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SERPINC1 elisa kit :: Hamster antithrombin-III (SERPINC1) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9310995 SERPINC1 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
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 Product Name   

antithrombin-III (SERPINC1), ELISA Kit

★Popular Item★
 Also Known As   

Hamster antithrombin-III (SERPINC1) ELISA Kit

 Product Synonym Names    Hamster antithrombin-III (SERPINC1) ELISA kit; antithrombin-III (SERPINC1)
 Product Gene Name   

SERPINC1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 613118
 3D Structure    ModBase 3D Structure for P01008
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 Species Reactivity    Hamster
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Undiluted original Hamster body fluids, tissue homogenates, secretions or feces samples.
 Assay Type    Sandwich
 Detection Range    31.2 ug/ml - 1000 ug/ml.
 Sensitivity    5.0 ug/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SERPINC1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SERPINC1 purchase    MBS9310995 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the antithrombin-III (SERPINC1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 31.2 ug/ml - 1000 ug/ml in biological research samples containing SERPINC1, with an estimated sensitivity of 5.0 ug/ml. The ELISA analytical biochemical technique of the MBS9310995 kit is based on SERPINC1 antibody-SERPINC1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SERPINC1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SERPINC1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Undiluted original Hamster body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for SERPINC1 elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of SERPINC1 (hereafter termed "analyte") in undiluted original Hamster body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9310995. Click to request current manual
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NCBI/Uniprot data below describe general gene information for SERPINC1. It may not necessarily be applicable to this product.
 NCBI GI #    4502261
 NCBI GeneID    462
 NCBI Accession #    NP_000479.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000488.3 [Other Products]
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 UniProt Primary Accession #    P01008 [Other Products]
 UniProt Secondary Accession #    P78439; P78447; Q13815; Q5TC78; Q7KZ43; Q7KZ97; Q9UC78; B2R6P0 [Other Products]
 UniProt Related Accession #    P01008 [Other Products]
 Molecular Weight    52,602 Da
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 NCBI Official Full Name    antithrombin-III
 NCBI Official Synonym Full Names    serpin peptidase inhibitor, clade C (antithrombin), member 1
 NCBI Official Symbol    SERPINC1 [Similar Products]
 NCBI Official Synonym Symbols   
AT3; AT3D; ATIII; THPH7
[Similar Products]
 NCBI Protein Information    antithrombin-III; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
 UniProt Protein Name    Antithrombin-III
 UniProt Synonym Protein Names   
Serpin C1
 Protein Family    Antithrombin
 UniProt Gene Name    SERPINC1 [Similar Products]
 UniProt Synonym Gene Names    AT3; PRO0309; ATIII [Similar Products]
 UniProt Entry Name    ANT3_HUMAN
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 NCBI Summary for SERPINC1    The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]
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 UniProt Comments for SERPINC1    SERPINC1: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D). AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin- binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations. Belongs to the serpin family.

Protein type: Secreted, signal peptide; Secreted; Inhibitor

Chromosomal Location of Human Ortholog: 1q25.1

Cellular Component: extracellular space; plasma membrane; extracellular region

Molecular Function: heparin binding; serine-type endopeptidase inhibitor activity; protein binding; protease binding

Biological Process: negative regulation of inflammatory response; blood coagulation; response to nutrient

Disease: Antithrombin Iii Deficiency
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 Research Articles on SERPINC1    1. data showed heterozygous mutations of c.2534C>T (R56C), c.13398C>A (A459D) and c.2703C>G (P112R) in the AT gene caused antithrombin (AT) deficiency in 3 unrelated Japanese pedigrees; findings suggest the A459D and P112R mutants are responsible for type I AT deficiency
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with SERPINC1 elisa kitDiseases associated with SERPINC1 elisa kit
 Products by Pathway  Pathway Diagram
 Common Pathway antibodies  Common Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Glypican 1 Network Pathway antibodies  Glypican 1 Network Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Disease Name  Pubmed Publications
 Vascular Diseases Antibodies  >3811 publications with SERPINC1 and Vascular Diseases
 Thrombosis Antibodies  >3232 publications with SERPINC1 and Thrombosis
 Blood Coagulation Disorders Antibodies  >2691 publications with SERPINC1 and Blood Coagulation Disorders
 Antithrombin III Deficiency Antibodies  >1852 publications with SERPINC1 and Antithrombin III Deficiency
 Venous Thrombosis Antibodies  >1335 publications with SERPINC1 and Venous Thrombosis
 Thromboembolism Antibodies  >1083 publications with SERPINC1 and Thromboembolism
 Disseminated Intravascular Coagulation Antibodies  >890 publications with SERPINC1 and Disseminated Intravascular Coagulation
 Inflammation Antibodies  >721 publications with SERPINC1 and Inflammation
 Hemorrhage Antibodies  >617 publications with SERPINC1 and Hemorrhage
 Liver Diseases Antibodies  >515 publications with SERPINC1 and Liver Diseases
Organs/Tissues associated with SERPINC1 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >875 publications with SERPINC1 and Liver
 Kidney Antibodies  >394 publications with SERPINC1 and Kidney
 Lung Antibodies  >348 publications with SERPINC1 and Lung
 Brain Antibodies  >245 publications with SERPINC1 and Brain
 Muscle Antibodies  >139 publications with SERPINC1 and Muscle
 Connective Tissue Antibodies  >41 publications with SERPINC1 and Connective Tissue
 Spleen Antibodies  >36 publications with SERPINC1 and Spleen
 Mammary Gland Antibodies  >3 publications with SERPINC1 and Mammary Gland
 Uncharacterized Tissue Antibodies  >1 publications with SERPINC1 and Uncharacterized Tissue
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