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IP-10 elisa kit :: Guinea Pig interferon-inducible protein 10 (IP-10) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS260193
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $300 +1 FREE 8GB USB
96-Strip-Wells  /  $475 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,825 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,425 +4 FREE 8GB USB
 
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 Product Name   

interferon-inducible protein 10 (IP-10), ELISA Kit

★Popular Item★
 Also Known As   

Guinea pig interferon-inducible protein 10 (IP-10) ELISA Kit

 Product Gene Name   

IP-10 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    176871
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 Species Reactivity    Guinea Pig
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 Specificity    No cross-reaction with other factors.
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 Samples    Guinea pig serum, plasma or cell culture supernatant and organizations in the natural and recombinant IP-10 concentration.
 Assay Type    Sandwich
 Detection Range    2000 pg/ml-31.2 pg/ml
 Sensitivity    Up to 12 pg/ml.
 Intra-assay Precision    <= 8%
 Inter-assay Precision    <= 12%
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of IP-10 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for IP-10 purchase    MBS260193 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the interferon-inducible protein 10 (IP-10) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 2000 pg/ml-31.2 pg/ml in biological research samples containing IP-10, with an estimated sensitivity of Up to 12 pg/ml. The ELISA analytical biochemical technique of the MBS260193 kit is based on IP-10 antibody-IP-10 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IP-10 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IP-10. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Guinea pig serum, plasma or cell culture supernatant and organizations in the natural and recombinant IP-10 concentration. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for IP-10 elisa kit

   Principle of the Assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is Guinea pig IP-10 monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.
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 Typical Testing Data/Standard Curve (for reference only) of IP-10 elisa kit    IP-10 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS260193. Click to request current manual
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NCBI/Uniprot data below describe general gene information for IP-10. It may not necessarily be applicable to this product.
 NCBI GI #    125527
 NCBI GeneID    5610
 NCBI Accession #    P19525.2 [Other Products]
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 UniProt Secondary Accession #    Q52M43; Q7Z6F6; Q9UIR4; A8K3P0; D6W584; E9PC80 [Other Products]
 UniProt Related Accession #    P19525 [Other Products]
 Molecular Weight    57,391 Da
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 NCBI Official Full Name    Interferon-induced, double-stranded RNA-activated protein kinase
 NCBI Official Synonym Full Names    eukaryotic translation initiation factor 2-alpha kinase 2
 NCBI Official Symbol    EIF2AK2 [Similar Products]
 NCBI Official Synonym Symbols   
PKR; PRKR; EIF2AK1; PPP1R83
[Similar Products]
 NCBI Protein Information    interferon-induced, double-stranded RNA-activated protein kinase; p68 kinase; eIF-2A protein kinase 2; P1/eIF-2A protein kinase; tyrosine-protein kinase EIF2AK2; interferon-inducible elF2alpha kinase; double stranded RNA activated protein kinase; protein phosphatase 1, regulatory subunit 83; protein kinase, interferon-inducible double stranded RNA dependent
 UniProt Protein Name    Interferon-induced, double-stranded RNA-activated protein kinase
 UniProt Synonym Protein Names   
Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2; Interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein kinase; Protein kinase RNA-activated; PKR; Tyrosine-protein kinase EIF2AK2 (EC:2.7.10.2); p68 kinase
 UniProt Gene Name    EIF2AK2 [Similar Products]
 UniProt Synonym Gene Names    PKR; PRKR; eIF-2A protein kinase 2; PKR [Similar Products]
 UniProt Entry Name    E2AK2_HUMAN
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 NCBI Summary for IP-10    The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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 UniProt Comments for IP-10    PKR: a protein kinase of the PEK family. Upon binding double-stranded RNA, it becomes autophosphorylated and activated. Phosphorylates and inhibits the alpha subunit of eIF2 alpha, which leads to an inhibition of the initiation of protein synthesis. Controls the activation of several transcription factors such as NF-kappaB, p53 and Stats. Mediates apoptosis induced by many different stimuli, such as LPS, TNF-alpha, viral infection and serum starvation.

Protein type: Protein kinase, Other; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; EC 2.7.10.2; Translation; Other group; PEK family

Chromosomal Location of Human Ortholog: 2p22-p21

Cellular Component: membrane; perinuclear region of cytoplasm; cytoplasm; ribosome; cytosol; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; double-stranded RNA binding; non-membrane spanning protein tyrosine kinase activity; protein phosphatase type 2A regulator activity; eukaryotic translation initiation factor 2alpha kinase activity; ATP binding; protein kinase activity

Biological Process: positive regulation of cytokine production; peptidyl-tyrosine phosphorylation; transcription, DNA-dependent; translation; activation of MAPKK activity; unfolded protein response; response to virus; protein amino acid autophosphorylation; viral infectious cycle; protein amino acid phosphorylation; evasion by virus of host immune response; positive regulation of stress-activated MAPK cascade; positive regulation of chemokine production; activation of NF-kappaB transcription factor; negative regulation of cell proliferation; modification by virus of host cellular process; negative regulation of viral genome replication; virus-host interaction; negative regulation of translation; innate immune response; negative regulation of osteoblast proliferation; defense response to virus; negative regulation of apoptosis
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 Research Articles on IP-10    1. Cyclophilin inhibitors reduce phosphorylation of PKR and eIF2alpha during HCV infection to allow for translation of ISG products.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IP-10 elisa kitPathways associated with IP-10 elisa kit
 Reference Product  PubMed Publications
 STAT1 elisa kit  >3 publications with IP-10 and STAT1
 STAT3 elisa kit  >2 publications with IP-10 and STAT3
 EIF2S1 elisa kit  >1 publications with IP-10 and EIF2S1
 Products by Pathway  Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Ceramide Signaling Pathway antibodies  Ceramide Signaling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
Diseases associated with IP-10 elisa kitOrgans/Tissues associated with IP-10 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >5 publications with IP-10 and Inflammation
 Brain Diseases Antibodies  >4 publications with IP-10 and Brain Diseases
 Nervous System Diseases Antibodies  >4 publications with IP-10 and Nervous System Diseases
 Liver Diseases Antibodies  >3 publications with IP-10 and Liver Diseases
 Lung Diseases Antibodies  >2 publications with IP-10 and Lung Diseases
 Disease Models, Animal Antibodies  >1 publications with IP-10 and Disease Models, Animal
 Necrosis Antibodies  >1 publications with IP-10 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with IP-10 and Blood
 Liver Antibodies  >2 publications with IP-10 and Liver
 Lung Antibodies  >2 publications with IP-10 and Lung
 Skin Antibodies  >2 publications with IP-10 and Skin
 Bone Antibodies  >1 publications with IP-10 and Bone
 Lymph Node Antibodies  >1 publications with IP-10 and Lymph Node
 Muscle Antibodies  >1 publications with IP-10 and Muscle
 Brain Antibodies  >1 publications with IP-10 and Brain
 Uterus Antibodies  >1 publications with IP-10 and Uterus
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