NP_071431.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,774 Da
NCBI Official Full Name
cytokine receptor-like factor 2 isoform 1
NCBI Official Synonym Full Names
cytokine receptor-like factor 2
NCBI Protein Information
cytokine receptor-like factor 2; IL-XR; TSLP receptor; cytokine receptor CRL2 precusor; thymic stromal lymphopoietin protein receptor; thymic stromal-derived lymphopoietin receptor
UniProt Protein Name
Cytokine receptor-like factor 2
UniProt Synonym Protein Names
Cytokine receptor-like 2; IL-XR; Thymic stromal lymphopoietin protein receptor; TSLP receptor
UniProt Synonym Gene Names
UniProt Entry Name
CRLF2_HUMAN
NCBI Summary for CRLF2
This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
UniProt Comments for CRLF2
CRLF2: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. Belongs to the type I cytokine receptor family. Type 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: Xp22.3; Yp11.3
Cellular Component: plasma membrane; integral to membrane; extracellular region
Research Articles on CRLF2
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Products associated with CRLF2 elisa kit
Pathways associated with CRLF2 elisa kit
Diseases associated with CRLF2 elisa kit
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