NP_001165988.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
69,137 Da
NCBI Official Full Name
DNA-binding protein SATB2
NCBI Official Synonym Full Names
SATB homeobox 2
NCBI Official Synonym Symbols
NCBI Protein Information
DNA-binding protein SATB2
UniProt Protein Name
DNA-binding protein SATB2
UniProt Synonym Protein Names
Special AT-rich sequence-binding protein 2
UniProt Synonym Gene Names
UniProt Entry Name
SATB2_HUMAN
NCBI Summary for SATB2
This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and mental retardation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Feb 2010]
UniProt Comments for SATB2
SATB2: Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper- layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11). Defects in SATB2 are a cause of cleft palate isolated (CPI). A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis. A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22). Belongs to the CUT homeobox family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 2q33
Cellular Component: cytoplasm; histone deacetylase complex; nuclear matrix; nucleoplasm; nucleus; transcription factor complex
Molecular Function: chromatin binding; protein binding; sequence-specific DNA binding
Biological Process: cartilage development; chromatin remodeling; commitment of a neuronal cell to a specific type of neuron in the forebrain; embryonic pattern specification; embryonic skeletal morphogenesis; negative regulation of transcription from RNA polymerase II promoter; neuron migration; osteoblast development; palate development; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent
Disease: Glass Syndrome
Research Articles on SATB2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with SATB2 elisa kit
Diseases associated with SATB2 elisa kit
Organs/Tissues associated with SATB2 elisa kit
|