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FKN elisa kit :: Horse Cx3C-Chemokine/Fractalkine ELISA Kit

Scan QR to view Datasheet Catalog #    MBS029051 FKN elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cx3C-Chemokine/Fractalkine (FKN), ELISA Kit

 Also Known As   

Horse Cx3C-Chemokine/Fractalkine ELISA Kit

 Product Gene Name   

FKN elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    601470
 3D Structure    ModBase 3D Structure for P49238
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 Species Reactivity    Horse
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of FKN elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for FKN purchase    MBS029051 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cx3C-Chemokine/Fractalkine (FKN) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing FKN. The ELISA analytical biochemical technique of the MBS029051 kit is based on FKN antibody-FKN antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FKN antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FKN. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for FKN. It may not necessarily be applicable to this product.
 NCBI GI #    4503171
 NCBI GeneID    1524
 NCBI Accession #    NP_001328.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001337.3 [Other Products]
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 UniProt Primary Accession #    P49238 [Other Products]
 UniProt Secondary Accession #    A0N0N6; B2R5Z4; J3KP17 [Other Products]
 UniProt Related Accession #    P49238 [Other Products]
 Molecular Weight    40,396 Da
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 NCBI Official Full Name    CX3C chemokine receptor 1 isoform b
 NCBI Official Synonym Full Names    chemokine (C-X3-C motif) receptor 1
 NCBI Official Symbol    CX3CR1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    CX3C chemokine receptor 1; CMK-BRL1; CMK-BRL-1; C-X3-C CKR-1; fractalkine receptor; G protein-coupled receptor 13; G-protein coupled receptor 13; chemokine (C-X3-C) receptor 1; beta chemokine receptor-like 1; chemokine (C-C) receptor-like 1
 UniProt Protein Name    CX3C chemokine receptor 1
 UniProt Synonym Protein Names   
Beta chemokine receptor-like 1; CMK-BRL-1; CMK-BRL1; Fractalkine receptor; G-protein coupled receptor 13; V28
 UniProt Gene Name    CX3CR1 [Similar Products]
 UniProt Synonym Gene Names    CMKBRL1; GPR13; C-X3-C CKR-1; CX3CR1; CMK-BRL1 [Similar Products]
 UniProt Entry Name    CX3C1_HUMAN
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 NCBI Summary for FKN    Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
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 UniProt Comments for FKN    CX3CR1: Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1. Defects in CX3CR1 are a cause of susceptibility to age- related macular degeneration type 12 (ARMD12). ARMD12 is a form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, cytokine; Membrane protein, multi-pass; Motility/polarity/chemotaxis; GPCR, family 1; Cell adhesion; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: neuron projection; integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane

Molecular Function: protein binding; chemokine receptor activity; C-X3-C chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; negative regulation of angiogenesis; cerebral cortex cell migration; viral reproduction; response to wounding; cellular defense response; chemotaxis; cell adhesion; negative regulation of cell migration; macrophage chemotaxis; microglial cell activation during immune response

Disease: Macular Degeneration, Age-related, 12; Coronary Heart Disease, Susceptibility To, 1; Human Immunodeficiency Virus Type 1, Susceptibility To
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 Research Articles on FKN    1. In a microenvironment lacking CX3CR1, the liver metastasis of colon cancer cells is significantly inhibited.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FKN elisa kitPathways associated with FKN elisa kit
 Reference Product  PubMed Publications
 CX3CL1 elisa kit  >458 publications with FKN and CX3CL1
 CCL2 elisa kit  >113 publications with FKN and CCL2
 CXCL12 elisa kit  >38 publications with FKN and CXCL12
 CCL5 elisa kit  >37 publications with FKN and CCL5
 CXCL10 elisa kit  >18 publications with FKN and CXCL10
 CCL22 elisa kit  >6 publications with FKN and CCL22
 CCL17 elisa kit  >5 publications with FKN and CCL17
 CCL21 elisa kit  >4 publications with FKN and CCL21
 CCL26 elisa kit  >3 publications with FKN and CCL26
 CCL13 elisa kit  >1 publications with FKN and CCL13
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Peptide GPCRs Pathway antibodies  Peptide GPCRs Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
Diseases associated with FKN elisa kitOrgans/Tissues associated with FKN elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >304 publications with FKN and Inflammation
 Disease Models, Animal Antibodies  >152 publications with FKN and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >139 publications with FKN and Cardiovascular Diseases
 Necrosis Antibodies  >105 publications with FKN and Necrosis
 Atherosclerosis Antibodies  >91 publications with FKN and Atherosclerosis
 Neoplasms Antibodies  >81 publications with FKN and Neoplasms
 HIV Infections Antibodies  >50 publications with FKN and HIV Infections
 Kidney Diseases Antibodies  >39 publications with FKN and Kidney Diseases
 Coronary Disease Antibodies  >35 publications with FKN and Coronary Disease
 Liver Diseases Antibodies  >31 publications with FKN and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >469 publications with FKN and Blood
 Brain Antibodies  >195 publications with FKN and Brain
 Lung Antibodies  >69 publications with FKN and Lung
 Kidney Antibodies  >63 publications with FKN and Kidney
 Spinal Cord Antibodies  >54 publications with FKN and Spinal Cord
 Liver Antibodies  >45 publications with FKN and Liver
 Spleen Antibodies  >19 publications with FKN and Spleen
 Pancreas Antibodies  >12 publications with FKN and Pancreas
 Connective Tissue Antibodies  >12 publications with FKN and Connective Tissue
 Thymus Antibodies  >10 publications with FKN and Thymus
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