AAA52421.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,732 Da
NCBI Official Full Name
coagulation factor X
NCBI Official Synonym Full Names
coagulation factor X
NCBI Official Synonym Symbols
NCBI Protein Information
coagulation factor X; factor Xa; prothrombinase; Stuart-Prower factor
UniProt Protein Name
Coagulation factor X
UniProt Synonym Protein Names
Stuart factor; Stuart-Prower factorCleaved into the following 3 chains:Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain
UniProt Entry Name
FA10_HUMAN
NCBI Summary for F10
This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. [provided by RefSeq, Jul 2008]
UniProt Comments for F10
F10: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. Defects in F10 are the cause of factor X deficiency (FA10D). A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis. Belongs to the peptidase S1 family.
Protein type: Lipid-binding; Motility/polarity/chemotaxis; Protease; Secreted, signal peptide; Secreted; EC 3.4.21.6
Chromosomal Location of Human Ortholog: 13q34
Cellular Component: Golgi lumen; endoplasmic reticulum lumen; plasma membrane; extracellular region
Molecular Function: protein binding; serine-type endopeptidase activity; phospholipid binding; calcium ion binding
Biological Process: positive regulation of protein kinase B signaling cascade; blood coagulation, extrinsic pathway; cellular protein metabolic process; proteolysis; blood coagulation; post-translational protein modification; blood coagulation, intrinsic pathway; peptidyl-glutamic acid carboxylation; positive regulation of cell migration
Disease: Factor X Deficiency
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Pathways associated with F10 elisa kit
Diseases associated with F10 elisa kit
Organs/Tissues associated with F10 elisa kit
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