NP_653090.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
3,653 Da
NCBI Official Full Name
kallikrein-8 isoform 4
NCBI Official Synonym Full Names
kallikrein-related peptidase 8
NCBI Protein Information
kallikrein-8; ovasin; serine protease 19; serine protease TADG-14; tumor-associated differentially expressed gene 14 protein
UniProt Protein Name
Kallikrein-8
UniProt Synonym Protein Names
Neuropsin; NP; Ovasin; Serine protease 19; Serine protease TADG-14; Tumor-associated differentially expressed gene 14 protein
UniProt Synonym Gene Names
UniProt Entry Name
KLK8_HUMAN
NCBI Summary for KLK8
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
UniProt Comments for KLK8
KLK8: Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer- collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. Belongs to the peptidase S1 family. Kallikrein subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.21.118; Protease; Secreted; Cell development/differentiation; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19q13
Cellular Component: extracellular space; cytoplasm
Molecular Function: protein binding; serine-type endopeptidase activity
Biological Process: cell death; negative regulation of myelination; negative regulation of axon regeneration; synapse organization and biogenesis; response to wounding; regulation of synapse organization and biogenesis; keratinocyte proliferation; proteolysis; neurite morphogenesis; memory
Research Articles on KLK8
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Pathways associated with KLK8 elisa kit
Diseases associated with KLK8 elisa kit
Organs/Tissues associated with KLK8 elisa kit
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