NP_002052.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,727 Da
NCBI Official Full Name
glutamate--cysteine ligase regulatory subunit
NCBI Official Synonym Full Names
glutamate-cysteine ligase, modifier subunit
NCBI Official Synonym Symbols
NCBI Protein Information
glutamate--cysteine ligase regulatory subunit; GCS light chain; GSC light chain; gamma-ECS regulatory subunit; glutamate--cysteine ligase modifier subunit; glutamate-cysteine ligase regulatory protein; gamma-glutamylcysteine synthetase regulatory subunit; glutamate-cysteine ligase modifier subunit delta2 alternative splicing; glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD)
UniProt Protein Name
Glutamate--cysteine ligase regulatory subunit
UniProt Synonym Protein Names
GCS light chain; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; Glutamate--cysteine ligase modifier subunit
UniProt Synonym Gene Names
UniProt Entry Name
GSH0_HUMAN
NCBI Summary for GBM
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. [provided by RefSeq, Jul 2008]
UniProt Comments for GBM
GCLM: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. [provided by RefSeq, Jul 2008]
Protein type: Other Amino Acids Metabolism - glutathione
Chromosomal Location of Human Ortholog: 1p22.1
Cellular Component: glutamate-cysteine ligase complex; cytosol
Molecular Function: protein heterodimerization activity; glutamate-cysteine ligase activity; enzyme regulator activity; glutamate-cysteine ligase catalytic subunit binding
Biological Process: response to drug; glutamate metabolic process; response to nitrosative stress; cysteine metabolic process; apoptotic mitochondrial changes; sulfur amino acid metabolic process; xenobiotic metabolic process; glutathione biosynthetic process; negative regulation of neuron apoptosis; response to oxidative stress; regulation of mitochondrial depolarization; regulation of blood vessel size; positive regulation of glutamate-cysteine ligase activity
Disease: Myocardial Infarction, Susceptibility To
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Products associated with GBM elisa kit
Pathways associated with GBM elisa kit
Diseases associated with GBM elisa kit
Organs/Tissues associated with GBM elisa kit
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