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COL3 elisa kit :: Guinea Pig Collagen Type III  (COL3) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS266999 COL3 elisa kit
Unit / Price
48-Strip-Wells  /  $300 +1 FREE 8GB USB
96-Strip-Wells  /  $475 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,825 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,425 +4 FREE 8GB USB
 
 Product Name   

Collagen Type III  (COL3), ELISA Kit

 Also Known As   

Guinea pig Collagen Type III (COL3) ELISA KIT

 Product Gene Name   

COL3 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    130050
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 Species Reactivity    Guinea Pig
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of COL3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for COL3 purchase    MBS266999 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Collagen Type III  (COL3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing COL3. The ELISA analytical biochemical technique of the MBS266999 kit is based on COL3 antibody-COL3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect COL3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, COL3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for COL3. It may not necessarily be applicable to this product.
 NCBI GI #    119631316
 NCBI GeneID    1281
 NCBI Accession #    EAX10911.1 [Other Products]
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 UniProt Secondary Accession #    P78429; Q15112; Q16403; Q53S91; Q541P8; Q6LDB3; Q6LDJ2; Q6LDJ3; Q7KZ56; D2JYH5; D3DPH4 [Other Products]
 UniProt Related Accession #    P02461 [Other Products]
 Molecular Weight    111,907 Da
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 NCBI Official Full Name    collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant), isoform CRA_b
 NCBI Official Synonym Full Names    collagen, type III, alpha 1
 NCBI Official Symbol    COL3A1 [Similar Products]
 NCBI Official Synonym Symbols   
EDS4A
[Similar Products]
 NCBI Protein Information    collagen alpha-1(III) chain; collagen alpha-1(III) chain; collagen, fetal; alpha1 (III) collagen; Ehlers-Danlos syndrome type IV, autosomal dominant
 UniProt Protein Name    Collagen alpha-1(III) chain
 Protein Family    Zinc finger protein CONSTANS
 UniProt Gene Name    COL3A1 [Similar Products]
 UniProt Entry Name    CO3A1_HUMAN
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 NCBI Summary for COL3    This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
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 UniProt Comments for COL3    CO3A1: Collagen type III occurs in most soft connective tissues along with type I collagen. Defects in COL3A1 are a cause of Ehlers-Danlos syndrome type 3 (EDS3); also known as benign hypermobility syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS3 is a form of Ehlers-Danlos syndrome characterized by marked joint hyperextensibility without skeletal deformity. Defects in COL3A1 are the cause of Ehlers-Danlos syndrome type 4 (EDS4). EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS4 is the most severe form of the disease. It is characterized by the joint and dermal manifestations as in other forms of the syndrome, characteristic facial features (acrogeria) in most patients, and by proneness to spontaneous rupture of bowel and large arteries. The vascular complications may affect all anatomical areas. Defects in COL3A1 are a cause of susceptibility to aortic aneurysm abdominal (AAA). AAA is a common multifactorial disorder characterized by permanent dilation of the abdominal aorta, usually due to degenerative changes in the aortic wall. Histologically, AAA is characterized by signs of chronic inflammation, destructive remodeling of the extracellular matrix, and depletion of vascular smooth muscle cells. Belongs to the fibrillar collagen family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis; Cell adhesion; Extracellular matrix

Chromosomal Location of Human Ortholog: 2q31

Cellular Component: extracellular matrix; extracellular space; endoplasmic reticulum lumen; extracellular region; collagen type III

Molecular Function: integrin binding; protein binding; platelet-derived growth factor binding; metal ion binding; extracellular matrix structural constituent; SMAD binding

Biological Process: integrin-mediated signaling pathway; skin development; axon guidance; platelet activation; receptor-mediated endocytosis; extracellular matrix organization and biogenesis; collagen fibril organization; wound healing; cell-matrix adhesion; heart development; negative regulation of immune response; positive regulation of Rho protein signal transduction; collagen catabolic process; extracellular matrix disassembly; response to radiation; gut development; response to mechanical stimulus; response to cytokine stimulus; transforming growth factor beta receptor signaling pathway; fibril organization and biogenesis; peptide cross-linking; cerebral cortex development; skeletal development; aging

Disease: Ehlers-danlos Syndrome, Type Iv, Autosomal Dominant; Ehlers-danlos Syndrome, Type Iii
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 Research Articles on COL3    1. Gal-1 decreased the expression of collagen genes COL3A1 and COL5A1 but increased the expression of fibronectin and laminin 5.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with COL3 elisa kitDiseases associated with COL3 elisa kit
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Endothelins Pathway antibodies  Endothelins Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >189 publications with COL3 and Cardiovascular Diseases
 Ehlers-Danlos Syndrome Antibodies  >163 publications with COL3 and Ehlers-Danlos Syndrome
 Fibrosis Antibodies  >81 publications with COL3 and Fibrosis
 Disease Models, Animal Antibodies  >35 publications with COL3 and Disease Models, Animal
 Inflammation Antibodies  >35 publications with COL3 and Inflammation
 Heart Diseases Antibodies  >28 publications with COL3 and Heart Diseases
 Hypertension Antibodies  >14 publications with COL3 and Hypertension
 Hypertrophy Antibodies  >12 publications with COL3 and Hypertrophy
 Necrosis Antibodies  >12 publications with COL3 and Necrosis
 Liver Diseases Antibodies  >9 publications with COL3 and Liver Diseases
Organs/Tissues associated with COL3 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >136 publications with COL3 and Vascular
 Connective Tissue Antibodies  >108 publications with COL3 and Connective Tissue
 Skin Antibodies  >106 publications with COL3 and Skin
 Blood Antibodies  >84 publications with COL3 and Blood
 Muscle Antibodies  >81 publications with COL3 and Muscle
 Bone Antibodies  >48 publications with COL3 and Bone
 Heart Antibodies  >40 publications with COL3 and Heart
 Lung Antibodies  >34 publications with COL3 and Lung
 Kidney Antibodies  >18 publications with COL3 and Kidney
 Uterus Antibodies  >16 publications with COL3 and Uterus
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