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TGFbeta1 elisa kit :: Guinea Pig Transforming Growth Factor beta1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS725844
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells-(Competitive)  /  $455 +1 FREE 8GB USB
48-Strip-Wells-(Sandwich)  /  $455 +1 FREE 8GB USB
96-Strip-Wells-(Competitive)  /  $660 +1 FREE 8GB USB
96-Strip-Wells-(Sandwich)  /  $660 +1 FREE 8GB USB
5x96-Strip-Wells-(Competitive)  /  $2,925 +3 FREE 8GB USB
5x96-Strip-Wells-(Sandwich)  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells-(Competitive)  /  $5,490 +6 FREE 8GB USB
10x96-Strip-Wells-(Sandwich)  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Transforming Growth Factor beta1 (TGFbeta1), ELISA Kit

 Also Known As   

Guinea pig Transforming Growth Factor beta1 ELISA Kit

 Product Synonym Names    Guinea pig Transforming Growth Factor b1 ELISA Kit
 Product Gene Name   

TGFbeta1 elisa kit

[Similar Products]
 Product Synonym Gene Name    TGFb1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    190180
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 Species Reactivity    Guinea Pig
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
 Assay Type    Competitive or Sandwich
 Detection Range    50-1000pg/mL
 Sensitivity    1.0pg/mL
 Highest Standards    2500 pg/mL
 Concentration of Standards    Concentration of Standards
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TGFbeta1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TGFbeta1 purchase    MBS725844 is a ready-to-use microwell, strip plate Competitive or Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Transforming Growth Factor beta1 (TGFbeta1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 50-1000pg/mL in biological research samples containing TGFbeta1, with an estimated sensitivity of 1.0pg/mL. The ELISA analytical biochemical technique of the MBS725844 kit is based on TGFbeta1 antibody-TGFbeta1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TGFbeta1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TGFbeta1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for TGFbeta1 elisa kit    Cancer
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 Typical Testing Data/Standard Curve (for reference only) of TGFbeta1 elisa kit    TGFbeta1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS725844. Click to request current manual
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NCBI/Uniprot data below describe general gene information for TGFbeta1. It may not necessarily be applicable to this product.
 NCBI GI #    63025222
 NCBI GeneID    7040
 NCBI Accession #    NP_000651.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000660.5 [Other Products]
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 UniProt Secondary Accession #    Q9UCG4; A8K792 [Other Products]
 UniProt Related Accession #    P01137 [Other Products]
 Molecular Weight    44,341 Da
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 NCBI Official Full Name    transforming growth factor beta-1
 NCBI Official Synonym Full Names    transforming growth factor, beta 1
 NCBI Official Symbol    TGFB1 [Similar Products]
 NCBI Official Synonym Symbols   
CED; LAP; DPD1; TGFB; TGFbeta
[Similar Products]
 NCBI Protein Information    transforming growth factor beta-1; TGF-beta-1; latency-associated peptide; prepro-transforming growth factor beta-1
 UniProt Protein Name    Transforming growth factor beta-1
 UniProt Gene Name    TGFB1 [Similar Products]
 UniProt Synonym Gene Names    TGFB; TGF-beta-1; LAP [Similar Products]
 UniProt Entry Name    TGFB1_HUMAN
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 NCBI Summary for TGFbeta1    This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.[provided by RefSeq, Oct 2009]
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 UniProt Comments for TGFbeta1    TGFB1: Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Homodimer; disulfide-linked, or heterodimer with TGFB2. Secreted and stored as a biologically inactive form in the extracellular matrix in a 290 kDa complex (large latent TGF-beta1 complex) containing the TGFB1 homodimer, the latency-associated peptide (LAP), and the latent TGFB1 binding protein-1 (LTBP1). The complex without LTBP1 is known as the'small latent TGF-beta1 complex'. Dissociation of the TGFB1 from LAP is required for growth factor activation and biological activity. Release of the large latent TGF-beta1 complex from the extracellular matrix is carried out by the matrix metalloproteinase MMP3. May interact with THSD4; this interaction may lead to sequestration by FBN1 microfibril assembly and attenuation of TGFB signaling. Interacts with the serine proteases, HTRA1 and HTRA3: the interaction with either inhibits TGFB1-mediated signaling. The HTRA protease activity is required for this inhibition. Interacts with CD109, DPT and ASPN. Activated in vitro at pH below 3.5 and over 12.5. Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Co-localizes with ASPN in chondrocytes within OA lesions of articular cartilage. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: extracellular space; proteinaceous extracellular matrix; cell surface; microvillus; cell soma; axon; Golgi lumen; cytoplasm; plasma membrane; extracellular region; nucleus

Molecular Function: protein binding; enzyme binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity; punt binding; cytokine activity; protein N-terminus binding; glycoprotein binding; antigen binding

Biological Process: extracellular matrix organization and biogenesis; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; female pregnancy; SMAD protein nuclear translocation; positive regulation of protein amino acid dephosphorylation; activation of NF-kappaB transcription factor; regulation of protein import into nucleus; positive regulation of MAP kinase activity; connective tissue replacement during inflammatory response; regulation of transforming growth factor beta receptor signaling pathway; negative regulation of ossification; cell cycle arrest; positive regulation of isotype switching to IgA isotypes; inner ear development; regulatory T cell differentiation; positive regulation of interleukin-17 production; response to drug; positive regulation of smooth muscle cell differentiation; positive regulation of chemotaxis; active induction of host immune response by virus; positive regulation of blood vessel endothelial cell migration; regulation of sodium ion transport; negative regulation of blood vessel endothelial cell migration; negative regulation of fat cell differentiation; lymph node development; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; response to progesterone stimulus; endoderm development; myelination; positive regulation of odontogenesis; negative regulation of phagocytosis; evasion of host defenses by virus; positive regulation of cellular protein metabolic process; myeloid dendritic cell differentiation; negative regulation of transcription from RNA polymerase II promoter; phosphate metabolic process; negative regulation of cell proliferation; negative regulation of T cell proliferation; regulation of DNA binding; ureteric bud development; negative regulation of release of sequestered calcium ion into cytosol; salivary gland morphogenesis; positive regulation of cell proliferation; protein kinase B signaling cascade; protein export from nucleus; inflammatory response; aging; positive regulation of exit from mitosis; epidermal growth factor receptor signaling pathway; mitotic cell cycle checkpoint; common-partner SMAD protein phosphorylation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of bone mineralization; positive regulation of peptidyl-serine phosphorylation; SMAD protein complex assembly; positive regulation of protein kinase B signaling cascade; positive regulation of protein complex assembly; positive regulation of protein import into nucleus; response to hypoxia; epithelial to mesenchymal transition; negative regulation of cell-cell adhesion; negative regulation of cell growth; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of skeletal muscle development; mononuclear cell proliferation; protein amino acid phosphorylation; regulation of cell migration; hyaluronan catabolic process; regulation of apoptosis; response to vitamin D; negative regulation of neuroblast proliferation; transforming growth factor beta receptor signaling pathway; receptor catabolic process; positive regulation of superoxide release; germ cell migration; response to glucose stimulus; chondrocyte differentiation; defense response to fungus, incompatible interaction; T cell homeostasis; negative regulation of mitotic cell cycle; cell growth; tolerance induction to self antigen; regulation of striated muscle development; platelet activation; organ regeneration; negative regulation of DNA replication; virus-host interaction; hemopoietic progenitor cell differentiation; negative regulation of transcription, DNA-dependent; positive regulation of epithelial cell proliferation; positive regulation of collagen biosynthetic process; viral infectious cycle; response to estradiol stimulus; negative regulation of cell cycle; positive regulation of histone deacetylation; response to radiation; platelet degranulation; negative regulation of protein amino acid phosphorylation; response to wounding; lipopolysaccharide-mediated signaling pathway; adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; negative regulation of epithelial cell proliferation; intercellular junction assembly and maintenance; regulation of binding; MAPKKK cascade; cellular calcium ion homeostasis; gut development; protein import into nucleus, translocation; ATP biosynthetic process; positive regulation of histone acetylation; positive regulation of protein amino acid phosphorylation; blood coagulation; negative regulation of myoblast differentiation; positive regulation of cell migration

Disease: Camurati-engelmann Disease; Cystic Fibrosis
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 Research Articles on TGFbeta1    1. Data suggest that GSK3 (glycogen synthase kinase 3) signaling regulates TGFb1- (transforming growth factor beta 1-) induced myofibroblast differentiation by up-regulating CREB1 (cAMP responsive element binding protein 1) phosphorylation/activation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TGFbeta1 elisa kitPathways associated with TGFbeta1 elisa kit
 Reference Product  PubMed Publications
 SMAD2 elisa kit  >1285 publications with TGFbeta1 and SMAD2
 SMAD7 elisa kit  >523 publications with TGFbeta1 and SMAD7
 TGFBR3 elisa kit  >94 publications with TGFbeta1 and TGFBR3
 DCN elisa kit  >83 publications with TGFbeta1 and DCN
 TIMP1 elisa kit  >70 publications with TGFbeta1 and TIMP1
 TGFBR2 elisa kit  >67 publications with TGFbeta1 and TGFBR2
 TGFBR1 elisa kit  >59 publications with TGFbeta1 and TGFBR1
 LTBP1 elisa kit  >47 publications with TGFbeta1 and LTBP1
 FN1 elisa kit  >22 publications with TGFbeta1 and FN1
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
Diseases associated with TGFbeta1 elisa kitOrgans/Tissues associated with TGFbeta1 elisa kit
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >4868 publications with TGFbeta1 and Fibrosis
 Lung Diseases Antibodies  >1533 publications with TGFbeta1 and Lung Diseases
 Liver Cirrhosis Antibodies  >838 publications with TGFbeta1 and Liver Cirrhosis
 Pulmonary Fibrosis Antibodies  >762 publications with TGFbeta1 and Pulmonary Fibrosis
 Hypertension Antibodies  >716 publications with TGFbeta1 and Hypertension
 Proteinuria Antibodies  >494 publications with TGFbeta1 and Proteinuria
 Diabetic Nephropathies Antibodies  >465 publications with TGFbeta1 and Diabetic Nephropathies
 Hypersensitivity Antibodies  >446 publications with TGFbeta1 and Hypersensitivity
 Asthma Antibodies  >415 publications with TGFbeta1 and Asthma
 Diabetes Mellitus, Experimental Antibodies  >377 publications with TGFbeta1 and Diabetes Mellitus, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5373 publications with TGFbeta1 and Blood
 Muscle Antibodies  >3265 publications with TGFbeta1 and Muscle
 Kidney Antibodies  >2768 publications with TGFbeta1 and Kidney
 Bone Antibodies  >2348 publications with TGFbeta1 and Bone
 Lung Antibodies  >2069 publications with TGFbeta1 and Lung
 Liver Antibodies  >1960 publications with TGFbeta1 and Liver
 Connective Tissue Antibodies  >1760 publications with TGFbeta1 and Connective Tissue
 Heart Antibodies  >1241 publications with TGFbeta1 and Heart
 Skin Antibodies  >1196 publications with TGFbeta1 and Skin
 Bone Marrow Antibodies  >799 publications with TGFbeta1 and Bone Marrow
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