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GCK elisa kit :: Guinea Pig Glucokinase (GCK) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS268284 GCK elisa kit
Unit / Price
48-Strip-Wells  /  $315 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,825 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,425 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glucokinase (GCK), ELISA Kit

 Also Known As   

Guinea pig Glucokinase (GCK) ELISA Kit

 Product Gene Name   

GCK elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 Species Reactivity    Guinea Pig
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of GCK elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GCK purchase    MBS268284 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Glucokinase (GCK) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GCK. The ELISA analytical biochemical technique of the MBS268284 kit is based on GCK antibody-GCK antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GCK antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GCK. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for GCK. It may not necessarily be applicable to this product.
 NCBI GI #    31982798
 NCBI GeneID    103988
 NCBI Accession #    NP_034422.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_010292.5 [Other Products]
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 UniProt Secondary Accession #    P52791 [Other Products]
 UniProt Related Accession #    P52792 [Other Products]
 Molecular Weight    51,886 Da
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 NCBI Official Full Name    glucokinase isoform 1
 NCBI Official Synonym Full Names    glucokinase
 NCBI Official Symbol    Gck [Similar Products]
 NCBI Official Synonym Symbols   
Gk; GLK; HK4; HKIV; HXKP; MODY2; Gls006
[Similar Products]
 NCBI Protein Information    glucokinase; HK IV; hexokinase 4; hexokinase-4; hexokinase-D; hexokinase type IV
 UniProt Protein Name    Glucokinase
 UniProt Synonym Protein Names   
Hexokinase type IV; HK IV; Hexokinase-4; HK4; Hexokinase-D
 Protein Family    Glycerate 2-kinase
 UniProt Gene Name    Gck [Similar Products]
 UniProt Synonym Gene Names    Gk; HK IV; HK4 [Similar Products]
 UniProt Entry Name    HXK4_MOUSE
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 UniProt Comments for GCK    GK: a glycolytic enzyme that catalyzes glucose metabolism in the liver and pancreatic beta cells. Acts as a ""glucose sensor"" in beta cells. The first and rate-limiting step in glycosis, a pathway that produces energy in the form of ATP from glucose. Glucokinase traps glucose inside the cell by catalyzing its phosphorylation to produce glucose-6-phosphate. Has a lower affinity for glucose than the three other isozymes of hexokinase, allowing other organs such as the brain and muscles to have first call on glucose when its supply is limited. Unlike other hexokinases, glucokinase is not inhibited by glucose-6-phosphate. Glucokinase is found in the outer membrane compartment of mitochondria. May bind VDAC, suppressing mitochondrial function. Glucokinase transcription is induced by insulin, perhaps via the activation of Stat 5B. Mutant glucokinase causes a rare form of diabetes and may also play a role in type 2 diabetes. Three splice variant isoforms of human glucokinase have been described.

Protein type: Carbohydrate Metabolism - galactose; Mitochondrial; Kinase, other; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 2.7.1.2; Carbohydrate Metabolism - starch and sucrose

Cellular Component: nucleoplasm; mitochondrion; cell; cytoplasm; actin filament; cell cortex; basal cortex; nucleus; cytosol; secretory granule

Molecular Function: transferase activity; protein binding; hexokinase activity; nucleotide binding; magnesium ion binding; kinase activity; glucokinase activity; phosphotransferase activity, alcohol group as acceptor; ADP binding; protein phosphatase binding; ATP binding; glucose binding

Biological Process: positive regulation of glycogen biosynthetic process; glucose 6-phosphate metabolic process; lipid homeostasis; glucose homeostasis; NADP metabolic process; cellular response to glucose starvation; elevation of cytosolic calcium ion concentration; detection of glucose; negative regulation of gluconeogenesis; second-messenger-mediated signaling; glycogen biosynthetic process; glycolysis; regulation of potassium ion transport; glucose metabolic process; positive regulation of insulin secretion; fructose 2,6-bisphosphate metabolic process; cellular response to insulin stimulus; carbohydrate phosphorylation; carbohydrate metabolic process; positive regulation of glycolysis; negative regulation of epinephrine secretion; cell glucose homeostasis; phosphorylation; regulation of insulin secretion; positive regulation of phosphorylation
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 Research Articles on GCK    1. In the liver-specific glucokinase knockout mouse reduced expression of glucokinase in the liver induces diabetic cardiomyopathy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with GCK elisa kitDiseases associated with GCK elisa kit
 Products by Pathway  Pathway Diagram
 Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies  Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
 Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies  Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
 Butirosin And Neomycin Biosynthesis Pathway antibodies  Butirosin And Neomycin Biosynthesis Pathway Diagram
 Butirosin And Neomycin Biosynthesis Pathway antibodies  Butirosin And Neomycin Biosynthesis Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 GDP-glucose Biosynthesis Pathway antibodies  GDP-glucose Biosynthesis Pathway Diagram
 Galactose Metabolism Pathway antibodies  Galactose Metabolism Pathway Diagram
 Galactose Metabolism Pathway antibodies  Galactose Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Diabetes Mellitus, Type 2 Antibodies  >182 publications with GCK and Diabetes Mellitus, Type 2
 MATURITY-ONSET DIABETES OF THE YOUNG Antibodies  >123 publications with GCK and MATURITY-ONSET DIABETES OF THE YOUNG
 Hyperglycemia Antibodies  >106 publications with GCK and Hyperglycemia
 Congenital Hyperinsulinism Antibodies  >29 publications with GCK and Congenital Hyperinsulinism
 Necrosis Antibodies  >15 publications with GCK and Necrosis
 Cardiovascular Diseases Antibodies  >15 publications with GCK and Cardiovascular Diseases
 Hypertension Antibodies  >13 publications with GCK and Hypertension
 Neoplasms Antibodies  >13 publications with GCK and Neoplasms
 Fatty Liver Antibodies  >12 publications with GCK and Fatty Liver
 Kidney Diseases Antibodies  >11 publications with GCK and Kidney Diseases
Organs/Tissues associated with GCK elisa kit
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >144 publications with GCK and Blood
 Pancreas Antibodies  >94 publications with GCK and Pancreas
 Liver Antibodies  >57 publications with GCK and Liver
 Brain Antibodies  >23 publications with GCK and Brain
 Kidney Antibodies  >14 publications with GCK and Kidney
 Heart Antibodies  >12 publications with GCK and Heart
 Embryonic Tissue Antibodies  >5 publications with GCK and Embryonic Tissue
 Eye Antibodies  >4 publications with GCK and Eye
 Skin Antibodies  >4 publications with GCK and Skin
 Lung Antibodies  >2 publications with GCK and Lung
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