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beta-CTNN elisa kit :: Guinea Pig beta catenin (beta-CTNN) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS268831 beta-CTNN elisa kit
Unit / Price
48-Strip-Wells  /  $315 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,825 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,425 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

beta catenin (beta-CTNN), ELISA Kit

 Also Known As   

Guinea pig beta catenin (beta-CTNN) ELISA Kit

 Product Synonym Names    Guinea pig b catenin (b -CTNN)  ELISA Kit
 Product Gene Name   

beta-CTNN elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    615075
 3D Structure    ModBase 3D Structure for P35222
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 Species Reactivity    Guinea Pig
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of beta-CTNN elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for beta-CTNN purchase    MBS268831 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the beta catenin (beta-CTNN) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing beta-CTNN. The ELISA analytical biochemical technique of the MBS268831 kit is based on beta-CTNN antibody-beta-CTNN antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect beta-CTNN antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, beta-CTNN. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for beta-CTNN. It may not necessarily be applicable to this product.
 NCBI GI #    38520
 NCBI GeneID    1499
 NCBI Accession #    CAA79497.1 [Other Products]
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 UniProt Primary Accession #    P35222 [Other Products]
 UniProt Secondary Accession #    Q8NEW9; Q8NI94; Q9H391; A8K1L7 [Other Products]
 UniProt Related Accession #    P35222 [Other Products]
 Molecular Weight    9,501 Da
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 NCBI Official Full Name    beta catenin
 NCBI Official Synonym Full Names    catenin (cadherin-associated protein), beta 1, 88kDa
 NCBI Official Symbol    CTNNB1 [Similar Products]
 NCBI Official Synonym Symbols   
CTNNB; MRD19; armadillo
[Similar Products]
 NCBI Protein Information    catenin beta-1
 UniProt Protein Name    Catenin beta-1
 UniProt Synonym Protein Names   
Beta-catenin
 UniProt Gene Name    CTNNB1 [Similar Products]
 UniProt Synonym Gene Names    CTNNB; OK/SW-cl.35; PRO2286 [Similar Products]
 UniProt Entry Name    CTNB1_HUMAN
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 NCBI Summary for beta-CTNN    The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009]
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 UniProt Comments for beta-CTNN    CTNNB1: a regulator of cell adhesion and a key downstream effector in the Wnt signaling pathway. Implicated early embryonic development and tumorigenesis. Phosphorylated and destabilized by CK1 and GSK-3beta. Stabilized cytoplasmic beta-catenin is a hallmark of a variety of cancers. Stabilized beta-catenin translocates to the nucleus, where it acts as a transcriptional activator of T-cell factor (TCF)-regulated genes. Interacts with the PDZ domain of TAX1BP3, inhibiting its transcriptional activity. Two alternatively spliced human isoforms have been described.

Protein type: Transcription factor; Actin-binding; Oncoprotein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Cell adhesion

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: centrosome; basolateral plasma membrane; intercellular junction; fascia adherens; cytosol; beta-catenin destruction complex; transcription factor complex; cell-cell adherens junction; membrane; perinuclear region of cytoplasm; lamellipodium; cytoplasm; synapse; dendritic shaft; lateral plasma membrane; spindle pole; tight junction; focal adhesion; catenin complex; cell cortex; Z disc; nucleoplasm; adherens junction; microvillus membrane; apical part of cell; plasma membrane; nucleus; cell junction

Molecular Function: protein C-terminus binding; transcription coactivator activity; protein phosphatase binding; transcription factor binding; ionotropic glutamate receptor binding; signal transducer activity; protein binding; enzyme binding; androgen receptor binding; cadherin binding; double-stranded DNA binding; protein complex binding; estrogen receptor binding; SMAD binding; nitric-oxide synthase binding; transcription factor activity; kinase binding; nuclear hormone receptor binding; alpha-catenin binding

Biological Process: regulation of myelination; regulation of centriole-centriole cohesion; protein heterooligomerization; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; regulation of fibroblast proliferation; cell maturation; negative regulation of chondrocyte differentiation; T cell differentiation in the thymus; positive regulation of fibroblast growth factor receptor signaling pathway; osteoclast differentiation; Wnt receptor signaling pathway through beta-catenin; cell-cell adhesion; positive regulation of endothelial cell differentiation; embryonic foregut morphogenesis; regulation of cell fate specification; positive regulation of mesenchymal cell proliferation; male genitalia development; synapse organization and biogenesis; ectoderm development; cell adhesion; bone resorption; response to drug; positive regulation of neuroblast proliferation; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; regulation of smooth muscle cell proliferation; hair cell differentiation; negative regulation of protein sumoylation; patterning of blood vessels; genitalia morphogenesis; muscle cell differentiation; midgut development; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; negative regulation of transcription, DNA-dependent; oocyte development; embryonic forelimb morphogenesis; negative regulation of osteoclast differentiation; glial cell fate determination; endodermal cell fate commitment; apoptosis; cell-matrix adhesion; neuron migration; dorsal/ventral axis specification; cell fate specification; negative regulation of transcription from RNA polymerase II promoter; positive regulation of histone H3-K4 methylation; embryonic hindlimb morphogenesis; response to estradiol stimulus; negative regulation of cell proliferation; central nervous system vasculogenesis; positive regulation of MAPKKK cascade; pancreas development; positive regulation of interferon type I production; fallopian tube development; layer formation in the cerebral cortex; proximal/distal pattern formation; negative regulation of mitotic cell cycle, embryonic; cell structure disassembly during apoptosis; Wnt receptor signaling pathway; hair follicle morphogenesis; thymus development; in utero embryonic development; neural plate development; embryonic axis specification; regulation of T cell proliferation; stem cell maintenance; synaptic vesicle transport; gastrulation with mouth forming second; liver development; regulation of angiogenesis; odontogenesis of dentine-containing teeth; myoblast differentiation; negative regulation of oligodendrocyte differentiation; Schwann cell proliferation; positive regulation of osteoblast differentiation; response to cadmium ion; ureteric bud branching; response to cytokine stimulus; androgen receptor signaling pathway; positive regulation of muscle cell differentiation; embryonic heart tube development; innate immune response; epithelial to mesenchymal transition; lens morphogenesis in camera-type eye; anterior/posterior axis specification

Disease: Pilomatrixoma; Mental Retardation, Autosomal Dominant 19; Ovarian Cancer; Colorectal Cancer; Hepatocellular Carcinoma
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 Research Articles on beta-CTNN    1. Data suggest women with hepatic adenoma, now reclassified as inflammatory hepatic adenoma, exhibit mutations in CTNNB1 (beta-catenin), HNF1A (hepatic nuclear factor 1 alpha), and gp130/IL6ST (glycoprotein subunit 130, interleukin-6 receptor). [REVIEW]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with beta-CTNN elisa kitPathways associated with beta-CTNN elisa kit
 Reference Product  PubMed Publications
 APC elisa kit  >1632 publications with beta-CTNN and APC
 LEF1 elisa kit  >407 publications with beta-CTNN and LEF1
 TCF7L2 elisa kit  >334 publications with beta-CTNN and TCF7L2
 AXIN1 elisa kit  >160 publications with beta-CTNN and AXIN1
 CDH1 elisa kit  >109 publications with beta-CTNN and CDH1
 PSEN1 elisa kit  >62 publications with beta-CTNN and PSEN1
 CDH2 elisa kit  >56 publications with beta-CTNN and CDH2
 GSK3B elisa kit  >21 publications with beta-CTNN and GSK3B
 CTNNBIP1 elisa kit  >19 publications with beta-CTNN and CTNNBIP1
 CDH5 elisa kit  >1 publications with beta-CTNN and CDH5
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junctions Interactions Pathway antibodies  Adherens Junctions Interactions Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cell Adhesion Proteins Pathway antibodies  Apoptotic Cleavage Of Cell Adhesion Proteins Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
Diseases associated with beta-CTNN elisa kitOrgans/Tissues associated with beta-CTNN elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >7004 publications with beta-CTNN and Neoplasms
 Intestinal Neoplasms Antibodies  >2132 publications with beta-CTNN and Intestinal Neoplasms
 Colorectal Neoplasms Antibodies  >2065 publications with beta-CTNN and Colorectal Neoplasms
 Adenocarcinoma Antibodies  >1630 publications with beta-CTNN and Adenocarcinoma
 Colonic Neoplasms Antibodies  >1177 publications with beta-CTNN and Colonic Neoplasms
 Adenoma Antibodies  >840 publications with beta-CTNN and Adenoma
 Liver Neoplasms Antibodies  >813 publications with beta-CTNN and Liver Neoplasms
 Liver Diseases Antibodies  >789 publications with beta-CTNN and Liver Diseases
 Breast Neoplasms Antibodies  >673 publications with beta-CTNN and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >591 publications with beta-CTNN and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1310 publications with beta-CTNN and Bone
 Liver Antibodies  >1222 publications with beta-CTNN and Liver
 Embryonic Tissue Antibodies  >1088 publications with beta-CTNN and Embryonic Tissue
 Brain Antibodies  >1065 publications with beta-CTNN and Brain
 Blood Antibodies  >984 publications with beta-CTNN and Blood
 Vascular Antibodies  >867 publications with beta-CTNN and Vascular
 Intestine Antibodies  >851 publications with beta-CTNN and Intestine
 Lung Antibodies  >798 publications with beta-CTNN and Lung
 Muscle Antibodies  >786 publications with beta-CTNN and Muscle
 Kidney Antibodies  >719 publications with beta-CTNN and Kidney
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