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CRKL elisa kit :: Guinea Pig Crk-like protein (CRKL) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7237269 CRKL elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Crk-like protein (CRKL), ELISA Kit

★Popular Item★
 Also Known As   

Guinea pig Crk-like protein (CRKL) ELISA Kit

 Product Gene Name   

CRKL elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    602007
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 Species Reactivity    Guinea Pig
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CRKL elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CRKL purchase    MBS7237269 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Crk-like protein (CRKL) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CRKL. The ELISA analytical biochemical technique of the MBS7237269 kit is based on CRKL antibody-CRKL antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CRKL antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CRKL. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for CRKL elisa kit    Neurobiology
NCBI/Uniprot data below describe general gene information for CRKL. It may not necessarily be applicable to this product.
 NCBI GI #    4885153
 NCBI GeneID    1399
 NCBI Accession #    NP_005198.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005207.3 [Other Products]
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 UniProt Secondary Accession #    A8KA44; D3DX35 [Other Products]
 UniProt Related Accession #    P46109 [Other Products]
 Molecular Weight    33,777 Da
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 NCBI Official Full Name    crk-like protein
 NCBI Official Synonym Full Names    v-crk avian sarcoma virus CT10 oncogene homolog-like
 NCBI Official Symbol    CRKL [Similar Products]
 NCBI Protein Information    crk-like protein
 UniProt Protein Name    Crk-like protein
 Protein Family    Crk-like protein
 UniProt Gene Name    CRKL [Similar Products]
 UniProt Entry Name    CRKL_HUMAN
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 NCBI Summary for CRKL    This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
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 UniProt Comments for CRKL    CRKL: an oncogenic adaptor protein with an SH2-SH3-SH3 domain structure. Plays a specific role in integrin-induced migration as a downstream mediator of Src. Activates the RAS and Jnk signaling pathways. Transforms fibroblasts in a RAS-dependent fashion. A substrate of BCR-ABL and plays a role in fibroblast transformation by BCR-ABL.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: cytosol; endosome

Molecular Function: protein binding; signal transducer activity; SH3/SH2 adaptor activity

Biological Process: anterior/posterior pattern formation; blood vessel development; organ morphogenesis; thymus development; nerve growth factor receptor signaling pathway; activation of MAPKK activity; heart development; Ras protein signal transduction; JNK cascade; parathyroid gland development
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 Research Articles on CRKL    1. results suggest that CRKL has the ability to regulate colon cancer malignancy and CRKL has the potential to serve as a diagnosis and prognosis marker and a therapy target of colon cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CRKL elisa kitPathways associated with CRKL elisa kit
 Reference Product  PubMed Publications
 BCR elisa kit  >159 publications with CRKL and BCR
 CBL elisa kit  >70 publications with CRKL and CBL
 ABL1 elisa kit  >10 publications with CRKL and ABL1
 BCAR1 elisa kit  >9 publications with CRKL and BCAR1
 PXN elisa kit  >9 publications with CRKL and PXN
 GAB2 elisa kit  >7 publications with CRKL and GAB2
 EPOR elisa kit  >6 publications with CRKL and EPOR
 CBLB elisa kit  >2 publications with CRKL and CBLB
 MAP4K1 elisa kit  >1 publications with CRKL and MAP4K1
 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
Diseases associated with CRKL elisa kitOrgans/Tissues associated with CRKL elisa kit
 Disease Name  Pubmed Publications
 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies  >87 publications with CRKL and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
 Leukemia, Myeloid, Acute Antibodies  >13 publications with CRKL and Leukemia, Myeloid, Acute
 Disease Models, Animal Antibodies  >12 publications with CRKL and Disease Models, Animal
 Craniofacial Abnormalities Antibodies  >12 publications with CRKL and Craniofacial Abnormalities
 Lung Neoplasms Antibodies  >12 publications with CRKL and Lung Neoplasms
 DiGeorge Syndrome Antibodies  >11 publications with CRKL and DiGeorge Syndrome
 Breast Neoplasms Antibodies  >7 publications with CRKL and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >7 publications with CRKL and Neoplasms, Experimental
 Inflammation Antibodies  >5 publications with CRKL and Inflammation
 Skin Diseases Antibodies  >5 publications with CRKL and Skin Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >101 publications with CRKL and Blood
 Bone Antibodies  >24 publications with CRKL and Bone
 Bone Marrow Antibodies  >21 publications with CRKL and Bone Marrow
 Nerve Antibodies  >20 publications with CRKL and Nerve
 Lung Antibodies  >19 publications with CRKL and Lung
 Brain Antibodies  >19 publications with CRKL and Brain
 Embryonic Tissue Antibodies  >12 publications with CRKL and Embryonic Tissue
 Heart Antibodies  >12 publications with CRKL and Heart
 Stomach Antibodies  >7 publications with CRKL and Stomach
 Liver Antibodies  >6 publications with CRKL and Liver
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