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PROC elisa kit :: Guinea Pig Protein C ELISA Kit

Scan QR to view Datasheet Catalog #    MBS265222
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $300 +1 FREE 8GB USB
96-Strip-Wells  /  $475 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,825 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,425 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Protein C (PROC), ELISA Kit

★Popular Item★
 Also Known As   

Guinea pig Protein C ELISA Kit

 Product Gene Name   

PROC elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 612304
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 Species Reactivity    Guinea Pig
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 Samples    Guinea pig serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant PC concentration
 Assay Type    Sandwich
 Detection Range    20 ng/ml-0.312 ng/ml
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PROC elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PROC purchase    MBS265222 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Protein C (PROC) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 20 ng/ml-0.312 ng/ml in biological research samples containing PROC. The ELISA analytical biochemical technique of the MBS265222 kit is based on PROC antibody-PROC antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PROC antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PROC. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Guinea pig serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant PC concentration. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for PROC elisa kit

   Principle of the Assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is Guinea pig PC monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.
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 Typical Testing Data/Standard Curve (for reference only) of PROC elisa kit    PROC elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS265222. Click to request current manual
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NCBI/Uniprot data below describe general gene information for PROC. It may not necessarily be applicable to this product.
 NCBI GI #    265668
 NCBI GeneID    5624
 NCBI Accession #    AAB25410.1 [Other Products]
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 UniProt Secondary Accession #    Q15189; Q15190; Q16001; Q53S74; Q9UC55; B4DPQ7 [Other Products]
 UniProt Related Accession #    P04070 [Other Products]
 Molecular Weight    57,556 Da [Similar Products]
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 NCBI Official Full Name    protein C, partial
 NCBI Official Synonym Full Names    protein C (inactivator of coagulation factors Va and VIIIa)
 NCBI Official Symbol    PROC [Similar Products]
 NCBI Official Synonym Symbols   
PC; APC; PROC1; THPH3; THPH4
[Similar Products]
 NCBI Protein Information    vitamin K-dependent protein C; prepro-protein C; autoprothrombin IIA; anticoagulant protein C; blood coagulation factor XIV
 UniProt Protein Name    Vitamin K-dependent protein C
 UniProt Synonym Protein Names   
Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIVCleaved into the following 3 chains:Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide
 Protein Family    Protein
 UniProt Gene Name    PROC [Similar Products]
 UniProt Entry Name    PROC_HUMAN
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 NCBI Summary for PROC    This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]
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 UniProt Comments for PROC    PROC: Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Defects in PROC are the cause of thrombophilia due to protein C deficiency, autosomal dominant (THPH3). A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Individuals with decreased amounts of protein C are classically referred to as having type I protein C deficiency and those with normal amounts of a functionally defective protein as having type II deficiency. Defects in PROC are the cause of thrombophilia due to protein C deficiency, autosomal recessive (THPH4). A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. It results in a thrombotic condition that can manifest as a severe neonatal disorder or as a milder disorder with late-onset thrombophilia. The severe form leads to neonatal death through massive neonatal venous thrombosis. Often associated with ecchymotic skin lesions which can turn necrotic called purpura fulminans, this disorder is very rare. Belongs to the peptidase S1 family.

Protein type: EC 3.4.21.69; Apoptosis; Protease

Chromosomal Location of Human Ortholog: 2q13-q14

Cellular Component: endoplasmic reticulum lumen; Golgi lumen; extracellular region

Molecular Function: protein binding; serine-type endopeptidase activity; calcium ion binding

Biological Process: cellular protein metabolic process; negative regulation of blood coagulation; post-translational protein modification; proteolysis; blood coagulation; leukocyte migration; peptidyl-glutamic acid carboxylation; negative regulation of apoptosis

Disease: Thrombophilia Due To Protein C Deficiency, Autosomal Recessive; Thrombophilia Due To Protein C Deficiency, Autosomal Dominant
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 Research Articles on PROC    1. The PROC TAA haplotype was associated with a high protein C level and increased risk of venous thrombosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PROC elisa kitPathways associated with PROC elisa kit
 Reference Product  PubMed Publications
 FURIN elisa kit  >53 publications with PROC and FURIN
 PF4 elisa kit  >11 publications with PROC and PF4
 GGCX elisa kit  >6 publications with PROC and GGCX
 SERPINA5 elisa kit  >5 publications with PROC and SERPINA5
 PROCR elisa kit  >3 publications with PROC and PROCR
 THBD elisa kit  >2 publications with PROC and THBD
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Common Pathway antibodies  Common Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Gamma-carboxylation Of Protein Precursors Pathway antibodies  Gamma-carboxylation Of Protein Precursors Pathway Diagram
 Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway antibodies  Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
Diseases associated with PROC elisa kitOrgans/Tissues associated with PROC elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >20816 publications with PROC and Neoplasms
 Cardiovascular Diseases Antibodies  >12570 publications with PROC and Cardiovascular Diseases
 Kidney Diseases Antibodies  >7271 publications with PROC and Kidney Diseases
 Liver Diseases Antibodies  >5858 publications with PROC and Liver Diseases
 Heart Diseases Antibodies  >5505 publications with PROC and Heart Diseases
 Inflammation Antibodies  >3723 publications with PROC and Inflammation
 Necrosis Antibodies  >3009 publications with PROC and Necrosis
 Drug Toxicity Antibodies  >2976 publications with PROC and Drug Toxicity
 Hypertension Antibodies  >2962 publications with PROC and Hypertension
 Cell Transformation, Neoplastic Antibodies  >2434 publications with PROC and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >23701 publications with PROC and Kidney
 Brain Antibodies  >20356 publications with PROC and Brain
 Liver Antibodies  >19077 publications with PROC and Liver
 Lung Antibodies  >6571 publications with PROC and Lung
 Spleen Antibodies  >4046 publications with PROC and Spleen
 Connective Tissue Antibodies  >3145 publications with PROC and Connective Tissue
 Uterus Antibodies  >1293 publications with PROC and Uterus
 Testis Antibodies  >1225 publications with PROC and Testis
 Mammary Gland Antibodies  >518 publications with PROC and Mammary Gland
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