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Bcl10 elisa kit :: Guinea Pig B-Cell CLL/Lymphoma 10 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS723203 Bcl10 elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

B-Cell CLL/Lymphoma 10 (Bcl10), ELISA Kit

 Also Known As   

Guinea Pig B-Cell CLL/Lymphoma 10 ELISA Kit

 Product Gene Name   

Bcl10 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 1; NC_000001.10 (85731459..85742587, complement). Location: 1p22
 OMIM    603517
 3D Structure    ModBase 3D Structure for O95999
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 Species Reactivity    Guinea Pig
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of Bcl10 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for Bcl10 purchase    MBS723203 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the B-Cell CLL/Lymphoma 10 (Bcl10) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Bcl10. The ELISA analytical biochemical technique of the MBS723203 kit is based on Bcl10 antibody-Bcl10 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Bcl10 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Bcl10. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for Bcl10 elisa kit    Immunology
NCBI/Uniprot data below describe general gene information for Bcl10. It may not necessarily be applicable to this product.
 NCBI GI #    4502379
 NCBI GeneID    8915
 NCBI Accession #    NP_003912.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003921.4 [Other Products]
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 UniProt Primary Accession #    O95999 [Other Products]
 UniProt Related Accession #    O95999; Q5VUF1 [Other Products]
 Molecular Weight    26,252 Da
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 NCBI Official Full Name    B-cell lymphoma/leukemia 10
 NCBI Official Synonym Full Names    B-cell CLL/lymphoma 10
 NCBI Official Symbol    BCL10 [Similar Products]
 NCBI Official Synonym Symbols   
CLAP; mE10; CIPER; c-E10; CARMEN
[Similar Products]
 NCBI Protein Information    B-cell lymphoma/leukemia 10; hCLAP; bcl-10; cCARMEN; cellular-E10; OTTHUMP00000011647; OTTHUMP00000036080; cellular homolog of vCARMEN; CARD-containing proapoptotic protein; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; caspase-recruiting domain-containing protein; CARD-containing molecule enhancing NF-kappa-B; mammalian CARD-containing adapter molecule E10; CED-3/ICH-1 prodomain homologous E10-like regulator
 UniProt Protein Name    B-cell lymphoma/leukemia 10
 UniProt Synonym Protein Names   
B-cell CLL/lymphoma 10; Bcl-10; CARD-containing molecule enhancing NF-kappa-B; CARD-like apoptotic protein; hCLAP; CED-3/ICH-1 prodomain homologous E10-like regulator; CIPER; Cellular homolog of vCARMEN; cCARMEN; Cellular-E10; c-E10; Mammalian CARD-containing adapter molecule E10
 Protein Family    B-cell lymphoma/leukemia
 UniProt Gene Name    BCL10 [Similar Products]
 UniProt Synonym Gene Names    CIPER; CLAP [Similar Products]
 UniProt Entry Name    BCL10_HUMAN
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 NCBI Summary for Bcl10    This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq]
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 UniProt Comments for Bcl10    Function: Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1. Ref.11

Subunit structure: Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Self-associates by CARD-CARD interaction and forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2.

Subcellular location: Cytoplasm › perinuclear region. Membrane raft. Note: Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts. Ref.10

Tissue specificity: Ubiquitous.

Post-translational modification: Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2. Ref.9

Involvement in disease: Note=A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.Note=Defects in BCL10 are involved in various types of cancer.

Sequence similarities: Contains 1 CARD domain.
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 Research Articles on Bcl10    1. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Bcl10 elisa kitPathways associated with Bcl10 elisa kit
 Reference Product  PubMed Publications
 MALT1 elisa kit  >181 publications with Bcl10 and MALT1
 CARD11 elisa kit  >72 publications with Bcl10 and CARD11
 CARD9 elisa kit  >24 publications with Bcl10 and CARD9
 CHUK elisa kit  >18 publications with Bcl10 and CHUK
 CARD10 elisa kit  >16 publications with Bcl10 and CARD10
 TRAF2 elisa kit  >12 publications with Bcl10 and TRAF2
 TLR4 elisa kit  >10 publications with Bcl10 and TLR4
 CASP9 elisa kit  >8 publications with Bcl10 and CASP9
 IKBKG elisa kit  >5 publications with Bcl10 and IKBKG
 CARD14 elisa kit  >5 publications with Bcl10 and CARD14
 Products by Pathway  Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram
Diseases associated with Bcl10 elisa kitOrgans/Tissues associated with Bcl10 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >209 publications with Bcl10 and Neoplasms
 Lymphoma Antibodies  >202 publications with Bcl10 and Lymphoma
 Lymphoma, B-Cell Antibodies  >173 publications with Bcl10 and Lymphoma, B-Cell
 Death Antibodies  >28 publications with Bcl10 and Death
 Necrosis Antibodies  >27 publications with Bcl10 and Necrosis
 Stomach Neoplasms Antibodies  >27 publications with Bcl10 and Stomach Neoplasms
 Leukemia Antibodies  >26 publications with Bcl10 and Leukemia
 Cell Transformation, Neoplastic Antibodies  >10 publications with Bcl10 and Cell Transformation, Neoplastic
 Adenocarcinoma Antibodies  >10 publications with Bcl10 and Adenocarcinoma
 Skin Diseases Antibodies  >10 publications with Bcl10 and Skin Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >103 publications with Bcl10 and Blood
 Stomach Antibodies  >38 publications with Bcl10 and Stomach
 Lung Antibodies  >15 publications with Bcl10 and Lung
 Intestine Antibodies  >13 publications with Bcl10 and Intestine
 Lymph Node Antibodies  >13 publications with Bcl10 and Lymph Node
 Nerve Antibodies  >11 publications with Bcl10 and Nerve
 Skin Antibodies  >9 publications with Bcl10 and Skin
 Bone Antibodies  >9 publications with Bcl10 and Bone
 Liver Antibodies  >8 publications with Bcl10 and Liver
 Bone Marrow Antibodies  >8 publications with Bcl10 and Bone Marrow
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