NP_001159367.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,371 Da
NCBI Official Full Name
CD320 antigen isoform 2
NCBI Official Synonym Full Names
CD320 molecule
NCBI Protein Information
CD320 antigen; FDC-SM-8D6; 8D6 antigen; transcobalamin receptor; FDC-signaling molecule 8D6
UniProt Protein Name
CD320 antigen
UniProt Synonym Protein Names
8D6 antigen; FDC-signaling molecule 8D6; FDC-SM-8D6; Transcobalamin receptor; TCblR; CD_antigen: CD320
UniProt Synonym Gene Names
UniProt Entry Name
CD320_HUMAN
NCBI Summary for CD320
This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and is involved in B-cell proliferation and immunoglobulin secretion. Mutations in this gene are associated with methylmalonic aciduria. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]
UniProt Comments for CD320
CD320: Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin. Defects in CD320 are the cause of methylmalonic aciduria type TCblR (MMATC); also called methylmalonic aciduria due to transcobalamin receptor defect. MMATC is a metabolic disorder characterized by increased blood C3- acylcarnitine levels, elevated methylmalonate and homocysteine, and low uptake of transcobalamin-bound cobalamin, but normal conversion to adenosylcobalamin and methylcobalamin. Plasma vitamin B12 and total homocysteine are normal.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 19p13.3-p13.2
Cellular Component: membrane; endoplasmic reticulum; integral to membrane; plasma membrane; endosome membrane
Molecular Function: growth factor activity; cobalamin binding
Biological Process: vitamin metabolic process; cobalamin metabolic process; regulation of vitamin metabolic process; regulation of cell growth; water-soluble vitamin metabolic process
Disease: Methylmalonic Aciduria Due To Transcobalamin Receptor Defect
Research Articles on CD320
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with CD320 elisa kit
Pathways associated with CD320 elisa kit
Diseases associated with CD320 elisa kit
Organs/Tissues associated with CD320 elisa kit
|