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KCNJ8 elisa kit :: Guinea Pig ATP-sensitive inward rectifier potassium channel 8 (KCNJ8) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7209618 KCNJ8 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATP-sensitive inward rectifier potassium channel 8 (KCNJ8), ELISA Kit

 Also Known As   

Guinea pig ATP-sensitive inward rectifier potassium channel 8 (KCNJ8) ELISA Kit

 Product Gene Name   

KCNJ8 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    600935
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 Species Reactivity    Guinea Pig
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of KCNJ8 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for KCNJ8 purchase    MBS7209618 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the ATP-sensitive inward rectifier potassium channel 8 (KCNJ8) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KCNJ8. The ELISA analytical biochemical technique of the MBS7209618 kit is based on KCNJ8 antibody-KCNJ8 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KCNJ8 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KCNJ8. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for KCNJ8 elisa kit    Signal Transduction
NCBI/Uniprot data below describe general gene information for KCNJ8. It may not necessarily be applicable to this product.
 NCBI GI #    4826802
 NCBI GeneID    3764
 NCBI Accession #    NP_004973.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004982.3 [Other Products]
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 UniProt Secondary Accession #    O00657 [Other Products]
 UniProt Related Accession #    Q15842 [Other Products]
 Molecular Weight    47,968 Da
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 NCBI Official Full Name    ATP-sensitive inward rectifier potassium channel 8
 NCBI Official Synonym Full Names    potassium inwardly-rectifying channel, subfamily J, member 8
 NCBI Official Symbol    KCNJ8 [Similar Products]
 NCBI Official Synonym Symbols   
KIR6.1; uKATP-1
[Similar Products]
 NCBI Protein Information    ATP-sensitive inward rectifier potassium channel 8; inward rectifier K(+) channel Kir6.1; inwardly rectifying potassium channel KIR6.1; potassium channel, inwardly rectifying subfamily J member 8
 UniProt Protein Name    ATP-sensitive inward rectifier potassium channel 8
 UniProt Synonym Protein Names   
Inward rectifier K(+) channel Kir6.1; Potassium channel, inwardly rectifying subfamily J member 8; uKATP-1
 Protein Family    ATP-sensitive inward rectifier potassium channel
 UniProt Gene Name    KCNJ8 [Similar Products]
 UniProt Entry Name    KCNJ8_HUMAN
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 NCBI Summary for KCNJ8    Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS). [provided by RefSeq, May 2012]
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 UniProt Comments for KCNJ8    KCNJ8: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. Defects in KCNJ8 may be associated with susceptibility to J-wave syndromes, a group of heart disorders characterized by early repolarization events as indicated by abnormal J-wave manifestation on electrocardiogram (ECG). The J point denotes the junction of the QRS complex and the ST segment on the ECG, marking the end of depolarization and the beginning of repolarization. An abnormal J wave is a deflection with a dome or hump morphology immediately following the QRS complex of the surface ECG. Examples of J-wave disorders are arrhythmias associated with an early repolarization pattern in the inferior or mid to lateral precordial leads, Brugada syndrome, some cases of idiopathic ventricular fibrillation (VF) with an early repolarization pattern in the inferior, inferolateral or global leads, as well as arrhythmias associated with hypothermia. Defects in KCNJ8 may be a cause of susceptibility to sudden infant death syndrome (SIDS). SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ8 subfamily.

Protein type: Channel, potassium; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p11.23

Cellular Component: voltage-gated potassium channel complex; mitochondrion; myofibril; plasma membrane; ATP-sensitive potassium channel complex; sarcolemma

Molecular Function: G-protein activated inward rectifier potassium channel activity; ATP-activated inward rectifier potassium channel activity; sulfonylurea receptor binding; inward rectifier potassium channel activity; ATP binding

Biological Process: synaptic transmission; response to exogenous dsRNA; potassium ion import; heart development; response to lipopolysaccharide; kidney development; defense response to virus; vasodilation; potassium ion transport; response to pH
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 Research Articles on KCNJ8    1. KATP channels are up-regulated with increasing age in human myometrium
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with KCNJ8 elisa kitPathways associated with KCNJ8 elisa kit
 Reference Product  PubMed Publications
 KCNJ11 elisa kit  >12 publications with KCNJ8 and KCNJ11
 ABCC9 elisa kit  >12 publications with KCNJ8 and ABCC9
 ABCC8 elisa kit  >7 publications with KCNJ8 and ABCC8
 KCNJ2 elisa kit  >2 publications with KCNJ8 and KCNJ2
 KCNA4 elisa kit  >1 publications with KCNJ8 and KCNA4
 Products by Pathway  Pathway Diagram
 ATP Sensitive Potassium Channels Pathway antibodies  ATP Sensitive Potassium Channels Pathway Diagram
 Inwardly Rectifying K+ Channels Pathway antibodies  Inwardly Rectifying K+ Channels Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
 CGMP-PKG Signaling Pathway antibodies  CGMP-PKG Signaling Pathway Diagram
 CGMP-PKG Signaling Pathway antibodies  CGMP-PKG Signaling Pathway Diagram
Diseases associated with KCNJ8 elisa kitOrgans/Tissues associated with KCNJ8 elisa kit
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >17 publications with KCNJ8 and Cardiovascular Diseases
 Heart Diseases Antibodies  >12 publications with KCNJ8 and Heart Diseases
 Arrhythmias, Cardiac Antibodies  >10 publications with KCNJ8 and Arrhythmias, Cardiac
 Genetic Predisposition to Disease Antibodies  >8 publications with KCNJ8 and Genetic Predisposition to Disease
 Ventricular Fibrillation Antibodies  >6 publications with KCNJ8 and Ventricular Fibrillation
 Myocardial Ischemia Antibodies  >4 publications with KCNJ8 and Myocardial Ischemia
 Disease Models, Animal Antibodies  >3 publications with KCNJ8 and Disease Models, Animal
 Hypertrophy Antibodies  >2 publications with KCNJ8 and Hypertrophy
 Inflammation Antibodies  >2 publications with KCNJ8 and Inflammation
 Myocardial Infarction Antibodies  >2 publications with KCNJ8 and Myocardial Infarction
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >19 publications with KCNJ8 and Heart
 Brain Antibodies  >3 publications with KCNJ8 and Brain
 Mixed Antibodies  >1 publications with KCNJ8 and Mixed
 Ovary Antibodies  >1 publications with KCNJ8 and Ovary
 Kidney Antibodies  >1 publications with KCNJ8 and Kidney
 Lung Antibodies  >1 publications with KCNJ8 and Lung
 Embryonic Tissue Antibodies  >1 publications with KCNJ8 and Embryonic Tissue
 Thyroid Antibodies  >1 publications with KCNJ8 and Thyroid
 Uncharacterized Tissue Antibodies  >1 publications with KCNJ8 and Uncharacterized Tissue
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