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GROB elisa kit :: Hamster Growth Regulated Oncogene Beta ELISA Kit

Scan QR to view Datasheet Catalog #    MBS012370 GROB elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Growth Regulated Oncogene Beta (GROB), ELISA Kit

 Also Known As   

Hamster Growth Regulated Oncogene Beta ELISA Kit

 Product Gene Name   

GROB elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    604948
 3D Structure    ModBase 3D Structure for O75293
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 Species Reactivity    Hamster
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of GROB elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GROB purchase    MBS012370 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Growth Regulated Oncogene Beta (GROB) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GROB. The ELISA analytical biochemical technique of the MBS012370 kit is based on GROB antibody-GROB antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GROB antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GROB. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for GROB. It may not necessarily be applicable to this product.
 NCBI GI #    86991436
 NCBI GeneID    4616
 NCBI Accession #    NP_056490.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_015675.3 [Other Products]
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 UniProt Primary Accession #    O75293 [Other Products]
 UniProt Secondary Accession #    O75960; Q17R46; A8KAM2 [Other Products]
 UniProt Related Accession #    O75293 [Other Products]
 Molecular Weight    17,818 Da
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 NCBI Official Full Name    growth arrest and DNA damage-inducible protein GADD45 beta
 NCBI Official Synonym Full Names    growth arrest and DNA-damage-inducible, beta
 NCBI Official Symbol    GADD45B [Similar Products]
 NCBI Official Synonym Symbols   
MYD118; GADD45BETA
[Similar Products]
 NCBI Protein Information    growth arrest and DNA damage-inducible protein GADD45 beta; negative growth regulatory protein MyD118; myeloid differentiation primary response protein MyD118
 UniProt Protein Name    Growth arrest and DNA damage-inducible protein GADD45 beta
 UniProt Synonym Protein Names   
Myeloid differentiation primary response protein MyD118; Negative growth regulatory protein MyD118
 UniProt Gene Name    GADD45B [Similar Products]
 UniProt Synonym Gene Names    MYD118 [Similar Products]
 UniProt Entry Name    GA45B_HUMAN
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 NCBI Summary for GROB    This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GROB    GADD45B: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK. Belongs to the GADD45 family.

Protein type: Apoptosis; Cell development/differentiation

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: activation of MAPKK activity; regulation of cell cycle; apoptosis; positive regulation of apoptosis; multicellular organismal development; activation of MAPKKK activity; response to stress; positive regulation of JNK cascade; negative regulation of protein kinase activity; cell differentiation
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 Research Articles on GROB    1. Gadd45B protects the liver through two entirely different processes: binding MKK7 to block damaging signal transduction or binding CAR to coactivate anabolic transcription. (Review)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GROB elisa kitPathways associated with GROB elisa kit
 Reference Product  PubMed Publications
 GADD45A elisa kit  >51 publications with GROB and GADD45A
 GADD45G elisa kit  >34 publications with GROB and GADD45G
 PCNA elisa kit  >13 publications with GROB and PCNA
 MAP2K3 elisa kit  >3 publications with GROB and MAP2K3
 IL18 elisa kit  >2 publications with GROB and IL18
 CCNB1 elisa kit  >2 publications with GROB and CCNB1
 MAP3K4 elisa kit  >2 publications with GROB and MAP3K4
 JAK2 elisa kit  >1 publications with GROB and JAK2
 MAP2K6 elisa kit  >1 publications with GROB and MAP2K6
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 DNA Damage Response Pathway antibodies  DNA Damage Response Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 P38 MAPK Signaling Pathway antibodies  P38 MAPK Signaling Pathway Diagram
Diseases associated with GROB elisa kitOrgans/Tissues associated with GROB elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >75 publications with GROB and Neoplasms
 Necrosis Antibodies  >25 publications with GROB and Necrosis
 Inflammation Antibodies  >22 publications with GROB and Inflammation
 Disease Models, Animal Antibodies  >19 publications with GROB and Disease Models, Animal
 Liver Diseases Antibodies  >18 publications with GROB and Liver Diseases
 Liver Neoplasms Antibodies  >16 publications with GROB and Liver Neoplasms
 Nervous System Diseases Antibodies  >14 publications with GROB and Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >13 publications with GROB and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >13 publications with GROB and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >10 publications with GROB and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >44 publications with GROB and Blood
 Liver Antibodies  >36 publications with GROB and Liver
 Brain Antibodies  >25 publications with GROB and Brain
 Lung Antibodies  >21 publications with GROB and Lung
 Bone Antibodies  >16 publications with GROB and Bone
 Bone Marrow Antibodies  >10 publications with GROB and Bone Marrow
 Heart Antibodies  >10 publications with GROB and Heart
 Muscle Antibodies  >9 publications with GROB and Muscle
 Prostate Antibodies  >8 publications with GROB and Prostate
 Ovary Antibodies  >6 publications with GROB and Ovary
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