NP_001139551.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
NCBI Official Full Name
claudin-14
NCBI Official Synonym Full Names
claudin 14
NCBI Official Synonym Symbols
NCBI Protein Information
claudin-14
UniProt Protein Name
Claudin-14
UniProt Synonym Gene Names
UniProt Entry Name
CLD14_HUMAN
NCBI Summary for CLDN14
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]
UniProt Comments for CLDN14
Claudin-14: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Defects in CLDN14 are the cause of deafness autosomal recessive type 29 (DFNB29). DFNB29 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the claudin family.
Protein type: Cell adhesion; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: tight junction; endoplasmic reticulum; plasma membrane; integral to membrane
Molecular Function: identical protein binding; structural molecule activity
Biological Process: intercellular junction assembly and maintenance; protein complex assembly; calcium-independent cell-cell adhesion
Disease: Deafness, Autosomal Recessive 29
Research Articles on CLDN14
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Products associated with CLDN14 elisa kit
Pathways associated with CLDN14 elisa kit
Diseases associated with CLDN14 elisa kit
Organs/Tissues associated with CLDN14 elisa kit
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