NP_001278232.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
542,616 Da
NCBI Official Full Name
protocadherin Fat 4 isoform 1
NCBI Official Synonym Full Names
FAT atypical cadherin 4
NCBI Official Synonym Symbols
FATJ; FAT-J; CDHF14; CDHR11; HKLLS2; VMLDS2; NBLA00548 [Similar Products]
NCBI Protein Information
protocadherin Fat 4
UniProt Protein Name
Protocadherin Fat 4
UniProt Synonym Protein Names
Cadherin family member 14; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J
UniProt Synonym Gene Names
NCBI Summary for FAT4
The protein encoded by this gene is a member of the protocadherin family. This gene may play a role in regulating planar cell polarity (PCP). Studies in mice suggest that loss of PCP signaling may cause cystic kidney disease, and mutations in this gene have been associated with Van Maldergem Syndrome 2. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Mar 2014]
UniProt Comments for FAT4
FAT4: May function in the regulation of planar cell polarity. Cadherins are cell-cell interaction molecules. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q28.1
Cellular Component: apical part of cell; extracellular exosome; integral component of membrane; intracellular; plasma membrane
Molecular Function: calcium ion binding; protein binding
Biological Process: branching involved in ureteric bud morphogenesis; cerebral cortex development; condensed mesenchymal cell proliferation; fibroblast growth factor receptor signaling pathway; gut development; heart morphogenesis; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion; inner ear receptor stereocilium organization and biogenesis; neurogenesis; Notch signaling pathway; plasma membrane organization; regulation of metanephric nephron tubule epithelial cell differentiation
Disease: Hennekam Lymphangiectasia-lymphedema Syndrome 2; Van Maldergem Syndrome 2
Research Articles on FAT4
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Pathways associated with FAT4 elisa kit
Diseases associated with FAT4 elisa kit
Organs/Tissues associated with FAT4 elisa kit
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