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PS2 elisa kit :: Hamster Presenilin 2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS011334 PS2 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Presenilin 2 (PS2), ELISA Kit

 Also Known As   

Hamster Presenilin 2 ELISA Kit

 Product Gene Name   

PS2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 1; NC_000001.10 (227058273..227083804). Location: 1q31-q42
 OMIM    600759
 3D Structure    ModBase 3D Structure for P49810
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 Species Reactivity    Hamster
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PS2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PS2 purchase    MBS011334 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Presenilin 2 (PS2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PS2. The ELISA analytical biochemical technique of the MBS011334 kit is based on PS2 antibody-PS2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PS2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PS2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for PS2. It may not necessarily be applicable to this product.
 NCBI GI #    156105681
 NCBI GeneID    5664
 NCBI Accession #    NP_036618.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_012486.2 [Other Products]
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 UniProt Primary Accession #    P49810 [Other Products]
 UniProt Secondary Accession #    Q96P32; A8K8D4; B1AP21 [Other Products]
 UniProt Related Accession #    P49810 [Other Products]
 Molecular Weight    50,140 Da
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 NCBI Official Full Name    presenilin-2 isoform 2
 NCBI Official Synonym Full Names    presenilin 2 (Alzheimer disease 4)
 NCBI Official Symbol    PSEN2 [Similar Products]
 NCBI Official Synonym Symbols   
AD4; PS2; AD3L; STM2; CMD1V
[Similar Products]
 NCBI Protein Information    presenilin-2; AD5; E5-1; PS-2; AD3LP; STM-2
 UniProt Protein Name    Presenilin-2
 UniProt Synonym Protein Names   
AD3LP; AD5; E5-1; STM-2
 Protein Family    Inorganic pyrophosphatase
 UniProt Gene Name    PSEN2 [Similar Products]
 UniProt Synonym Gene Names    AD4; PS2; PSNL2; STM2; PS-2 [Similar Products]
 UniProt Entry Name    PSN2_HUMAN
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 NCBI Summary for PS2    Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PS2    PSEN2: probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). An integral membrane protein of the Golgi and endoplasmic reticulum. Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. Two alternative splice isoforms have been identified.

Protein type: Membrane protein, integral; Cell surface; Protease; Membrane protein, multi-pass; EC 3.4.23.-

Chromosomal Location of Human Ortholog: 1q42.13

Cellular Component: Golgi apparatus; centrosome; cell surface; integral to plasma membrane; lysosomal membrane; nuclear inner membrane; cytosol; lipid raft; kinetochore; ciliary rootlet; membrane; cell soma; perinuclear region of cytoplasm; apical plasma membrane; mitochondrial inner membrane; dendritic shaft; neuromuscular junction; endoplasmic reticulum membrane; protein complex; endoplasmic reticulum; cell cortex; Z disc; Golgi membrane; growth cone; axon; plasma membrane

Molecular Function: protein binding; endopeptidase activity; aspartic-type endopeptidase activity

Biological Process: positive regulation of catalytic activity; axon guidance; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; protein maturation; regulation of synaptic plasticity; cell fate specification; positive regulation of coagulation; T cell receptor signaling pathway; T cell activation during immune response; amyloid precursor protein catabolic process; protein transport; hair follicle development; negative regulation of protein amino acid phosphorylation; beta-amyloid metabolic process; calcium ion transport; forebrain development; brain morphogenesis; ephrin receptor signaling pathway; negative regulation of protein binding; dorsoventral neural tube patterning; embryonic limb morphogenesis; cardiac muscle contraction; Notch signaling pathway; somitogenesis; membrane protein intracellular domain proteolysis; thymus development; regulation of epidermal growth factor receptor activity; membrane protein ectodomain proteolysis; Notch receptor processing; memory; endoplasmic reticulum calcium ion homeostasis; response to hypoxia; myeloid leukocyte differentiation; hemopoietic progenitor cell differentiation; protein processing; negative regulation of protein complex assembly; alveolus development; negative regulation of apoptosis

Disease: Alzheimer Disease 4; Cardiomyopathy, Dilated, 1v
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 Research Articles on PS2    1. For the Abeta40 region on chromosome 1, association of several SNPs was observed at the presenilin 2 gene (PSEN2) in 125 subjects with severe hypertension.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PS2 elisa kitPathways associated with PS2 elisa kit
 Reference Product  PubMed Publications
 APP elisa kit  >247 publications with PS2 and APP
 NOTCH1 elisa kit  >14 publications with PS2 and NOTCH1
 PSENEN elisa kit  >12 publications with PS2 and PSENEN
 APH1A elisa kit  >10 publications with PS2 and APH1A
 NCSTN elisa kit  >5 publications with PS2 and NCSTN
 UBQLN1 elisa kit  >4 publications with PS2 and UBQLN1
 NOTCH3 elisa kit  >3 publications with PS2 and NOTCH3
 SRI elisa kit  >2 publications with PS2 and SRI
 FHL2 elisa kit  >2 publications with PS2 and FHL2
 KCNIP4 elisa kit  >1 publications with PS2 and KCNIP4
 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 FBXW7 Mutants And NOTCH1 In Cancer Pathway antibodies  FBXW7 Mutants And NOTCH1 In Cancer Pathway Diagram
Diseases associated with PS2 elisa kitOrgans/Tissues associated with PS2 elisa kit
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >34 publications with PS2 and Disease Models, Animal
 Memory Disorders Antibodies  >20 publications with PS2 and Memory Disorders
 Movement Disorders Antibodies  >16 publications with PS2 and Movement Disorders
 Cognition Disorders Antibodies  >15 publications with PS2 and Cognition Disorders
 Alzheimer disease type 4 Antibodies  >15 publications with PS2 and Alzheimer disease type 4
 Carcinoma Antibodies  >14 publications with PS2 and Carcinoma
 Nerve Degeneration Antibodies  >11 publications with PS2 and Nerve Degeneration
 Inflammation Antibodies  >10 publications with PS2 and Inflammation
 Necrosis Antibodies  >9 publications with PS2 and Necrosis
 Congenital Abnormalities Antibodies  >9 publications with PS2 and Congenital Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >234 publications with PS2 and Brain
 Blood Antibodies  >33 publications with PS2 and Blood
 Kidney Antibodies  >24 publications with PS2 and Kidney
 Vascular Antibodies  >13 publications with PS2 and Vascular
 Muscle Antibodies  >11 publications with PS2 and Muscle
 Embryonic Tissue Antibodies  >10 publications with PS2 and Embryonic Tissue
 Liver Antibodies  >10 publications with PS2 and Liver
 Heart Antibodies  >8 publications with PS2 and Heart
 Eye Antibodies  >5 publications with PS2 and Eye
 Skin Antibodies  >4 publications with PS2 and Skin
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