NP_001119578.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Y+L amino acid transporter 1
NCBI Official Synonym Full Names
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
NCBI Official Synonym Symbols
LPI; LAT3; MOP-2; Y+LAT1; y+LAT-1 [Similar Products]
NCBI Protein Information
Y+L amino acid transporter 1; Y+L amino acid transporter 1; monocyte amino acid permease 2; y(+)L-type amino acid transporter 1; solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
UniProt Protein Name
Y+L amino acid transporter 1
UniProt Synonym Protein Names
Monocyte amino acid permease 2; MOP-2; Solute carrier family 7 member 7; y(+)L-type amino acid transporter 1; Y+LAT1; y+LAT-1
UniProt Synonym Gene Names
UniProt Entry Name
YLAT1_HUMAN
NCBI Summary for SLC7A7
The protein encoded by this gene is the light subunit of a cationic amino acid transporter. This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. Defects in this gene are a cause of lysinuric protein intolerance (LPI). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]
UniProt Comments for SLC7A7
SLC7A7: Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L- arginine in monocytes. Defects in SLC7A7 are the cause of lysinuric protein intolerance (LPI). LPI is an autosomal recessive multisystem disorder found mainly in Finland and Italy. On a normal diet, LPI patients present poor feeding, vomiting, diarrhea, episodes of hyperammoniaemic coma and growth retardation. Hepatosplenomegaly, osteoporosis and a life- threatening pulmonary involvement (alveolar proteinosis) are also seen. Biochemically LPI is characterized by a defect in the plasma membrane transport of dibasic amino acids. Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
Protein type: Membrane protein, multi-pass; Transporter, SLC family; Transporter; Membrane protein, integral
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: integral to plasma membrane; basolateral plasma membrane; plasma membrane
Molecular Function: amino acid transmembrane transporter activity
Biological Process: amino acid metabolic process; transport; amino acid transport; ion transport; protein complex assembly; blood coagulation; transmembrane transport; leukocyte migration
Disease: Lysinuric Protein Intolerance
Research Articles on SLC7A7
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with SLC7A7 elisa kit
Pathways associated with SLC7A7 elisa kit
Diseases associated with SLC7A7 elisa kit
Organs/Tissues associated with SLC7A7 elisa kit
|