NP_001268516.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
77,873 Da
NCBI Official Full Name
arachidonate 5-lipoxygenase
NCBI Official Synonym Symbols
NCBI Protein Information
arachidonate 5-lipoxygenase
UniProt Protein Name
Arachidonate 5-lipoxygenase
UniProt Synonym Gene Names
UniProt Entry Name
LOX5_MESAU
UniProt Comments for ALOX-5
Function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
Catalytic activity: Arachidonate + O2 = leukotriene A4 + H2O.
Cofactor: Binds 1 iron ion per subunit
By similarity.Binds 2 calcium ions per subunit
By similarity.
Pathway: Lipid metabolism; leukotriene A4 biosynthesis.
Subunit structure: Interacts with ALOX5AP and LTC4S. Interacts with COTL1, the interaction is required for stability and efficient catalytic activity
By similarity.
Subcellular location: Cytoplasm
By similarity. Nucleus matrix
By similarity. Nucleus membrane; Peripheral membrane protein
By similarity. Note: Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-271. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association
By similarity.
Post-translational modification: Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an inhibitory effect. Phosphorylation on Ser-271 prevents export from the nucleus
By similarity.
Sequence similarities: Belongs to the lipoxygenase family.Contains 1 lipoxygenase domain.Contains 1 PLAT domain.
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