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BSND elisa kit :: Guinea Pig Barttin (BSND) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7247446 BSND elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Barttin (BSND), ELISA Kit

 Also Known As   

Guinea pig Barttin (BSND) ELISA Kit

 Product Gene Name   

BSND elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    606412
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 Species Reactivity    Guinea Pig
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of BSND elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for BSND purchase    MBS7247446 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Barttin (BSND) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing BSND. The ELISA analytical biochemical technique of the MBS7247446 kit is based on BSND antibody-BSND antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect BSND antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, BSND. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for BSND elisa kit    Signal Transduction
NCBI/Uniprot data below describe general gene information for BSND. It may not necessarily be applicable to this product.
 NCBI GI #    17017967
 NCBI GeneID    7809
 NCBI Accession #    NP_476517.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_057176.2 [Other Products]
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 UniProt Secondary Accession #    Q6NT28 [Other Products]
 UniProt Related Accession #    Q8WZ55 [Other Products]
 Molecular Weight    35,197 Da
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 NCBI Official Full Name    barttin
 NCBI Official Synonym Full Names    barttin CLCNK-type chloride channel accessory beta subunit
 NCBI Official Symbol    BSND [Similar Products]
 NCBI Official Synonym Symbols   
BART; DFNB73
[Similar Products]
 NCBI Protein Information    barttin; deafness, autosomal recessive 73; Bartter syndrome, infantile, with sensorineural deafness (Barttin)
 UniProt Protein Name    Barttin
 Protein Family    Barttin
 UniProt Gene Name    BSND [Similar Products]
 UniProt Synonym Gene Names    BART [Similar Products]
 UniProt Entry Name    BSND_HUMAN
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 NCBI Summary for BSND    This gene encodes an essential beta subunit for CLC chloride channels. These heteromeric channels localize to basolateral membranes of renal tubules and of potassium-secreting epithelia of the inner ear. Mutations in this gene have been associated with Bartter syndrome with sensorineural deafness. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BSND    BSND: Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter. Defects in BSND are the cause of Bartter syndrome type 4A (BS4A); also known as infantile Bartter syndrome with sensorineural deafness. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS4A is associated with sensorineural deafness.

Protein type: Transporter; Transporter, ion channel; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p32.1

Cellular Component: protein complex; integral to plasma membrane; basolateral plasma membrane; cytoplasm; plasma membrane

Molecular Function: chloride channel activity; chloride channel regulator activity

Biological Process: transmembrane transport

Disease: Bartter Syndrome, Type 4a
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 Research Articles on BSND    1. BSND, was first modeled, and then, the identified mutation was further analyzed by using different bioinformatics tools.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BSND elisa kitPathways associated with BSND elisa kit
 Reference Product  PubMed Publications
 CLCNKB elisa kit  >30 publications with BSND and CLCNKB
 CLCNKA elisa kit  >19 publications with BSND and CLCNKA
 KCNJ1 elisa kit  >9 publications with BSND and KCNJ1
 SLC12A1 elisa kit  >8 publications with BSND and SLC12A1
 SLC12A3 elisa kit  >2 publications with BSND and SLC12A3
 Products by Pathway  Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
Diseases associated with BSND elisa kitOrgans/Tissues associated with BSND elisa kit
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >42 publications with BSND and Kidney Diseases
 Bartter Syndrome Antibodies  >37 publications with BSND and Bartter Syndrome
 Hyperaldosteronism Antibodies  >33 publications with BSND and Hyperaldosteronism
 Deafness Antibodies  >30 publications with BSND and Deafness
 Ear Diseases Antibodies  >20 publications with BSND and Ear Diseases
 Hearing Loss Antibodies  >20 publications with BSND and Hearing Loss
 Hearing Disorders Antibodies  >19 publications with BSND and Hearing Disorders
 Hearing Loss, Sensorineural Antibodies  >12 publications with BSND and Hearing Loss, Sensorineural
 Hypokalemia Antibodies  >10 publications with BSND and Hypokalemia
 Renal Insufficiency Antibodies  >4 publications with BSND and Renal Insufficiency
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >36 publications with BSND and Kidney
 Mixed Antibodies  >1 publications with BSND and Mixed
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