CAA70298.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
301,367 Da
NCBI Official Full Name
atr
NCBI Official Synonym Full Names
ATR serine/threonine kinase
NCBI Protein Information
serine/threonine-protein kinase ATR; FRAP-related protein-1; MEC1, mitosis entry checkpoint 1, homolog; ataxia telangiectasia and Rad3-related protein
UniProt Protein Name
Serine/threonine-protein kinase ATR
UniProt Synonym Protein Names
Ataxia telangiectasia and Rad3-related protein; FRAP-related protein 1
UniProt Synonym Gene Names
UniProt Entry Name
ATR_HUMAN
NCBI Summary for ATR
The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008]
UniProt Comments for ATR
ATR: a ser/thr kinase of the PIKK family most closely related to ATM. Activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]Q. Phosphorylates BRCA1, Chk1, MCM2, RAD17, RPA2, SMC1 and p53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.
Protein type: Kinase, protein; Kinase, lipid; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Membrane protein, integral; EC 2.7.11.1; ATYPICAL group; PIKK family; ATR subfamily
Chromosomal Location of Human Ortholog: 3q23
Cellular Component: XY body; nucleoplasm; Golgi apparatus; PML body; chromosome
Molecular Function: protein dimerization activity; protein serine/threonine kinase activity; protein binding; DNA binding; MutLalpha complex binding; MutSalpha complex binding; ATP binding; protein kinase activity
Biological Process: response to drug; protein amino acid autophosphorylation; multicellular organismal development; DNA repair; cell cycle; double-strand break repair via homologous recombination; peptidyl-serine phosphorylation; negative regulation of DNA replication; regulation of protein binding; DNA damage checkpoint; positive regulation of DNA damage response, signal transduction by p53 class mediator; DNA replication; response to DNA damage stimulus
Disease: Seckel Syndrome 1; Cutaneous Telangiectasia And Cancer Syndrome, Familial
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Products associated with ATR elisa kit
Pathways associated with ATR elisa kit
Diseases associated with ATR elisa kit
Organs/Tissues associated with ATR elisa kit
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