NP_001264.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
220,848 Da
NCBI Official Full Name
chromodomain-helicase-DNA-binding protein 4 isoform 1
NCBI Official Synonym Full Names
chromodomain helicase DNA binding protein 4
NCBI Protein Information
chromodomain-helicase-DNA-binding protein 4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein
UniProt Protein Name
Chromodomain-helicase-DNA-binding protein 4
UniProt Synonym Protein Names
ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein; Mi2-beta
UniProt Synonym Gene Names
UniProt Entry Name
CHD4_HUMAN
NCBI Summary for CHD4
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
UniProt Comments for CHD4
CHD-4: is an ATP-dependent helicase and a central component of the HDAC-containing nucleosome remodeling and histone deacetylase (NuRD) transcriptional complex. Interacts with MTA1/2, HDAC1, and RbAp46 in the NuRD complex. CHD-4 belongs to the SNF2/RAD54 helicase family of proteins. The NuRD complex, whose subunit composition varies by cell type and in response to physiologic signals, plays central roles in many processes including oncogenesis and metastasis, B cell differentiation, invasive growth of breast cancer, and maintaining the balance between the undifferentiated state and the process of differentiation in embryonic stem cells.
Protein type: EC 3.6.4.12; DNA-binding; Helicase
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: nucleoplasm; centrosome; protein complex; membrane; cytoplasm; nuclear chromatin; NuRD complex; nucleus
Molecular Function: ATP-dependent DNA helicase activity; protein binding; nucleosomal DNA binding; DNA binding; zinc ion binding; microtubule binding; ATP binding
Biological Process: regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; ATP-dependent chromatin remodeling; spindle assembly; DNA duplex unwinding
Research Articles on CHD4
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Products associated with CHD4 elisa kit
Pathways associated with CHD4 elisa kit
Diseases associated with CHD4 elisa kit
Organs/Tissues associated with CHD4 elisa kit
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