NP_005312.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,865 Da
NCBI Official Full Name
histone H1.4
NCBI Official Synonym Full Names
histone cluster 1, H1e
NCBI Official Synonym Symbols
H1E; H1.4; H1F4; H1s-4; dJ221C16.5 [Similar Products]
NCBI Protein Information
histone H1.4
UniProt Protein Name
Histone H1.4
UniProt Synonym Protein Names
Histone H1b; Histone H1s-4
UniProt Synonym Gene Names
UniProt Entry Name
H14_HUMAN
NCBI Summary for HIST1H1E
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
UniProt Comments for HIST1H1E
H1E: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: nuclear heterochromatin; nucleosome; nucleus
Molecular Function: chromatin DNA binding; protein binding
Biological Process: negative regulation of transcription from RNA polymerase II promoter; nucleosome assembly; nucleosome positioning
Research Articles on HIST1H1E
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Pathways associated with HIST1H1E elisa kit
Diseases associated with HIST1H1E elisa kit
Organs/Tissues associated with HIST1H1E elisa kit
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