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GRB10 elisa kit :: Hamster Growth Factor Receptor Bound Protein 10 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS031553 GRB10 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Growth Factor Receptor Bound Protein 10 (GRB10), ELISA Kit

 Also Known As   

Hamster Growth Factor Receptor Bound Protein 10 ELISA Kit

 Product Gene Name   

GRB10 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 7; NC_000007.13 (50657760..50861159, complement). Location: 7p12.2
 OMIM    601523
 3D Structure    ModBase 3D Structure for Q13322
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 Species Reactivity    Hamster
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of GRB10 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GRB10 purchase    MBS031553 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Growth Factor Receptor Bound Protein 10 (GRB10) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GRB10. The ELISA analytical biochemical technique of the MBS031553 kit is based on GRB10 antibody-GRB10 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GRB10 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GRB10. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for GRB10. It may not necessarily be applicable to this product.
 NCBI GI #    48762697
 NCBI GeneID    2887
 NCBI Accession #    NP_001001555.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001001555.2 [Other Products]
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 UniProt Primary Accession #    Q13322 [Other Products]
 UniProt Secondary Accession #    O00427; O00701; O75222; Q92606; Q92907; Q92948; A4D258; A7VJ95; A8K0E6; D3DVM9 [Other Products]
 UniProt Related Accession #    Q13322 [Other Products]
 Molecular Weight    67,231 Da
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 NCBI Official Full Name    growth factor receptor-bound protein 10 isoform c
 NCBI Official Synonym Full Names    growth factor receptor-bound protein 10
 NCBI Official Symbol    GRB10 [Similar Products]
 NCBI Official Synonym Symbols   
RSS; IRBP; MEG1; GRB-IR; Grb-10
[Similar Products]
 NCBI Protein Information    growth factor receptor-bound protein 10; GRB10 adapter protein; GRB10 adaptor protein; maternally expressed gene 1; insulin receptor-binding protein Grb-IR
 UniProt Protein Name    Growth factor receptor-bound protein 10
 UniProt Synonym Protein Names   
GRB10 adapter protein; Insulin receptor-binding protein Grb-IR
 Protein Family    Growth factor receptor-bound protein
 UniProt Gene Name    GRB10 [Similar Products]
 UniProt Synonym Gene Names    GRBIR; KIAA0207 [Similar Products]
 UniProt Entry Name    GRB10_HUMAN
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 NCBI Summary for GRB10    The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
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 UniProt Comments for GRB10    GRB10: an adaptor protein that inhibits insulin-stimulated IRS-PI (3)K-Akt signaling pathway by disrupting the association of IRS with the insulin receptor. Also binds activated PDGFR and EGFR. Preferentially localizes to the mitochondria, modulating the anti-apoptotic activity of mitochondrial Raf-1. Can translocate to the plasma membrane and lamellipodia. Three alternatively spliced isoforms have been described.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7p12.2

Cellular Component: cytoplasm; plasma membrane; cytosol

Molecular Function: protein binding; SH3/SH2 adaptor activity; insulin receptor binding

Biological Process: negative regulation of glucose import; negative regulation of Wnt receptor signaling pathway; insulin-like growth factor receptor signaling pathway; insulin receptor signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of phosphorylation; response to insulin stimulus; negative regulation of glycogen biosynthetic process
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 Research Articles on GRB10    1. Studies indicate that insulin receptor (IR) and IGF Type 1 Receptor (IGFR) have been identified as important partners of Grb10/14 and SH2B1/B2 adaptors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GRB10 elisa kitPathways associated with GRB10 elisa kit
 Reference Product  PubMed Publications
 IGF1R elisa kit  >23 publications with GRB10 and IGF1R
 NEDD4 elisa kit  >7 publications with GRB10 and NEDD4
 RET elisa kit  >5 publications with GRB10 and RET
 AKT1 elisa kit  >5 publications with GRB10 and AKT1
 KIT elisa kit  >3 publications with GRB10 and KIT
 RAF1 elisa kit  >3 publications with GRB10 and RAF1
 GIGYF1 elisa kit  >3 publications with GRB10 and GIGYF1
 PDGFRB elisa kit  >1 publications with GRB10 and PDGFRB
 INSR elisa kit  >1 publications with GRB10 and INSR
 Products by Pathway  Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 IGF1 Pathway antibodies  IGF1 Pathway Diagram
 Insulin Pathway antibodies  Insulin Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin Receptor Signalling Cascade Pathway antibodies  Insulin Receptor Signalling Cascade Pathway Diagram
 Kit Receptor Signaling Pathway antibodies  Kit Receptor Signaling Pathway Diagram
 PDGFR-beta Signaling Pathway antibodies  PDGFR-beta Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signal Attenuation Pathway antibodies  Signal Attenuation Pathway Diagram
 Signaling By Insulin Receptor Pathway antibodies  Signaling By Insulin Receptor Pathway Diagram
Diseases associated with GRB10 elisa kitOrgans/Tissues associated with GRB10 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >24 publications with GRB10 and Neoplasms
 Brain Diseases Antibodies  >15 publications with GRB10 and Brain Diseases
 Nervous System Diseases Antibodies  >15 publications with GRB10 and Nervous System Diseases
 Disease Models, Animal Antibodies  >7 publications with GRB10 and Disease Models, Animal
 Breast Neoplasms Antibodies  >6 publications with GRB10 and Breast Neoplasms
 Weight Loss Antibodies  >5 publications with GRB10 and Weight Loss
 Cell Transformation, Neoplastic Antibodies  >3 publications with GRB10 and Cell Transformation, Neoplastic
 Kidney Diseases Antibodies  >3 publications with GRB10 and Kidney Diseases
 Adenocarcinoma Antibodies  >3 publications with GRB10 and Adenocarcinoma
 Uterine Cervical Neoplasms Antibodies  >2 publications with GRB10 and Uterine Cervical Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >29 publications with GRB10 and Brain
 Muscle Antibodies  >25 publications with GRB10 and Muscle
 Blood Antibodies  >22 publications with GRB10 and Blood
 Embryonic Tissue Antibodies  >22 publications with GRB10 and Embryonic Tissue
 Liver Antibodies  >16 publications with GRB10 and Liver
 Placenta Antibodies  >15 publications with GRB10 and Placenta
 Kidney Antibodies  >15 publications with GRB10 and Kidney
 Heart Antibodies  >9 publications with GRB10 and Heart
 Vascular Antibodies  >8 publications with GRB10 and Vascular
 Lung Antibodies  >8 publications with GRB10 and Lung
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