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KCNMB2 elisa kit :: Guinea Pig Calcium-activated potassium channel subunit beta-2 (KCNMB2) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7238161 KCNMB2 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Calcium-activated potassium channel subunit beta-2 (KCNMB2), ELISA Kit

 Also Known As   

Guinea pig Calcium-activated potassium channel subunit beta-2 (KCNMB2) ELISA Kit

 Product Gene Name   

KCNMB2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    605214
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 Species Reactivity    Guinea Pig
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of KCNMB2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for KCNMB2 purchase    MBS7238161 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Calcium-activated potassium channel subunit beta-2 (KCNMB2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KCNMB2. The ELISA analytical biochemical technique of the MBS7238161 kit is based on KCNMB2 antibody-KCNMB2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KCNMB2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KCNMB2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for KCNMB2 elisa kit    Cardiovascular
NCBI/Uniprot data below describe general gene information for KCNMB2. It may not necessarily be applicable to this product.
 NCBI GI #    524589096
 NCBI GeneID    10242
 NCBI Accession #    NP_001265840.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001278911.1 [Other Products]
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 UniProt Related Accession #    Q9Y691 [Other Products]
 Molecular Weight    27,130 Da
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 NCBI Official Full Name    calcium-activated potassium channel subunit beta-2
 NCBI Official Synonym Full Names    potassium large conductance calcium-activated channel, subfamily M, beta member 2
 NCBI Official Symbol    KCNMB2 [Similar Products]
 NCBI Protein Information    calcium-activated potassium channel subunit beta-2; hbeta2; hCG1646471; slo-beta-2; k(VCA)beta-2; BK channel subunit beta-2; MaxiK channel beta 2 subunit; charybdotoxin receptor subunit beta-2; large-conductance Ca2+-activated K+ channel beta2 subunit; large conductance calcium-activated potassium channel beta 2 subunit
 UniProt Protein Name    Calcium-activated potassium channel subunit beta-2
 UniProt Synonym Protein Names   
BK channel subunit beta-2; BKbeta2; Hbeta2; Calcium-activated potassium channel, subfamily M subunit beta-2; Charybdotoxin receptor subunit beta-2; Hbeta3; K(VCA)beta-2; Maxi K channel subunit beta-2; Slo-beta-2
 Protein Family    Calcium-activated potassium channel
 UniProt Gene Name    KCNMB2 [Similar Products]
 UniProt Synonym Gene Names    BKbeta2; Hbeta2 [Similar Products]
 UniProt Entry Name    KCMB2_HUMAN
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 NCBI Summary for KCNMB2    MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013]
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 UniProt Comments for KCNMB2    KCNMB2: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q26.32

Cellular Component: voltage-gated potassium channel complex; integral to plasma membrane; plasma membrane

Molecular Function: calcium-activated potassium channel activity; potassium channel regulator activity; ion channel inhibitor activity

Biological Process: synaptic transmission; regulation of action potential; regulation of vasoconstriction; generation of action potential; detection of calcium ion; blood coagulation; potassium ion transport
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 Research Articles on KCNMB2    1. IFN-gamma changed mRNA levels of the BK beta-modulatory proteins KCNMB2 (increased) and KCNMB4 (decreased) as well as leucine-rich repeat-containing protein (LRRC)26 (decreased).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with KCNMB2 elisa kitDiseases associated with KCNMB2 elisa kit
 Products by Pathway  Pathway Diagram
 Ca2+ Activated K+ Channels Pathway antibodies  Ca2+ Activated K+ Channels Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Insulin Secretion Pathway antibodies  Insulin Secretion Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Nitric Oxide Stimulates Guanylate Cyclase Pathway antibodies  Nitric Oxide Stimulates Guanylate Cyclase Pathway Diagram
 Platelet Homeostasis Pathway antibodies  Platelet Homeostasis Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
 CGMP Effects Pathway antibodies  CGMP Effects Pathway Diagram
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >1 publications with KCNMB2 and Fibrosis
Organs/Tissues associated with KCNMB2 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with KCNMB2 and Lung
 Nerve Antibodies  >1 publications with KCNMB2 and Nerve
 Kidney Antibodies  >1 publications with KCNMB2 and Kidney
 Brain Antibodies  >1 publications with KCNMB2 and Brain
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