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BRCA2 elisa kit :: Horse Breast Cancer Susceptibility Protein 2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS011316 BRCA2 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Breast Cancer Susceptibility Protein 2 (BRCA2), ELISA Kit

 Also Known As   

Horse Breast Cancer Susceptibility Protein 2 ELISA Kit

 Product Gene Name   

BRCA2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 13; NC_000013.10 (32889617..32973809). Location: 13q12.3
 OMIM    114480
 3D Structure    ModBase 3D Structure for P51587
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 Species Reactivity    Horse
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of BRCA2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for BRCA2 purchase    MBS011316 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Breast Cancer Susceptibility Protein 2 (BRCA2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing BRCA2. The ELISA analytical biochemical technique of the MBS011316 kit is based on BRCA2 antibody-BRCA2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect BRCA2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, BRCA2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for BRCA2. It may not necessarily be applicable to this product.
 NCBI GI #    1161384
 NCBI GeneID    675
 NCBI Accession #    AAB07223.1 [Other Products]
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 UniProt Primary Accession #    P51587 [Other Products]
 UniProt Secondary Accession #    O00183; O15008; Q13879; Q5TBJ7 [Other Products]
 UniProt Related Accession #    P51587 [Other Products]
 Molecular Weight    384,225 Da
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 NCBI Official Full Name    BRCA2
 NCBI Official Synonym Full Names    breast cancer 2, early onset
 NCBI Official Symbol    BRCA2 [Similar Products]
 NCBI Official Synonym Symbols   
FAD; FACD; FAD1; GLM3; BRCC2; FANCB; FANCD; PNCA2; FANCD1; BROVCA2
[Similar Products]
 NCBI Protein Information    breast cancer type 2 susceptibility protein; fanconi anemia group D1 protein; breast cancer 2 tumor suppressor; BRCA1/BRCA2-containing complex, subunit 2; breast and ovarian cancer susceptibility gene, early onset; truncated breast and ovarian cancer susceptibility protein 2
 UniProt Protein Name    Breast cancer type 2 susceptibility protein
 UniProt Synonym Protein Names   
Fanconi anemia group D1 protein
 Protein Family    Breast cancer type 2 susceptibility protein
 UniProt Gene Name    BRCA2 [Similar Products]
 UniProt Synonym Gene Names    FACD; FANCD1 [Similar Products]
 UniProt Entry Name    BRCA2_HUMAN
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 NCBI Summary for BRCA2    Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]
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 UniProt Comments for BRCA2    BRCA2: involved in double-strand break repair and/or homologous recombination. May participate in S phase checkpoint activation. Interacts with RAD51 and DSS1. Interacts with ubiquitinated FANCD2. Interacts with PALB2, enables the recombinational repair and checkpoint functions. Interacts with WDR16. Defects in BRCA2 are a cause of genetic susceptibility to breast cancer and may underlie susceptibility to uveal melanoma.

Protein type: DNA repair, damage; Tumor suppressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: nucleoplasm; centrosome; protein complex; cytoplasm; BRCA2-MAGE-D1 complex; nucleus; secretory granule

Molecular Function: protein binding; H4 histone acetyltransferase activity; gamma-tubulin binding; histone acetyltransferase activity; protease binding; H3 histone acetyltransferase activity; single-stranded DNA binding

Biological Process: positive regulation of transcription, DNA-dependent; cell aging; cytokinesis; positive regulation of mitotic cell cycle; DNA repair; oocyte maturation; inner cell mass cell proliferation; regulation of cytokinesis; response to UV-C; negative regulation of mammary gland epithelial cell proliferation; double-strand break repair via homologous recombination; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; male meiosis I; nucleotide-excision repair; double-strand break repair; response to gamma radiation; spermatogenesis; hemopoiesis; replication fork protection; brain development; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; centrosome duplication; female gonad development; response to X-ray

Disease: Pancreatic Cancer, Susceptibility To, 2; Breast-ovarian Cancer, Familial, Susceptibility To, 2; Medulloblastoma; Prostate Cancer; Breast Cancer; Glioma Susceptibility 3; Tracheoesophageal Fistula With Or Without Esophageal Atresia; Fanconi Anemia, Complementation Group D1; Wilms Tumor 1
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 Research Articles on BRCA2    1. data indicate that BRCA1 carriers diagnosed with MBC have worse outcomes compared to BRCA2 carriers and non-carriers. However, the differences in outcome did not reach statistical significance likely due to small sample sizes
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BRCA2 elisa kitPathways associated with BRCA2 elisa kit
 Reference Product  PubMed Publications
 BRCA1 elisa kit  >5017 publications with BRCA2 and BRCA1
 RAD51 elisa kit  >406 publications with BRCA2 and RAD51
 TP53 elisa kit  >229 publications with BRCA2 and TP53
 PALB2 elisa kit  >142 publications with BRCA2 and PALB2
 FANCD2 elisa kit  >110 publications with BRCA2 and FANCD2
 XRCC3 elisa kit  >46 publications with BRCA2 and XRCC3
 BARD1 elisa kit  >39 publications with BRCA2 and BARD1
 FANCG elisa kit  >30 publications with BRCA2 and FANCG
 SHFM1 elisa kit  >16 publications with BRCA2 and SHFM1
 HMG20B elisa kit  >7 publications with BRCA2 and HMG20B
 Products by Pathway  Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Double-Strand Break Repair Pathway antibodies  Double-Strand Break Repair Pathway Diagram
 FOXM1 Transcription Factor Network Pathway antibodies  FOXM1 Transcription Factor Network Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Homologous DNA Pairing And Strand Exchange Pathway antibodies  Homologous DNA Pairing And Strand Exchange Pathway Diagram
 Homologous Recombination Repair Pathway antibodies  Homologous Recombination Repair Pathway Diagram
 Homologous Recombination Pathway antibodies  Homologous Recombination Pathway Diagram
 Homologous Recombination Pathway antibodies  Homologous Recombination Pathway Diagram
Diseases associated with BRCA2 elisa kitOrgans/Tissues associated with BRCA2 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5128 publications with BRCA2 and Neoplasms
 Breast Neoplasms Antibodies  >4315 publications with BRCA2 and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >2397 publications with BRCA2 and Ovarian Neoplasms
 Adenocarcinoma Antibodies  >389 publications with BRCA2 and Adenocarcinoma
 Anemia Antibodies  >248 publications with BRCA2 and Anemia
 Fanconi Anemia Antibodies  >243 publications with BRCA2 and Fanconi Anemia
 Neoplasms, Experimental Antibodies  >207 publications with BRCA2 and Neoplasms, Experimental
 Pancreatic Neoplasms Antibodies  >205 publications with BRCA2 and Pancreatic Neoplasms
 Hereditary Breast and Ovarian Cancer Syndrome Antibodies  >172 publications with BRCA2 and Hereditary Breast and Ovarian Cancer Syndrome
 Prostatic Neoplasms Antibodies  >153 publications with BRCA2 and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >98 publications with BRCA2 and Lymph Node
 Lung Antibodies  >70 publications with BRCA2 and Lung
 Mammary Gland Antibodies  >65 publications with BRCA2 and Mammary Gland
 Pancreas Antibodies  >65 publications with BRCA2 and Pancreas
 Brain Antibodies  >49 publications with BRCA2 and Brain
 Bone Marrow Antibodies  >47 publications with BRCA2 and Bone Marrow
 Liver Antibodies  >40 publications with BRCA2 and Liver
 Vascular Antibodies  >28 publications with BRCA2 and Vascular
 Testis Antibodies  >24 publications with BRCA2 and Testis
 Kidney Antibodies  >23 publications with BRCA2 and Kidney
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