NP_001006626.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,698 Da
NCBI Official Full Name
podoplanin isoform d
NCBI Official Synonym Full Names
podoplanin
NCBI Official Synonym Symbols
T1A; GP36; GP40; Gp38; OTS8; T1A-2; AGGRUS; HT1A-1; PA2.26 [Similar Products]
NCBI Protein Information
podoplanin; T1-alpha; hT1alpha-1; hT1alpha-2; PA2.26 antigen; glycoprotein 36; glycoprotein, 36-KD; lung type I cell membrane associated glycoprotein; lung type-I cell membrane-associated glycoprotein (T1A-2)
UniProt Protein Name
Podoplanin
UniProt Synonym Protein Names
Aggrus; Glycoprotein 36; Gp36; PA2.26 antigen; T1-alpha
UniProt Synonym Gene Names
UniProt Entry Name
PDPN_HUMAN
NCBI Summary for PDPN
This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for PDPN
PDPN: May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels. Belongs to the podoplanin family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p36.21
Cellular Component: ruffle; filopodium membrane; lamellipodium; microvillus membrane; integral to plasma membrane; apical plasma membrane; plasma membrane; external side of plasma membrane; filopodium
Molecular Function: folic acid transporter activity; water transporter activity; water channel activity; amino acid transmembrane transporter activity
Biological Process: nervous system development; water transport; cell morphogenesis; positive regulation of cell motility; signal transduction; prostaglandin metabolic process; folic acid transport; regulation of cell shape; cell proliferation; cell-cell adhesion; response to hyperoxia; amino acid transport; lymphangiogenesis; inflammatory response; tube morphogenesis; alveolus development; lung development; positive regulation of cell migration
Research Articles on PDPN
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Products associated with PDPN elisa kit
Diseases associated with PDPN elisa kit
Organs/Tissues associated with PDPN elisa kit
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