplasm; extracellular region; synapse; secretory granule

Molecular Function: protein binding; serine-type endopeptidase activity

Biological Process: negative regulation of proteolysis; synaptic transmission, glutamatergic; response to peptide hormone stimulus; response to cAMP; smooth muscle cell migration; protein modification process; regulation of synaptic plasticity; platelet-derived growth factor receptor signaling pathway; proteolysis; fibrinolysis; response to hypoxia; blood coagulation; transmembrane transport; plasminogen activation

Disease: Thrombophilia, Familial, Due To Decreased Release Of Tissue Plasminogen Activator
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 Research Articles on TPA    1. This meta-analysis suggested that the -7351C/T polymorphism in TPA gene would be a risk factor for ischemic stroke.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with TPA elisa kitDiseases associated with TPA elisa kit
 Products by Pathway  Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Dissolution Of Fibrin Clot Pathway antibodies  Dissolution Of Fibrin Clot Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >27 publications with TPA and Inflammation
 Arterial Occlusive Diseases Antibodies  >22 publications with TPA and Arterial Occlusive Diseases
 Atherosclerosis Antibodies  >20 publications with TPA and Atherosclerosis
 Thrombosis Antibodies  >19 publications with TPA and Thrombosis
 Cerebral Infarction Antibodies  >14 publications with TPA and Cerebral Infarction
 Necrosis Antibodies  >14 publications with TPA and Necrosis
 Stroke Antibodies  >13 publications with TPA and Stroke
 Myocardial Infarction Antibodies  >12 publications with TPA and Myocardial Infarction
 Kidney Diseases Antibodies  >9 publications with TPA and Kidney Diseases
 Embolism and Thrombosis Antibodies  >9 publications with TPA and Embolism and Thrombosis
Organs/Tissues associated with TPA elisa kit
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >47 publications with TPA and Vascular
 Liver Antibodies  >44 publications with TPA and Liver
 Brain Antibodies  >37 publications with TPA and Brain
 Heart Antibodies  >36 publications with TPA and Heart
 Lung Antibodies  >29 publications with TPA and Lung
 Muscle Antibodies  >26 publications with TPA and Muscle
 Intestine Antibodies  >17 publications with TPA and Intestine
 Bone Antibodies  >17 publications with TPA and Bone
 Embryonic Tissue Antibodies  >16 publications with TPA and Embryonic Tissue
 Kidney Antibodies  >14 publications with TPA and Kidney
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