NP_001243731.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,487 Da
NCBI Official Full Name
40S ribosomal protein S3 isoform 1
NCBI Official Synonym Full Names
ribosomal protein S3
NCBI Official Synonym Symbols
NCBI Protein Information
40S ribosomal protein S3; IMR-90 ribosomal protein S3
UniProt Protein Name
40S ribosomal protein S3
UniProt Synonym Gene Names
UniProt Entry Name
RS3_HUMAN
NCBI Summary for RPS3
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
UniProt Comments for RPS3
RPS3: a component of the 40S ribosomal subunit of eukaryotes. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Overexpressed in colorectal cancer.
Protein type: RNA-binding; EC 4.2.99.18; Apoptosis; Translation; Ribosomal
Chromosomal Location of Human Ortholog: 11q13.3-q13.5
Cellular Component: focal adhesion; membrane; cytoplasm; mitochondrial inner membrane; nucleolus; spindle; nucleus; ribonucleoprotein complex; cytosol
Molecular Function: mRNA binding; NF-kappaB binding; protein binding; enzyme binding; DNA-(apurinic or apyrimidinic site) lyase activity; structural constituent of ribosome; protein kinase A binding; oxidized purine base lesion DNA N-glycosylase activity; damaged DNA binding; iron-sulfur cluster binding; protein kinase binding
Biological Process: SRP-dependent cotranslational protein targeting to membrane; mitosis; viral reproduction; translation; transcription, DNA-dependent; apoptosis; viral infectious cycle; translational termination; DNA repair; DNA catabolic process, endonucleolytic; activation of NF-kappaB transcription factor; regulation of translation; translational elongation; cellular protein metabolic process; cell division; translational initiation; mRNA catabolic process, nonsense-mediated decay; gene expression; viral transcription; negative regulation of DNA repair; response to DNA damage stimulus
Research Articles on RPS3
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Pathways associated with RPS3 elisa kit
Diseases associated with RPS3 elisa kit
Organs/Tissues associated with RPS3 elisa kit
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