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HYOU1 elisa kit :: Guinea Pig Hypoxia Up Regulated 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS724373
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $455 +1 FREE 8GB USB
96-Strip-Wells  /  $660 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hypoxia Up Regulated 1 (HYOU1), ELISA Kit

 Also Known As   

Guinea pig Hypoxia Up Regulated 1 ELISA Kit

 Product Gene Name   

HYOU1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    601746
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 Species Reactivity    Guinea Pig
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
 Assay Type    Competitive
 Detection Range    0.5-10ng/mL
 Sensitivity    0.1ng/mL
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of HYOU1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for HYOU1 purchase    MBS724373 is a ready-to-use microwell, strip plate Competitive ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Hypoxia Up Regulated 1 (HYOU1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.5-10ng/mL in biological research samples containing HYOU1, with an estimated sensitivity of 0.1ng/mL. The ELISA analytical biochemical technique of the MBS724373 kit is based on HYOU1 antibody-HYOU1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect HYOU1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, HYOU1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Typical Testing Data/Standard Curve (for reference only) of HYOU1 elisa kit    HYOU1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS724373. Click to request current manual
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NCBI/Uniprot data below describe general gene information for HYOU1. It may not necessarily be applicable to this product.
 NCBI GI #    195976805
 NCBI GeneID    10525
 NCBI Accession #    NP_001124463.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001130991.2 [Other Products]
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 UniProt Secondary Accession #    Q2I204; Q53H25; A8C1Z0 [Other Products]
 UniProt Related Accession #    Q9Y4L1 [Other Products]
 Molecular Weight    111,335 Da
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 NCBI Official Full Name    hypoxia up-regulated protein 1
 NCBI Official Synonym Full Names    hypoxia up-regulated 1
 NCBI Official Symbol    HYOU1 [Similar Products]
 NCBI Official Synonym Symbols   
Grp170; HSP12A; ORP150; GRP-170; ORP-150
[Similar Products]
 NCBI Protein Information    hypoxia up-regulated protein 1; 150 kDa oxygen-regulated protein; oxygen regulated protein (150kD); 170 kDa glucose-regulated protein
 UniProt Protein Name    Hypoxia up-regulated protein 1
 UniProt Synonym Protein Names   
150 kDa oxygen-regulated protein; ORP-150; 170 kDa glucose-regulated protein; GRP-170
 Protein Family    Hypoxia up-regulated protein
 UniProt Gene Name    HYOU1 [Similar Products]
 UniProt Synonym Gene Names    GRP170; ORP150; ORP-150; GRP-170 [Similar Products]
 UniProt Entry Name    HYOU1_HUMAN
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 NCBI Summary for HYOU1    The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
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 UniProt Comments for HYOU1    HYOU1: Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding. Belongs to the heat shock protein 70 family.

Protein type: Chaperone; Heat shock protein

Chromosomal Location of Human Ortholog: 11q23.1-q23.3

Cellular Component: focal adhesion; smooth endoplasmic reticulum; membrane; endoplasmic reticulum lumen; endoplasmic reticulum; extracellular region

Molecular Function: chaperone binding; ATP binding

Biological Process: receptor-mediated endocytosis; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; unfolded protein response
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 Research Articles on HYOU1    1. Here we show that Grp170 can bind directly to a variety of incompletely folded protein substrates in the endoplasmic reticulum, and as expected for a bona fide chaperone, it does not interact with folded secretory proteins.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HYOU1 elisa kitPathways associated with HYOU1 elisa kit
 Reference Product  PubMed Publications
 HSPA5 elisa kit  >7 publications with HYOU1 and HSPA5
 SIL1 elisa kit  >2 publications with HYOU1 and SIL1
 CALR elisa kit  >1 publications with HYOU1 and CALR
 HSP90B1 elisa kit  >1 publications with HYOU1 and HSP90B1
 DNAJC3 elisa kit  >1 publications with HYOU1 and DNAJC3
 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 IRE1alpha Activates Chaperones Pathway antibodies  IRE1alpha Activates Chaperones Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Scavenging By Class F Receptors Pathway antibodies  Scavenging By Class F Receptors Pathway Diagram
 Unfolded Protein Response (UPR) Pathway antibodies  Unfolded Protein Response (UPR) Pathway Diagram
 XBP1(S) Activates Chaperone Genes Pathway antibodies  XBP1(S) Activates Chaperone Genes Pathway Diagram
Diseases associated with HYOU1 elisa kitOrgans/Tissues associated with HYOU1 elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with HYOU1 and Nervous System Diseases
 Disease Models, Animal Antibodies  >3 publications with HYOU1 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >3 publications with HYOU1 and Neoplasms, Experimental
 Fibrosis Antibodies  >2 publications with HYOU1 and Fibrosis
 Inflammation Antibodies  >2 publications with HYOU1 and Inflammation
 Genital Diseases, Male Antibodies  >2 publications with HYOU1 and Genital Diseases, Male
 Proteinuria Antibodies  >1 publications with HYOU1 and Proteinuria
 Prostatic Diseases Antibodies  >1 publications with HYOU1 and Prostatic Diseases
 Liver Diseases Antibodies  >1 publications with HYOU1 and Liver Diseases
 Fatty Liver Antibodies  >1 publications with HYOU1 and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with HYOU1 and Brain
 Kidney Antibodies  >3 publications with HYOU1 and Kidney
 Blood Antibodies  >2 publications with HYOU1 and Blood
 Connective Tissue Antibodies  >2 publications with HYOU1 and Connective Tissue
 Prostate Antibodies  >2 publications with HYOU1 and Prostate
 Lymph Node Antibodies  >2 publications with HYOU1 and Lymph Node
 Nerve Antibodies  >2 publications with HYOU1 and Nerve
 Lymph Antibodies  >2 publications with HYOU1 and Lymph
 Ovary Antibodies  >1 publications with HYOU1 and Ovary
 Pancreas Antibodies  >1 publications with HYOU1 and Pancreas
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