NP_004937.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,461 Da
NCBI Official Full Name
dedicator of cytokinesis protein 2
NCBI Official Synonym Full Names
dedicator of cytokinesis 2
NCBI Official Synonym Symbols
NCBI Protein Information
dedicator of cytokinesis protein 2
UniProt Protein Name
Dedicator of cytokinesis protein 2
UniProt Synonym Gene Names
NCBI Summary for DOCK2
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016]
UniProt Comments for DOCK2
DOCK2: a hematopoietic cell-specific CDM family protein that is indispensable for lymphocyte chemotaxis. Plays a role in T cell receptor-induced activation of Rac2 and IL-2 transcription. Interacts with RAC, CRKL, and CD3-zeta. Association with ELMO1 is critical for DOCK2-mediated Rac activation. Two alternatively-spliced isoforms have been described.
Protein type: Adaptor/scaffold; GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 5q35.1
Cellular Component: cytoskeleton; cytosol; extracellular exosome; extracellular region; membrane
Molecular Function: GTPase activator activity; protein binding; Rac guanyl-nucleotide exchange factor activity; T cell receptor binding
Biological Process: actin cytoskeleton organization; alpha-beta T cell proliferation; chemotaxis; establishment of T cell polarity; formation of immunological synapse; lipid raft polarization; macropinocytosis; myeloid dendritic cell activation involved in immune response; negative thymic T cell selection; neutrophil degranulation; positive regulation of GTPase activity; positive regulation of phagocytosis; positive thymic T cell selection; regulation of defense response to virus by virus; small GTPase mediated signal transduction
Disease: Immunodeficiency 40
Research Articles on DOCK2
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Products associated with DOCK2 elisa kit
Pathways associated with DOCK2 elisa kit
Diseases associated with DOCK2 elisa kit
Organs/Tissues associated with DOCK2 elisa kit
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