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CLC1 elisa kit :: Hamster Chloride Channel Protein 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS040214 CLC1 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Chloride Channel Protein 1 (CLC1), ELISA Kit

 Also Known As   

Hamster Chloride Channel Protein 1 ELISA Kit

 Product Gene Name   

CLC1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 7; NC_000007.13 (143013219..143049097). Location: 7q35
 OMIM    118425
 3D Structure    ModBase 3D Structure for P35523
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 Species Reactivity    Hamster
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CLC1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CLC1 purchase    MBS040214 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Chloride Channel Protein 1 (CLC1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CLC1. The ELISA analytical biochemical technique of the MBS040214 kit is based on CLC1 antibody-CLC1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CLC1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CLC1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for CLC1. It may not necessarily be applicable to this product.
 NCBI GI #    119433677
 NCBI GeneID    1180
 NCBI Accession #    NP_000074.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000083.2 [Other Products]
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 UniProt Primary Accession #    P35523 [Other Products]
 UniProt Secondary Accession #    Q2M202; A4D2H5 [Other Products]
 UniProt Related Accession #    P35523 [Other Products]
 Molecular Weight    108,626 Da
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 NCBI Official Full Name    chloride channel protein 1
 NCBI Official Synonym Full Names    chloride channel, voltage-sensitive 1
 NCBI Official Symbol    CLCN1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    chloride channel protein 1; clC-1; chloride channel 1, skeletal muscle; chloride channel protein, skeletal muscle
 UniProt Protein Name    Chloride channel protein 1
 UniProt Synonym Protein Names   
Chloride channel protein, skeletal muscle
 Protein Family    Chloride channel protein
 UniProt Gene Name    CLCN1 [Similar Products]
 UniProt Synonym Gene Names    CLC1; ClC-1 [Similar Products]
 UniProt Entry Name    CLCN1_HUMAN
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 NCBI Summary for CLC1    The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
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 UniProt Comments for CLC1    CLCN1: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. Defects in CLCN1 are the cause of Thomsen disease (THD); also known as autosomal dominant myotonia congenita (MCD). THD is characterized by skeletal muscle stiffness (delayed relaxation), due to membrane hyperexcitability. A variant form of Thomsen disease is myotonia levior that is characterized by milder symptoms, later onset and absence of muscle hypo- and hypertrophy. Defects in CLCN1 are the cause of autosomal recessive myotonia congenita (MCR); also known as Becker disease. Belongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily.

Protein type: Membrane protein, multi-pass; Channel, chloride; Membrane protein, integral; Transporter, ion channel; Transporter

Chromosomal Location of Human Ortholog: 7q35

Cellular Component: integral to plasma membrane; plasma membrane; sarcolemma

Molecular Function: chloride channel activity; voltage-gated chloride channel activity

Biological Process: muscle contraction; transport; action potential propagation; transmembrane transport

Disease: Myotonia Congenita, Autosomal Recessive; Myotonia Congenita, Autosomal Dominant
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 Research Articles on CLC1    1. Our findings predict a dramatic reduction of the muscle fibre resting chloride conductance and thus fully explain the disease-causing effects of mutations C277R and C277Y of CLC1 in myotonia congenita
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CLC1 elisa kitPathways associated with CLC1 elisa kit
 Reference Product  PubMed Publications
 SCN4A elisa kit  >23 publications with CLC1 and SCN4A
 MBNL1 elisa kit  >9 publications with CLC1 and MBNL1
 DMPK elisa kit  >7 publications with CLC1 and DMPK
 CNBP elisa kit  >4 publications with CLC1 and CNBP
 CELF1 elisa kit  >1 publications with CLC1 and CELF1
 Products by Pathway  Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
Diseases associated with CLC1 elisa kitOrgans/Tissues associated with CLC1 elisa kit
 Disease Name  Pubmed Publications
 Myotonia Congenita, Autosomal Recessive Antibodies  >82 publications with CLC1 and Myotonia Congenita, Autosomal Recessive
 Myotonia Congenita Antibodies  >82 publications with CLC1 and Myotonia Congenita
 Hypertrophy Antibodies  >16 publications with CLC1 and Hypertrophy
 Pain Antibodies  >9 publications with CLC1 and Pain
 Cardiovascular Diseases Antibodies  >3 publications with CLC1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >2 publications with CLC1 and Heart Diseases
 Kidney Diseases Antibodies  >2 publications with CLC1 and Kidney Diseases
 Nephrocalcinosis Antibodies  >1 publications with CLC1 and Nephrocalcinosis
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >113 publications with CLC1 and Muscle
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