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ELN elisa kit :: Hamster Elastin ELISA Kit

Scan QR to view Datasheet Catalog #    MBS005667 ELN elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Elastin (ELN), ELISA Kit

 Also Known As   

Hamster Elastin ELISA Kit

 Product Gene Name   

ELN elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 7; NC_000007.13 (73442427..73484237). Location: 7q11.23
 OMIM    123700
 3D Structure    ModBase 3D Structure for P15502
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 Species Reactivity    Hamster
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ELN elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ELN purchase    MBS005667 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Elastin (ELN) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ELN. The ELISA analytical biochemical technique of the MBS005667 kit is based on ELN antibody-ELN antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ELN antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ELN. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ELN. It may not necessarily be applicable to this product.
 NCBI GI #    525313599
 NCBI GeneID    2006
 NCBI Accession #    NP_001265868.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001278939.1 [Other Products]
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 UniProt Primary Accession #    P15502 [Other Products]
 UniProt Secondary Accession #    O15336; O15337; Q14233; Q14234; Q14235; Q14238; Q6P0L4; Q6ZWJ6; Q75MU5; Q7Z316; B3KTS6 [Other Products]
 UniProt Related Accession #    P15502 [Other Products]
 Molecular Weight    68,469 Da
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 NCBI Official Full Name    elastin isoform m
 NCBI Official Synonym Full Names    elastin
 NCBI Official Symbol    ELN [Similar Products]
 NCBI Official Synonym Symbols   
WS; WBS; SVAS
[Similar Products]
 NCBI Protein Information    elastin; tropoelastin
 UniProt Protein Name    Elastin
 UniProt Synonym Protein Names   
Tropoelastin
 Protein Family    Elastin
 UniProt Gene Name    ELN [Similar Products]
 UniProt Entry Name    ELN_HUMAN
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 NCBI Summary for ELN    This gene encodes a protein that is one of the two components of elastic fibers. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ELN    elastin: Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle. Defects in ELN are the cause of cutis laxa, autosomal dominant, type 1 (ADCL1). A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. Additional variable clinical features are gastrointestinal diverticula, hernia, and genital prolapse. Rare manifestations are pulmonary artery stenosis, aortic aneurysm, bronchiectasis, and emphysema. Defects in ELN are the cause of supravalvular aortic stenosis (SVAS). SVAS is a congenital narrowing of the ascending aorta which can occur sporadically, as an autosomal dominant condition, or as one component of Williams-Beuren syndrome. ELN is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of ELN may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. Belongs to the elastin family. 13 isoforms of the human protein are produced by alternative splicing.

Protein type: Extracellular matrix; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: proteinaceous extracellular matrix; extracellular region

Molecular Function: protein binding; extracellular matrix structural constituent

Biological Process: cell proliferation; extracellular matrix disassembly; extracellular matrix organization and biogenesis; organ morphogenesis; blood circulation; respiratory gaseous exchange

Disease: Cutis Laxa, Autosomal Dominant 1; Williams-beuren Syndrome; Supravalvular Aortic Stenosis
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 Research Articles on ELN    1. Report increased elastin/collagen III ratio in aortic wall of myocardial infarction patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ELN elisa kitDiseases associated with ELN elisa kit
 Products by Pathway  Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >86 publications with ELN and Heart Diseases
 Aortic Stenosis, Supravalvular Antibodies  >67 publications with ELN and Aortic Stenosis, Supravalvular
 Nervous System Diseases Antibodies  >60 publications with ELN and Nervous System Diseases
 Williams Syndrome Antibodies  >58 publications with ELN and Williams Syndrome
 Neoplasms Antibodies  >38 publications with ELN and Neoplasms
 Hypertension Antibodies  >17 publications with ELN and Hypertension
 Disease Models, Animal Antibodies  >16 publications with ELN and Disease Models, Animal
 Cutis Laxa Antibodies  >10 publications with ELN and Cutis Laxa
 Heart Defects, Congenital Antibodies  >10 publications with ELN and Heart Defects, Congenital
 Hypertrophy Antibodies  >8 publications with ELN and Hypertrophy
Organs/Tissues associated with ELN elisa kit
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >53 publications with ELN and Vascular
 Muscle Antibodies  >42 publications with ELN and Muscle
 Heart Antibodies  >37 publications with ELN and Heart
 Brain Antibodies  >22 publications with ELN and Brain
 Connective Tissue Antibodies  >22 publications with ELN and Connective Tissue
 Lung Antibodies  >21 publications with ELN and Lung
 Skin Antibodies  >19 publications with ELN and Skin
 Intestine Antibodies  >13 publications with ELN and Intestine
 Bone Antibodies  >13 publications with ELN and Bone
 Eye Antibodies  >9 publications with ELN and Eye
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