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IFI16 elisa kit :: Guinea Pig Interferon Gamma Inducible Protein 16 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS722625 IFI16 elisa kit
Unit / Price
48-Strip-Wells  /  $455 +1 FREE 8GB USB
96-Strip-Wells  /  $660 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interferon Gamma Inducible Protein 16 (IFI16), ELISA Kit

 Also Known As   

Guinea pig Interferon Gamma Inducible Protein 16 ELISA Kit

 Product Gene Name   

IFI16 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    147586
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 Species Reactivity    Guinea Pig
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
 Assay Type    Competitive
 Detection Range    50-1000pg/mL
 Sensitivity    1.0pg/mL
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of IFI16 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for IFI16 purchase    MBS722625 is a ready-to-use microwell, strip plate Competitive ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Interferon Gamma Inducible Protein 16 (IFI16) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 50-1000pg/mL in biological research samples containing IFI16, with an estimated sensitivity of 1.0pg/mL. The ELISA analytical biochemical technique of the MBS722625 kit is based on IFI16 antibody-IFI16 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IFI16 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IFI16. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for IFI16 elisa kit    Cancer
NCBI/Uniprot data below describe general gene information for IFI16. It may not necessarily be applicable to this product.
 NCBI GI #    330864753
 NCBI GeneID    3428
 NCBI Accession #    NP_001193496.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001206567.1 [Other Products]
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 UniProt Secondary Accession #    Q59GX0; Q5T3W7; Q5T3W8; Q5T3X0; Q5T3X1; Q5T3X2; Q8N9E5; Q8NEQ7; Q96AJ5; B4DJT8; H3BLV7 [Other Products]
 UniProt Related Accession #    Q16666 [Other Products]
 Molecular Weight    82,588 Da
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 NCBI Official Full Name    gamma-interferon-inducible protein 16 isoform 1
 NCBI Official Synonym Full Names    interferon, gamma-inducible protein 16
 NCBI Official Symbol    IFI16 [Similar Products]
 NCBI Official Synonym Symbols   
PYHIN2; IFNGIP1
[Similar Products]
 NCBI Protein Information    gamma-interferon-inducible protein 16; interferon-gamma induced protein IFI 16; interferon-inducible myeloid differentiation transcriptional activator
 UniProt Protein Name    Gamma-interferon-inducible protein 16
 UniProt Synonym Protein Names   
Interferon-inducible myeloid differentiation transcriptional activator
 Protein Family    Gamma-interferon-inducible protein
 UniProt Gene Name    IFI16 [Similar Products]
 UniProt Synonym Gene Names    IFNGIP1; Ifi-16 [Similar Products]
 UniProt Entry Name    IF16_HUMAN
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 NCBI Summary for IFI16    This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]
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 UniProt Comments for IFI16    IFI16: a nuclear protein that may function as a transcriptional repressor. Strongly induced by gamma interferon and, to a lesser extent, by alpha interferon. Binds double-stranded DNA and cell cycle regulatory factors including p53 and Rb. Loss of IFI16 activates p53 checkpoint through NBS1-DNAPK pathway. Inhibits cell growth in the Ras/Raf signaling pathway. May be involved in the senescence of prostate epithelial cells. Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells. Present in myeloid precursors (CD34+) and throughout monocyte development, but its expression is down-regulated in erythroid and polymorphonuclear precursor cells. Present in prostate, ovary and breast. Four alternatively spliced isoforms have been described. Isoforms-1, -2 and -3 can homo- and hetero-dimerize.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; nuclear speck; cytosol; nucleus

Molecular Function: identical protein binding; protein binding; double-stranded DNA binding; transcription factor binding

Biological Process: positive regulation of cytokine production; transcription, DNA-dependent; monocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic; negative regulation of DNA binding; cell proliferation; positive regulation of interleukin-1 beta production; cellular response to glucose starvation; negative regulation of viral genome replication; negative regulation of innate immune response; positive regulation of interferon type I production; autophagy; innate immune response; hemopoiesis; regulation of autophagy; positive regulation of transcription from RNA polymerase II promoter; myeloid cell differentiation; negative regulation of transcription, DNA-dependent; inflammatory response; defense response to virus; activation of innate immune response; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
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 Research Articles on IFI16    1. The results of this study showed that IFI16 variants do not contribute to multiple sclerosis susceptibility.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with IFI16 elisa kitDiseases associated with IFI16 elisa kit
 Products by Pathway  Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 IRF3-mediated Induction Of Type I IFN Pathway antibodies  IRF3-mediated Induction Of Type I IFN Pathway Diagram
 Id Signaling Pathway antibodies  Id Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 STING Mediated Induction Of Host Immune Responses Pathway antibodies  STING Mediated Induction Of Host Immune Responses Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >25 publications with IFI16 and Inflammation
 Carcinoma, Squamous Cell Antibodies  >6 publications with IFI16 and Carcinoma, Squamous Cell
 Adenocarcinoma Antibodies  >6 publications with IFI16 and Adenocarcinoma
 Breast Neoplasms Antibodies  >5 publications with IFI16 and Breast Neoplasms
 Ataxia Antibodies  >4 publications with IFI16 and Ataxia
 Brain Diseases Antibodies  >3 publications with IFI16 and Brain Diseases
 Cell Transformation, Neoplastic Antibodies  >3 publications with IFI16 and Cell Transformation, Neoplastic
 Prostatic Neoplasms Antibodies  >3 publications with IFI16 and Prostatic Neoplasms
 Carcinoma, Hepatocellular Antibodies  >3 publications with IFI16 and Carcinoma, Hepatocellular
 Necrosis Antibodies  >3 publications with IFI16 and Necrosis
Organs/Tissues associated with IFI16 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >33 publications with IFI16 and Blood
 Bone Antibodies  >13 publications with IFI16 and Bone
 Muscle Antibodies  >12 publications with IFI16 and Muscle
 Skin Antibodies  >10 publications with IFI16 and Skin
 Heart Antibodies  >8 publications with IFI16 and Heart
 Lung Antibodies  >7 publications with IFI16 and Lung
 Prostate Antibodies  >5 publications with IFI16 and Prostate
 Kidney Antibodies  >4 publications with IFI16 and Kidney
 Liver Antibodies  >4 publications with IFI16 and Liver
 Bone Marrow Antibodies  >4 publications with IFI16 and Bone Marrow
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