NP_001276.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
100,226 Da
NCBI Official Full Name
calcium-activated chloride channel regulator 1
NCBI Official Synonym Full Names
chloride channel accessory 1
NCBI Official Synonym Symbols
CACC; GOB5; CACC1; CLCRG1; CaCC-1; hCLCA1; hCaCC-1 [Similar Products]
NCBI Protein Information
calcium-activated chloride channel regulator 1; calcium-dependent chloride channel-1; calcium-activated chloride channel protein 1; CLCA family member 1, chloride channel regulator; calcium-activated chloride channel family member 1; chloride channel, calcium activated, family member 1
UniProt Protein Name
Calcium-activated chloride channel regulator 1
UniProt Synonym Protein Names
Calcium-activated chloride channel family member 1; hCLCA1; Calcium-activated chloride channel protein 1
UniProt Synonym Gene Names
UniProt Entry Name
CLCA1_HUMAN
NCBI Summary for CLCA1
This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. [provided by RefSeq, Jul 2008]
UniProt Comments for CLCA1
CLCA1: May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. Belongs to the CLCR family.
Protein type: Channel, chloride; Vesicle
Chromosomal Location of Human Ortholog: 1p22.3
Cellular Component: extracellular space; zymogen granule membrane; microvillus; integral to plasma membrane; plasma membrane
Molecular Function: chloride channel activity; metallopeptidase activity; metal ion binding
Biological Process: transport; calcium ion transport; chloride transport; proteolysis; transmembrane transport
Research Articles on CLCA1
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Products associated with CLCA1 elisa kit
Pathways associated with CLCA1 elisa kit
Diseases associated with CLCA1 elisa kit
Organs/Tissues associated with CLCA1 elisa kit
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