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STAT3 elisa kit :: Hamster Signal Transducer and Activator of Transcription 3 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS018542 STAT3 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Signal Transducer and Activator of Transcription 3 (STAT3), ELISA Kit

 Also Known As   

Hamster Signal Transducer and Activator of Transcription 3 ELISA Kit

 Product Gene Name   

STAT3 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 17; NC_000017.10 (40465343..40540513, complement). Location: 17q21.31
 OMIM    102582
 3D Structure    ModBase 3D Structure for P40763
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 Species Reactivity    Hamster
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of STAT3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for STAT3 purchase    MBS018542 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Signal Transducer and Activator of Transcription 3 (STAT3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing STAT3. The ELISA analytical biochemical technique of the MBS018542 kit is based on STAT3 antibody-STAT3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect STAT3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, STAT3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for STAT3. It may not necessarily be applicable to this product.
 NCBI GI #    21618340
 NCBI GeneID    6774
 NCBI Accession #    NP_644805.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_139276.2 [Other Products]
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 UniProt Primary Accession #    P40763 [Other Products]
 UniProt Secondary Accession #    O14916; Q9BW54; A8K7B8 [Other Products]
 UniProt Related Accession #    P40763 [Other Products]
 Molecular Weight    88,068 Da
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 NCBI Official Full Name    signal transducer and activator of transcription 3 isoform 1
 NCBI Official Synonym Full Names    signal transducer and activator of transcription 3 (acute-phase response factor)
 NCBI Official Symbol    STAT3 [Similar Products]
 NCBI Official Synonym Symbols   
APRF; HIES
[Similar Products]
 NCBI Protein Information    signal transducer and activator of transcription 3; DNA-binding protein APRF; acute-phase response factor
 UniProt Protein Name    Signal transducer and activator of transcription 3
 UniProt Synonym Protein Names   
Acute-phase response factor
 Protein Family    Signal transducer and activator of transcription
 UniProt Gene Name    STAT3 [Similar Products]
 UniProt Synonym Gene Names    APRF [Similar Products]
 UniProt Entry Name    STAT3_HUMAN
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 NCBI Summary for STAT3    The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for STAT3    STAT3: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Constitutively active in a number of human tumors. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described.

Protein type: Transcription factor; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 17q21.31

Cellular Component: nucleoplasm; mitochondrial inner membrane; cytoplasm; plasma membrane; cytosol; nucleus

Molecular Function: protein dimerization activity; protein binding; ligand-dependent nuclear receptor activity; signal transducer activity; DNA binding; sequence-specific DNA binding; protein phosphatase binding; protein kinase binding; transcription factor binding; transcription factor activity; CCR5 chemokine receptor binding; glucocorticoid receptor binding

Biological Process: transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; viral reproduction; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; radial glial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; thermoregulation; glucose homeostasis; signal transduction; response to estradiol stimulus; negative regulation of cell proliferation; astrocyte differentiation; regulation of transcription, DNA-dependent; protein import into nucleus; acute-phase response; negative regulation of glycolysis; positive regulation of Notch signaling pathway; response to drug; nervous system development; intracellular receptor-mediated signaling pathway; eating behavior; cytokine and chemokine mediated signaling pathway; regulation of multicellular organism growth; JAK-STAT cascade; cellular response to hormone stimulus; regulation of transcription from RNA polymerase II promoter; cell proliferation; response to ethanol; sexual reproduction; positive regulation of transcription from RNA polymerase II promoter; eye photoreceptor cell differentiation; cell motility; phosphorylation

Disease: Hyper-ige Recurrent Infection Syndrome, Autosomal Dominant; Autoimmune Disease, Multisystem, Infantile-onset
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 Research Articles on STAT3    1. STAT3 directly bound to the STAT3 binding site on the nm23-H1 promoter and activated its expression
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with STAT3 elisa kitPathways associated with STAT3 elisa kit
 Reference Product  PubMed Publications
 JAK2 elisa kit  >1216 publications with STAT3 and JAK2
 SRC elisa kit  >693 publications with STAT3 and SRC
 JAK1 elisa kit  >532 publications with STAT3 and JAK1
 CCND1 elisa kit  >403 publications with STAT3 and CCND1
 EGFR elisa kit  >357 publications with STAT3 and EGFR
 JAK3 elisa kit  >200 publications with STAT3 and JAK3
 MTOR elisa kit  >164 publications with STAT3 and MTOR
 PIAS3 elisa kit  >71 publications with STAT3 and PIAS3
 LEP elisa kit  >11 publications with STAT3 and LEP
 EP300 elisa kit  >8 publications with STAT3 and EP300
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
Diseases associated with STAT3 elisa kitOrgans/Tissues associated with STAT3 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3376 publications with STAT3 and Neoplasms
 Inflammation Antibodies  >1355 publications with STAT3 and Inflammation
 Carcinoma Antibodies  >1221 publications with STAT3 and Carcinoma
 Necrosis Antibodies  >663 publications with STAT3 and Necrosis
 Adenocarcinoma Antibodies  >539 publications with STAT3 and Adenocarcinoma
 Liver Diseases Antibodies  >512 publications with STAT3 and Liver Diseases
 Breast Neoplasms Antibodies  >387 publications with STAT3 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >385 publications with STAT3 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >310 publications with STAT3 and Liver Neoplasms
 Lung Neoplasms Antibodies  >268 publications with STAT3 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2244 publications with STAT3 and Blood
 Liver Antibodies  >1084 publications with STAT3 and Liver
 Brain Antibodies  >886 publications with STAT3 and Brain
 Vascular Antibodies  >803 publications with STAT3 and Vascular
 Muscle Antibodies  >666 publications with STAT3 and Muscle
 Lung Antibodies  >627 publications with STAT3 and Lung
 Bone Antibodies  >614 publications with STAT3 and Bone
 Heart Antibodies  >473 publications with STAT3 and Heart
 Skin Antibodies  >408 publications with STAT3 and Skin
 Bone Marrow Antibodies  >405 publications with STAT3 and Bone Marrow
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