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CASPASE-10 elisa kit :: Horse Caspase 10 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS032733 CASPASE-10 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Caspase 10 (CASPASE-10), ELISA Kit

 Also Known As   

Horse Caspase 10 ELISA Kit

 Product Gene Name   

CASPASE-10 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 2; NC_000002.11 (202047621..202094129). Location: 2q33-q34
 OMIM    601762
 3D Structure    ModBase 3D Structure for Q92851
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 Species Reactivity    Horse
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CASPASE-10 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CASPASE-10 purchase    MBS032733 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Caspase 10 (CASPASE-10) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CASPASE-10. The ELISA analytical biochemical technique of the MBS032733 kit is based on CASPASE-10 antibody-CASPASE-10 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CASPASE-10 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CASPASE-10. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for CASPASE-10. It may not necessarily be applicable to this product.
 NCBI GI #    47078269
 NCBI GeneID    843
 NCBI Accession #    NP_116756.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_032974.4 [Other Products]
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 UniProt Primary Accession #    Q92851 [Other Products]
 UniProt Secondary Accession #    Q6KF62; Q6KF63; Q8IUP5; Q8WYQ8; Q99845; Q9Y2U6; Q9Y2U7 [Other Products]
 UniProt Related Accession #    Q92851 [Other Products]
 Molecular Weight    58,951 Da
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 NCBI Official Full Name    caspase-10 isoform 2 preproprotein
 NCBI Official Synonym Full Names    caspase 10, apoptosis-related cysteine peptidase
 NCBI Official Symbol    CASP10 [Similar Products]
 NCBI Official Synonym Symbols   
MCH4; ALPS2; FLICE2
[Similar Products]
 NCBI Protein Information    caspase-10; CASP-10; FADD-like ICE2; apoptotic protease MCH-4; ICE-like apoptotic protease 4; interleukin-1B-converting enzyme 2; caspase 10, apoptosis-related cysteine protease; FAS-associated death domain protein interleukin-1B-converting enzyme 2
 UniProt Protein Name    Caspase-10
 UniProt Synonym Protein Names   
Apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1B-converting enzyme 2; FLICE2; ICE-like apoptotic protease 4
 UniProt Gene Name    CASP10 [Similar Products]
 UniProt Synonym Gene Names    MCH4; CASP-10; FLICE2 [Similar Products]
 UniProt Entry Name    CASPA_HUMAN
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 NCBI Summary for CASPASE-10    This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
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 UniProt Comments for CASPASE-10    CASP10: Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 23/17 kDa (p23/17) (depending on the splicing events) and a 12 kDa (p12) subunit. Self-associates. Interacts with FADD and CASP8. Found in a Fas signaling complex consisting of FAS, FADD, CASP8 and CASP10. Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon. Belongs to the peptidase C14A family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.22.63; Protease

Chromosomal Location of Human Ortholog: 2q33-q34

Cellular Component: cytoplasm; plasma membrane; CD95 death-inducing signaling complex; cytosol

Molecular Function: protein binding; ubiquitin protein ligase binding; cysteine-type endopeptidase activity

Biological Process: regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; apoptosis; innate immune response; proteolysis

Disease: Lymphoma, Non-hodgkin, Familial; Gastric Cancer; Autoimmune Lymphoproliferative Syndrome, Type Iia
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 Research Articles on CASPASE-10    1. Genetic variations in CASP8 and CASP10 may act as potential predictive biomarkers for platinum-based chemotherapy toxicity in Chinese non-small cell lung cancer patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CASPASE-10 elisa kitPathways associated with CASPASE-10 elisa kit
 Reference Product  PubMed Publications
 CASP8 elisa kit  >230 publications with CASPASE-10 and CASP8
 CASP3 elisa kit  >113 publications with CASPASE-10 and CASP3
 FADD elisa kit  >90 publications with CASPASE-10 and FADD
 TNFSF10 elisa kit  >62 publications with CASPASE-10 and TNFSF10
 CFLAR elisa kit  >41 publications with CASPASE-10 and CFLAR
 TNFRSF10B elisa kit  >37 publications with CASPASE-10 and TNFRSF10B
 FASLG elisa kit  >19 publications with CASPASE-10 and FASLG
 TNFRSF10A elisa kit  >12 publications with CASPASE-10 and TNFRSF10A
 RIPK1 elisa kit  >2 publications with CASPASE-10 and RIPK1
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Death Receptor Signalling Pathway antibodies  Death Receptor Signalling Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Extrinsic Pathway For Apoptosis antibodies  Extrinsic Pathway For Apoptosis Diagram
 FAS (CD95) Signaling Pathway antibodies  FAS (CD95) Signaling Pathway Diagram
Diseases associated with CASPASE-10 elisa kitOrgans/Tissues associated with CASPASE-10 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >139 publications with CASPASE-10 and Neoplasms
 Necrosis Antibodies  >117 publications with CASPASE-10 and Necrosis
 Leukemia Antibodies  >32 publications with CASPASE-10 and Leukemia
 Breast Neoplasms Antibodies  >23 publications with CASPASE-10 and Breast Neoplasms
 Lung Diseases Antibodies  >15 publications with CASPASE-10 and Lung Diseases
 Drug Toxicity Antibodies  >12 publications with CASPASE-10 and Drug Toxicity
 Melanoma Antibodies  >12 publications with CASPASE-10 and Melanoma
 Lymphoma, Non-Hodgkin Antibodies  >10 publications with CASPASE-10 and Lymphoma, Non-Hodgkin
 Multiple Myeloma Antibodies  >9 publications with CASPASE-10 and Multiple Myeloma
 Brain Diseases Antibodies  >8 publications with CASPASE-10 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >62 publications with CASPASE-10 and Blood
 Lung Antibodies  >25 publications with CASPASE-10 and Lung
 Skin Antibodies  >13 publications with CASPASE-10 and Skin
 Prostate Antibodies  >12 publications with CASPASE-10 and Prostate
 Kidney Antibodies  >10 publications with CASPASE-10 and Kidney
 Liver Antibodies  >9 publications with CASPASE-10 and Liver
 Bone Antibodies  >8 publications with CASPASE-10 and Bone
 Brain Antibodies  >8 publications with CASPASE-10 and Brain
 Lymph Node Antibodies  >7 publications with CASPASE-10 and Lymph Node
 Stomach Antibodies  >7 publications with CASPASE-10 and Stomach
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