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FUM elisa kit :: Horse Fumarase/Fumarate Hydratase ELISA Kit

Scan QR to view Datasheet Catalog #    MBS027018 FUM elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fumarase/Fumarate Hydratase, ELISA Kit

 Also Known As   

Horse Fumarase/Fumarate Hydratase ELISA Kit

 Product Gene Name   

FUM elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 Chromosome Location    Chromosome: 1; NC_000001.10 (241660857..241683085, complement). Location: 1q42.1
 OMIM    136850
 3D Structure    ModBase 3D Structure for P07954
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 Species Reactivity    Horse
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of FUM elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for FUM purchase    MBS027018 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Fumarase/Fumarate Hydratase, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing FUM. The ELISA analytical biochemical technique of the MBS027018 kit is based on FUM antibody-FUM antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FUM antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FUM. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for FUM. It may not necessarily be applicable to this product.
 NCBI GI #    19743875
 NCBI GeneID    2271
 NCBI Accession #    NP_000134.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000143.3 [Other Products]
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 UniProt Primary Accession #    P07954 [Other Products]
 UniProt Related Accession #    P07954 [Other Products]
 Molecular Weight    54,637 Da
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 NCBI Official Full Name    fumarate hydratase, mitochondrial
 NCBI Official Synonym Full Names    fumarate hydratase
 NCBI Official Symbol    FH [Similar Products]
 NCBI Official Synonym Symbols   
MCL; LRCC; HLRCC; MCUL1
[Similar Products]
 NCBI Protein Information    fumarate hydratase, mitochondrial; fumarase
 UniProt Protein Name    Fumarate hydratase, mitochondrial
 UniProt Gene Name    FH [Similar Products]
 UniProt Synonym Gene Names    Fumarase [Similar Products]
 UniProt Entry Name    FUMH_HUMAN
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 NCBI Summary for FUM    The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FUM    FH: a metabolic enzyme that participates in the tricarboxylic acid cycle that catalyzes the conversion of (S)-malate into fumarate + H2O. There are two substrate binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors. Fumarate accumulates in the cell when FH is inactivated. Fumarate inhibits the dioxygenases that hydroxylate the transcription factor HIF and leads to its degradation by VHL. Since HIF turns on oncogenic pathways, FH has apparent tumor suppressor activity. Defects in FH are the cause of hereditary leiomyomatosis and renal cell cancer (HLRCC), a highly metastatic form of RCC. Defects in FH are the cause of fumarase deficiency (FD) also known as fumaricaciduria. FD is characterized by progressive encephalopathy, developmental delay, hypotonia, cerebral atrophy and lactic and pyruvic acidemia. Cells derived from a patient with HLRCC exhibit compromised oxidative phosphorylation, dependence on anaerobic glycolysis, rapid glycolytic flux, and overexpression of lactate dehydrogenase A (LDHA) and GLUT1. Two human isoforms are produced by alternative initiation. The longer isoform is mitochondrial, while the shorter form, missing residues 1-43, is cytoplasmic.

Protein type: Lyase; Mitochondrial; Tumor suppressor; Carbohydrate Metabolism - citrate (TCA) cycle; EC 4.2.1.2

Chromosomal Location of Human Ortholog: 1q42.1

Cellular Component: tricarboxylic acid cycle enzyme complex; mitochondrion; mitochondrial matrix; cytoplasm

Molecular Function: fumarate hydratase activity

Biological Process: cellular metabolic process; fumarate metabolic process; homeostasis of number of cells within a tissue; tricarboxylic acid cycle

Disease: Fumarase Deficiency
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 Research Articles on FUM    1. somatic mutations in FH do not show pronounced effect in nonsyndromic uterine leiomyomas compared to that of their syndromic counterparts.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FUM elisa kitPathways associated with FUM elisa kit
 Reference Product  PubMed Publications
 SDHB elisa kit  >11 publications with FUM and SDHB
 SDHD elisa kit  >5 publications with FUM and SDHD
 SDHC elisa kit  >4 publications with FUM and SDHC
 SOD2 elisa kit  >3 publications with FUM and SOD2
 SDHA elisa kit  >2 publications with FUM and SDHA
 MDH1 elisa kit  >2 publications with FUM and MDH1
 MDH2 elisa kit  >1 publications with FUM and MDH2
 Products by Pathway  Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway antibodies  Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway Diagram
 Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway antibodies  Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway Diagram
 Citric Acid Cycle (TCA Cycle) Pathway antibodies  Citric Acid Cycle (TCA Cycle) Pathway Diagram
 Conversion Of Glucose To Acetyl CoA And Entry Into The TCA Cycle Pathway antibodies  Conversion Of Glucose To Acetyl CoA And Entry Into The TCA Cycle Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
Diseases associated with FUM elisa kitOrgans/Tissues associated with FUM elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >498 publications with FUM and Neoplasms
 Nervous System Diseases Antibodies  >325 publications with FUM and Nervous System Diseases
 Kidney Diseases Antibodies  >251 publications with FUM and Kidney Diseases
 Brain Diseases Antibodies  >203 publications with FUM and Brain Diseases
 Inflammation Antibodies  >113 publications with FUM and Inflammation
 Adenocarcinoma Antibodies  >90 publications with FUM and Adenocarcinoma
 Hyperplasia Antibodies  >81 publications with FUM and Hyperplasia
 Anemia Antibodies  >70 publications with FUM and Anemia
 Necrosis Antibodies  >68 publications with FUM and Necrosis
 Skin Neoplasms Antibodies  >64 publications with FUM and Skin Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2028 publications with FUM and Blood
 Heart Antibodies  >707 publications with FUM and Heart
 Vascular Antibodies  >435 publications with FUM and Vascular
 Liver Antibodies  >306 publications with FUM and Liver
 Bone Antibodies  >283 publications with FUM and Bone
 Kidney Antibodies  >256 publications with FUM and Kidney
 Brain Antibodies  >239 publications with FUM and Brain
 Skin Antibodies  >190 publications with FUM and Skin
 Muscle Antibodies  >170 publications with FUM and Muscle
 Lung Antibodies  >114 publications with FUM and Lung
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