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C4B elisa kit :: Hamster Complement Component 4B ELISA Kit

Scan QR to view Datasheet Catalog #    MBS021919 C4B elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Complement Component 4B (C4B), ELISA Kit

 Also Known As   

Hamster Complement Component 4B ELISA Kit

 Product Gene Name   

C4B elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    120620
 3D Structure    ModBase 3D Structure for P17927
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 Species Reactivity    Hamster
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of C4B elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for C4B purchase    MBS021919 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Complement Component 4B (C4B) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing C4B. The ELISA analytical biochemical technique of the MBS021919 kit is based on C4B antibody-C4B antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect C4B antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, C4B. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for C4B. It may not necessarily be applicable to this product.
 NCBI GI #    86793109
 NCBI GeneID    1378
 NCBI Accession #    NP_000642.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000651.4 [Other Products]
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 UniProt Primary Accession #    P17927 [Other Products]
 UniProt Secondary Accession #    Q16744; Q16745; Q5SR43; Q5SR45; Q9UQV2 [Other Products]
 UniProt Related Accession #    P17927 [Other Products]
 Molecular Weight    223,663 Da
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 NCBI Official Full Name    complement receptor type 1 isoform S
 NCBI Official Synonym Full Names    complement component (3b/4b) receptor 1 (Knops blood group)
 NCBI Official Symbol    CR1 [Similar Products]
 NCBI Official Synonym Symbols   
KN; C3BR; C4BR; CD35
[Similar Products]
 NCBI Protein Information    complement receptor type 1; CD35 antigen; C3b/C4b receptor; C3-binding protein; Knops blood group antigen
 UniProt Protein Name    Complement receptor type 1
 UniProt Synonym Protein Names   
C3b/C4b receptor
 Protein Family    Complement C4
 UniProt Gene Name    CR1 [Similar Products]
 UniProt Synonym Gene Names    C3BR [Similar Products]
 UniProt Entry Name    CR1_HUMAN
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 NCBI Summary for C4B    This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for C4B    CR1: Mediates cellular binding of particles and immune complexes that have activated complement. Belongs to the receptors of complement activation (RCA) family.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: cell surface; integral to plasma membrane; plasma membrane

Molecular Function: complement component C4b binding; complement component C3b receptor activity; complement component C4b receptor activity; complement component C3b binding

Biological Process: negative regulation of complement activation, alternative pathway; complement receptor mediated signaling pathway; negative regulation of complement activation, classical pathway; regulation of complement activation; innate immune response; complement activation, classical pathway

Disease: Knops Blood Group System; Malaria, Susceptibility To
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 Research Articles on C4B    1. Polymorphism of the complement receptor 1 gene correlates with the hematologic response to eculizumab in patients with paroxysmal nocturnal hemoglobinuria.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with C4B elisa kitPathways associated with C4B elisa kit
 Reference Product  PubMed Publications
 CR2 elisa kit  >550 publications with C4B and CR2
 CD46 elisa kit  >71 publications with C4B and CD46
 PTGS2 elisa kit  >5 publications with C4B and PTGS2
 IL8 elisa kit  >4 publications with C4B and IL8
 CFI elisa kit  >2 publications with C4B and CFI
 PTPN13 elisa kit  >1 publications with C4B and PTPN13
 C5AR1 elisa kit  >1 publications with C4B and C5AR1
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram
Diseases associated with C4B elisa kitOrgans/Tissues associated with C4B elisa kit
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >603 publications with C4B and Immune System Diseases
 Inflammation Antibodies  >171 publications with C4B and Inflammation
 Nervous System Diseases Antibodies  >140 publications with C4B and Nervous System Diseases
 Alzheimer Disease Antibodies  >88 publications with C4B and Alzheimer Disease
 Kidney Diseases Antibodies  >81 publications with C4B and Kidney Diseases
 Necrosis Antibodies  >70 publications with C4B and Necrosis
 Respiratory Tract Diseases Antibodies  >69 publications with C4B and Respiratory Tract Diseases
 Malaria Antibodies  >62 publications with C4B and Malaria
 Malaria, Falciparum Antibodies  >53 publications with C4B and Malaria, Falciparum
 Liver Diseases Antibodies  >47 publications with C4B and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1487 publications with C4B and Blood
 Vascular Antibodies  >86 publications with C4B and Vascular
 Lymph Node Antibodies  >58 publications with C4B and Lymph Node
 Lymph Antibodies  >41 publications with C4B and Lymph
 Intestine Antibodies  >27 publications with C4B and Intestine
 Nerve Antibodies  >26 publications with C4B and Nerve
 Connective Tissue Antibodies  >15 publications with C4B and Connective Tissue
 Uterus Antibodies  >8 publications with C4B and Uterus
 Mouth Antibodies  >4 publications with C4B and Mouth
 Placenta Antibodies  >3 publications with C4B and Placenta
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