AAK92231.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,681 Da
NCBI Official Full Name
cardiac troponin T
NCBI Official Synonym Full Names
troponin T type 2 (cardiac)
NCBI Official Synonym Symbols
CMH2; RCM3; TnTC; cTnT; CMD1D; CMPD2; LVNC6 [Similar Products]
NCBI Protein Information
troponin T, cardiac muscle; troponin T2, cardiac; cardiomyopathy, hypertrophic 2; cardiomyopathy, dilated 1D (autosomal dominant)
UniProt Protein Name
Troponin T, cardiac muscle
UniProt Synonym Protein Names
Cardiac muscle troponin T; cTnT
UniProt Synonym Gene Names
UniProt Entry Name
TNNT2_HUMAN
NCBI Summary for cTnT
The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for cTnT
TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing.
Protein type: Motor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1q32
Cellular Component: sarcomere; troponin complex; cytosol; striated muscle thin filament
Molecular Function: troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; actin binding; tropomyosin binding
Biological Process: atrial cardiac muscle morphogenesis; metabolic process; positive regulation of ATPase activity; regulation of muscle contraction; ventricular cardiac muscle morphogenesis; sarcomere organization; response to calcium ion; negative regulation of ATPase activity; regulation of heart contraction; muscle filament sliding
Disease: Cardiomyopathy, Familial Restrictive, 3; Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2
Research Articles on cTnT
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Products associated with cTnT elisa kit
Pathways associated with cTnT elisa kit
Diseases associated with cTnT elisa kit
Disease Name |
Pubmed Publications |
Cardiovascular Diseases Antibodies |
>154 publications with cTnT and Cardiovascular Diseases |
Heart Diseases Antibodies |
>151 publications with cTnT and Heart Diseases |
Cardiomyopathies Antibodies |
>116 publications with cTnT and Cardiomyopathies |
Cardiomyopathy, Hypertrophic Antibodies |
>102 publications with cTnT and Cardiomyopathy, Hypertrophic |
Cardiomyopathy, Hypertrophic, Familial Antibodies |
>47 publications with cTnT and Cardiomyopathy, Hypertrophic, Familial |
Cardiomyopathy, Dilated Antibodies |
>44 publications with cTnT and Cardiomyopathy, Dilated |
Cardiomegaly Antibodies |
>41 publications with cTnT and Cardiomegaly |
Hypertrophy Antibodies |
>39 publications with cTnT and Hypertrophy |
Heart Failure Antibodies |
>35 publications with cTnT and Heart Failure |
Death, Sudden, Cardiac Antibodies |
>33 publications with cTnT and Death, Sudden, Cardiac |
Organs/Tissues associated with cTnT elisa kit
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